ACIN1

ACIN1
Identifikatori
Aliasi	ACIN1
Vanjski ID-jevi	OMIM: 604562 MGI: 1891824 HomoloGene: 22853 GeneCards: ACIN1
Lokacija gena (čovjek)
Hrom.	Hromosom 14 (čovjek)
Kraj	23,095,614 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	54,686,931 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• ATPase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje enzima; • nucleic acid binding; • vezivanje sa RNK;
Ćelijska komponenta	• nuclear speck; • ćelijska membrana; • exon-exon junction complex; • nukleoplazma; • Jedarce; • ASAP complex; • jedro; • citosol;
Biološki proces	• apoptotic chromosome condensation; • mRNA processing; • negative regulation of mRNA splicing, via spliceosome; • Prerada RNK; • positive regulation of apoptotic process; • positive regulation of monocyte differentiation; • erythrocyte differentiation; • GO:0097285 apoptoza; • execution phase of apoptosis;
	Izvori:Amigo / QuickGO
Ortolozi
	22985
	56215
	ENSG00000100813
	ENSMUSG00000022185
	Q9UKV3
	Q9JIX8
NM_001164814; NM_001164815; NM_001164816; NM_001164817; NM_014977;
	NM_001386863
NM_001085472; NM_001085473; NM_001242605; NM_001242606; NM_019567;
	NM_023190
	NP_001158286; NP_001158287; NP_001158288; NP_001158289; NP_055792
NP_001078941; NP_001078942; NP_001229534; NP_001229535; NP_062513;
	NP_075679; NP_001361699
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Apoptotski induktor hromatinskr kondenzavije u jedru je protein koji je kod ljudi kodiran genom that ACIN1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.341 aminokiselina, a molekulska težina 151.862 Da.^[8].

10	20	30	40	50
MWRRKHPRTS	GGTRGVLSGN	RGVEYGSGRG	HLGTFEGRWR	KLPKMPEAVG
TDPSTSRKMA	ELEEVTLDGK	PLQALRVTDL	KAALEQRGLA	KSGQKSALVK
RLKGALMLEN	LQKHSTPHAA	FQPNSQIGEE	MSQNSFIKQY	LEKQQELLRQ
RLEREAREAA	ELEEASAESE	DEMIHPEGVA	SLLPPDFQSS	LERPELELSR
HSPRKSSSIS	EEKGDSDDEK	PRKGERRSSR	VRQARAAKLS	EGSQPAEEEE
DQETPSRNLR	VRADRNLKTE	EEEEEEEEEE	EDDEEEEGDD	EGQKSREAPI
LKEFKEEGEE	IPRVKPEEMM	DERPKTRSQE	QEVLERGGRF	TRSQEEARKS
HLARQQQEKE	MKTTSPLEEE	EREIKSSQGL	KEKSKSPSPP	RLTEDRKKAS
LVALPEQTAS	EEETPPPLLT	KEASSPPPHP	QLHSEEEIEP	MEGPAPAVLI
QLSPPNTDAD	TRELLVSQHT	VQLVGGLSPL	SSPSDTKAES	PAEKVPEESV
LPLVQKSTLA	DYSAQKDLEP	ESDRSAQPLP	LKIEELALAK	GITEECLKQP
SLEQKEGRRA	SHTLLPSHRL	KQSADSSSSR	SSSSSSSSSR	SRSRSPDSSG
SRSHSPLRSK	QRDVAQARTH	ANPRGRPKMG	SRSTSESRSR	SRSRSRSASS
NSRKSLSPGV	SRDSSTSYTE	TKDPSSGQEV	ATPPVPQLQV	CEPKERTSTS
SSSVQARRLS	QPESAEKHVT	QRLQPERGSP	KKCEAEEAEP	PAATQPQTSE
TQTSHLPESE	RIHHTVEEKE	EVTMDTSENR	PENDVPEPPM	PIADQVSNDD
RPEGSVEDEE	KKESSLPKSF	KRKISVVSAT	KGVPAGNSDT	EGGQPGRKRR
WGASTATTQK	KPSISITTES	LKSLIPDIKP	LAGQEAVVDL	HADDSRISED
ETERNGDDGT	HDKGLKICRT	VTQVVPAEGQ	ENGQREEEEE	EKEPEAEPPV
PPQVSVEVAL	PPPAEHEVKK	VTLGDTLTRR	SISQQKSGVS	ITIDDPVRTA
QVPSPPRGKI	SNIVHISNLV	RPFTLGQLKE	LLGRTGTLVE	EAFWIDKIKS
HCFVTYSTVE	EAVATRTALH	GVKWPQSNPK	FLCADYAEQD	ELDYHRGLLV
DRPSETKTEE	QGIPRPLHPP	PPPPVQPPQH	PRAEQREQER	AVREQWAERE
REMERRERTR	SEREWDRDKV	REGPRSRSRS	RDRRRKERAK	SKEKKSEKKE
KAQEEPPAKL	LDDLFRKTKA	APCIYWLPLT	DSQIVQKEAE	RAERAKEREK
RRKEQEEEEQ	KEREKEAERE	RNRQLEREKR	REHSRERDRE	RERERERDRG
DRDRDRERDR	ERGRERDRRD	TKRHSRSRSR	STPVRDRGGR	R

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100813 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022185 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026.
^ "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".
^ "UniProt, Q9UKV3". Pristupljeno 21. 7. 2021.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma ACIN1 i stranica sa detaljima o genu ACIN1 u UCSC Genome Browseru.

Dopunska literatura[uredi | uredi izvor]

Zermati Y, Garrido C, Amsellem S, et al. (2001). "Caspase activation is required for terminal erythroid differentiation". J. Exp. Med. 193 (2): 247–54. doi:10.1084/jem.193.2.247. PMC 2193347. PMID 11208865.
Sordet O, Rébé C, Plenchette S, et al. (2003). "Specific involvement of caspases in the differentiation of monocytes into macrophages". Blood. 100 (13): 4446–53. doi:10.1182/blood-2002-06-1778. PMID 12393560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell. Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Hu Y, Yao J, Liu Z, et al. (2005). "Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation". EMBO J. 24 (20): 3543–54. doi:10.1038/sj.emboj.7600823. PMC 1276706. PMID 16177823.
Joselin AP, Schulze-Osthoff K, Schwerk C (2006). "Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis". J. Biol. Chem. 281 (18): 12475–84. doi:10.1074/jbc.M509859200. PMID 16537548.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Shu Y, Iijima T, Sun W, et al. (2007). "The ACIN1 gene is hypermethylated in early stage lung adenocarcinoma". Journal of Thoracic Oncology. 1 (2): 160–7. doi:10.1097/01243894-200602000-00010. PMID 17409846.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100813 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022185 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.

[pmid10490026-6] Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y (Sep 1999). "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation". Nature. 401 (6749): 168–73. Bibcode:1999Natur.401..168S. doi:10.1038/43678. PMID 10490026.

[entrez-7] "Entrez Gene: ACIN1 apoptotic chromatin condensation inducer 1".

[UniProt-8] "UniProt, Q9UKV3". Pristupljeno 21. 7. 2021.

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