ACTR2

S Wikipedije, slobodne enciklopedije
ACTR2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI

Identifikatori
AliasiACTR2
Vanjski ID-jeviOMIM: 604221 MGI: 1913963 HomoloGene: 4181 GeneCards: ACTR2
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za ACTR2
Genomska lokacija za ACTR2
Bend2p14Početak65,227,788 bp[1]
Kraj65,271,253 bp[1]
Lokacija gena (miš)
Hromosom 11 (miš)
Hrom.Hromosom 11 (miš)[2]
Hromosom 11 (miš)
Genomska lokacija za ACTR2
Genomska lokacija za ACTR2
Bend11 A3.1|11 12.88 cMPočetak20,012,304 bp[2]
Kraj20,062,913 bp[2]
Ontologija gena
Molekularna funkcija nucleotide binding
actin filament binding
structural constituent of cytoskeleton
actin binding
ATP binding
cytoskeletal protein binding
Ćelijska komponenta citoplazma
citosol
projekcija ćelije
membrana
focal adhesion
arp2/3 protein complex
cell cortex
actin cytoskeleton
actin cap
Egzosom
citoskelet
extracellular region
GO:0097483, GO:0097481 postsynaptic density
lamellipodium
azurophil granule lumen
ficolin-1-rich granule lumen
podosome core
Biološki proces cytosolic transport
Fc-gamma receptor signaling pathway involved in phagocytosis
actin filament organization
ephrin receptor signaling pathway
meiotic chromosome movement towards spindle pole
meiotic cytokinesis
establishment or maintenance of cell polarity
GO:0007126 Mejoza
asymmetric cell division
Arp2/3 complex-mediated actin nucleation
spindle localization
actin cytoskeleton organization
associative learning
response to immobilization stress
cellular response to trichostatin A
neutrophil degranulation
response to ethanol
cilium assembly
positive regulation of dendritic spine morphogenesis
membrane organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_005722
NM_001005386

NM_146243
NM_001362899

RefSeq (bjelančevina)

NP_001005386
NP_005713

NP_666355
NP_001349828

Lokacija (UCSC)Chr 2: 65.23 – 65.27 MbChr 11: 20.01 – 20.06 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aktinu-srodni protein 2 jest protein koji je kod ljudi kodiran genom ACTR2 sa hromosoma 3.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 394 aminokiseline, а molekulska težina 44.761 Da.[6]

1020304050
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNI
EIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNI
DTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQG
LLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLR
GYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGR
IIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH
IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRR
KHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR

Funkcija[uredi | uredi izvor]

Specifična funkcija ACTR2 još nije utvrđena. Međutim, poznato je da je glavni sastojak ARP2/3- kompleksa. Ovaj kompleks nalazi se na površini ćelije i neophodan je za oblik ćelije i pokretljivost kroz lamelipodijski aktinski sklop i izbočenje. Za ovaj genro, pnađene su dvije varijante transkripta koje kodiraju različite izoforme.[7]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138071 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020152 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  6. ^ "UniProt, P61160" (jezik: en.). Pristupljeno 9. 11. 2021.CS1 održavanje: nepoznati jezik (link)
  7. ^ "Entrez Gene: ACTR2 ARP2 actin-related protein 2 homolog (yeast)".

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]

ACTR2 detalji ljudskog genoma u UCSC Genome Browser.