ADAM11
Nepregledano
| ADAM11 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | ADAM11 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 155120 MGI: 1098667 HomoloGene: 7614 GeneCards: ADAM11 | ||||||||||||||||||||||||
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| Vrste | Čovjek | Miš | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
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| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 17: 44.76 – 44.78 Mb | Chr 11: 102.65 – 102.67 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
| Wikipodaci | |||||||||||||||||||||||||
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Protein 11 koji sadrži domen dezintegrina i metaloproteinaze je enzim koji je kod ljudi kodiran genom ADAM11.[5][6]
Aminokiselinska sekvenca
[uredi | uredi izvor]Dužina polipeptidnog lanca je 769 aminokiselina, а molekularna težina — 83.418. |content=
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| 10 | 20 | 30 | 40 | 50 | ||||
| MRLLRRWAFA | ALLLSLLPTP | GLGTQGPAGA | LRWGGLPQLG | GPGAPEVTEP | ||||
| SRLVRESSGG | EVRKQQLDTR | VRQEPPGGPP | VHLAQVSFVI | PAFNSNFTLD | ||||
| LELNHHLLSS | QYVERHFSRE | GTTQHSTGAG | DHCYYQGKLR | GNPHSFAALS | ||||
| TCQGLHGVFS | DGNLTYIVEP | QEVAGPWGAP | QGPLPHLIYR | TPLLPDPLGC | ||||
| REPGCLFAVP | AQSAPPNRPR | LRRKRQVRRG | HPTVHSETKY | VELIVINDHQ | ||||
| LFEQMRQSVV | LTSNFAKSVV | NLADVIYKEQ | LNTRIVLVAM | ETWADGDKIQ | ||||
| VQDDLLETLA | RLMVYRREGL | PEPSDATHLF | SGRTFQSTSS | GAAYVGGICS | ||||
| LSHGGGVNEY | GNMGAMAVTL | AQTLGQNLGM | MWNKHRSSAG | DCKCPDIWLG | ||||
| CIMEDTGFYL | PRKFSRCSID | EYNQFLQEGG | GSCLFNKPLK | LLDPPECGNG | ||||
| FVEAGEECDC | GSVQECSRAG | GNCCKKCTLT | HDAMCSDGLC | CRRCKYEPRG | ||||
| VSCREAVNEC | DIAETCTGDS | SQCPPNLHKL | DGYYCDHEQG | RCYGGRCKTR | ||||
| DRQCQVLWGH | AAADRFCYEK | LNVEGTERGS | CGRKGSGWVQ | CSKQDVLCGF | ||||
| LLCVNISGAP | RLGDLVGDIS | SVTFYHQGKE | LDCRGGHVQL | ADGSDLSYVE | ||||
| DGTACGPNML | CLDHRCLPAS | AFNFSTCPGS | GERRICSHHG | VCSNEGKCIC | ||||
| QPDWTGKDCS | IHNPLPTSPP | TGETERYKGP | SGTNIIIGSI | AGAVLVAAIV | ||||
| LGGTGWGFKN | IRRGRSGGA |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira člana proteinske porodice ADAM (disintegrin i metaloproteinaza). Članovi ove porodice su membranski usidreni proteini strukturno srodni dezintegrinima zmijskog otrova, a uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj gen predstavlja kandidata za gen tumor supresora za rak dojke kod ljudi na osnovu svoje lokacije unutar minimalne regije hromosoma 17, sekvenca q21, prethodno definirane mapiranjem delecije tumora.[6]
Reference
[uredi | uredi izvor]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000073670 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020926 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Emi M, Katagiri T, Harada Y, Saito H, Inazawa J, Ito I, Kasumi F, Nakamura Y (Jan 1994). "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers". Nat Genet. 5 (2): 151–7. doi:10.1038/ng1093-151. PMID 8252040. S2CID 11770397.
- 1 2 "Entrez Gene: ADAM11 ADAM metallopeptidase domain 11".
Dopunska literatura
[uredi | uredi izvor]- Wolfsberg TG, Primakoff P, Myles DG, White JM (1995). "ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell- matrix interactions". J. Cell Biol. 131 (2): 275–8. doi:10.1083/jcb.131.2.275. PMC 2199973. PMID 7593158.
- Katagiri T, Harada Y, Emi M, Nakamura Y (1994). "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing". Cytogenet. Cell Genet. 68 (1–2): 39–44. doi:10.1159/000133884. PMID 7956356.
- Sagane K, Ohya Y, Hasegawa Y, Tanaka I (1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". Biochem. J. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2). doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
- Fu GK, Wang JT, Yang J, et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Vanjski linkovi
[uredi | uredi izvor]- The MEROPS online database for peptidases and their inhibitors: M12.976 Arhivirano 11. 11. 2005. na Wayback Machine
- Lokacija ljudskog genoma ADAM11 i stranica sa detaljima o genu ADAM11 u UCSC Genome Browseru.
