ACSBG1
Član 1 rastegljivih acil-CoA sintetaza (ACSBG1) je enzim koji je kod ljudi kodiran genom ACSBG1.[5][6][7]
Watkins et al. (2007) odredili su da gen ACSBG1 ima 14 egzon Putem radijacijske hibridbe analize, Ishikawa et al. (1998) mapirali su ACSBG1 na hromosomu 15. Watkins et al. (2007) odredili su bližu lpkaciju ACSBG1 na minus lancu of hhromosoma15, sekvenca q23-q24.[8][9]
Protein kodiran ovim genom ima dugolančanu acil-CoA sintaznu aktivnost. Smatra se da ima središnju ulogu u mozgu vrlo dugolančanim masnim kiselinama metabolizmu i mijelinogenezi.[7] Konverziju dugih lanaca masnih kiselina u dugolančane acil-CoA, kod miševa katalizira ACSBG1.[10]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 724 aminokiseline, a molekulska težina 81.290 Da.[11].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPRNSGAGYG | CPHGDPSMLD | SRETPQESRQ | DMIVRTTQEK | LKTSSLTDRQ | ||||
| PLSKESLNHA | LELSVPEKVN | NAQWDAPEEA | LWTTRADGRV | RLRIDPSCPQ | ||||
| LPYTVHRMFY | EALDKYGDLI | ALGFKRQDKW | EHISYSQYYL | LARRAAKGFL | ||||
| KLGLKQAHSV | AILGFNSPEW | FFSAVGTVFA | GGIVTGIYTT | SSPEACQYIA | ||||
| YDCCANVIMV | DTQKQLEKIL | KIWKQLPHLK | AVVIYKEPPP | NKMANVYTME | ||||
| EFMELGNEVP | EEALDAIIDT | QQPNQCCVLV | YTSGTTGNPK | GVMLSQDNIT | ||||
| WTARYGSQAG | DIRPAEVQQE | VVVSYLPLSH | IAAQIYDLWT | GIQWGAQVCF | ||||
| AEPDALKGSL | VNTLREVEPT | SHMGVPRVWE | KIMERIQEVA | AQSGFIRRKM | ||||
| LLWAMSVTLE | QNLTCPGSDL | KPFTTRLADY | LVLAKVRQAL | GFAKCQKNFY | ||||
| GAAPMMAETQ | HFFLGLNIRL | YAGYGLSETS | GPHFMSSPYN | YRLYSSGKLV | ||||
| PGCRVKLVNQ | DAEGIGEICL | WGRTIFMGYL | NMEDKTCEAI | DEEGWLHTGD | ||||
| AGRLDADGFL | YITGRLKELI | ITAGGENVPP | VPIEEAVKME | LPIISNAMLI | ||||
| GDQRKFLSML | LTLKCTLDPD | TSDQTDNLTE | QAMEFCQRVG | SRATTVSEII | ||||
| EKKDEAVYQA | IEEGIRRVNM | NAAARPYHIQ | KWAILERDFS | ISGGELGPTM | ||||
| KLKRLTVLEK | YKGIIDSFYQ | EQKM |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000103740 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032281 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
- ^ Steinberg SJ, Morgenthaler J, Heinzer AK, Smith KD, Watkins PA (Nov 2000). "Very long-chain acyl-CoA synthetases. Human "bubblegum" represents a new family of proteins capable of activating very long-chain fatty acids". J Biol Chem. 275 (45): 35162–9. doi:10.1074/jbc.M006403200. PMID 10954726.
- ^ a b "Entrez Gene: ACSBG1 acyl-CoA synthetase bubblegum family member 1".
- ^ Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998. PubMed: 9734811
- ^ Watkins, P. A., Maiguel, D., Jia, Z., Pevsner, J. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. J. Lipid Res. 48: 2736-2750, 2007. PubMed: 17762044
- ^ Moriya-Sato A, et al. (Dec 2000). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem Biophys Res Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
- ^ "UniProt, Q96GR2". Pristupljeno 12. 7. 2021.
Dopunska literatura[uredi | uredi izvor]
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Moriya-Sato A, Hida A, Inagawa-Ogashiwa M, et al. (2001). "Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues". Biochem. Biophys. Res. Commun. 279 (1): 62–8. doi:10.1006/bbrc.2000.3897. PMID 11112418.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Pei Z, Oey NA, Zuidervaart MM, et al. (2004). "The acyl-CoA synthetase "bubblegum" (lipidosin): further characterization and role in neuronal fatty acid beta-oxidation." J. Biol. Chem. 278 (47): 47070–8. doi:10.1074/jbc.M310075200. PMID 12975357.
- Fraisl P, Forss-Petter S, Zigman M, Berger J (2004). "Murine bubblegum orthologue is a microsomal very long-chain acyl-CoA synthetase". Biochem. J. 377 (Pt 1): 85–93. doi:10.1042/BJ20031062. PMC 1223850. PMID 14516277.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Asheuer M, Bieche I, Laurendeau I, et al. (2005). "Decreased expression of ABCD4 and BG1 genes early in the pathogenesis of X-linked adrenoleukodystrophy". Hum. Mol. Genet. 14 (10): 1293–303. doi:10.1093/hmg/ddi140. PMID 15800013.
Vanjski linkovi[uredi | uredi izvor]
- Lokacija ljudskog genoma ACSBG1 i stranica sa detaljima o genu ACSBG1 u UCSC Genome Browseru.