ADAM18

ADAM18
Identifikatori
Aliasi	ADAM18
Vanjski ID-jevi	MGI: 105986 HomoloGene: 74941 GeneCards: ADAM18
Lokacija gena (čovjek) Hrom. Hromosom 8 (čovjek) Bend 8p11.22 Početak 39,584,489 bp Kraj 39,730,065 bp
Lokacija gena (miš) Hrom. Hromosom 8 (miš) Bend 8|8 A2 Početak 25,092,262 bp Kraj 25,164,771 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • metalloendopeptidase activity • metallopeptidase activity Ćelijska komponenta • integral component of membrane • membrana Biološki proces • multicellular organism development • Ćelijska diferencijacija • Spermatogeneza • Proteoliza Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	8749	13524
Ensembl	ENSG00000168619 ENSG00000278548	ENSMUSG00000031552
UniProt	Q9Y3Q7	Q9R157
RefSeq (mRNK)	NM_001190956 NM_014237 NM_001320313	NM_010084
RefSeq (bjelančevina)	NP_001177885 NP_001307242 NP_055052	NP_034214
Lokacija (UCSC)	Chr 8: 39.58 – 39.73 Mb	Chr 8: 25.09 – 25.16 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Protein 18 koji sadrži domenu dezintegrina i metaloproteinaze je enzim koji je kod ljudi kodiran genom ADAM18.

Ovaj gen kodira člana porodice ADAM (domen dezintegrina i metaloproteinaze). Članovi ove porodice su proteini usidreni u membrane, strukturno srodni dezintegrinima zmijskog otrova, i uključeni su u različite biološke procese, kao što su interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Protein koji kodira ovaj gen je protein površine sperme.

Dodatna literatura

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu GZ, Lin Y, Myles DG, Primakoff P (1999). "Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization". Gene. 234 (2): 227–37. doi:10.1016/S0378-1119(99)00208-5. PMID 10395895.
• Frayne J, Jury JA, Barker HL, et al. (1998). "Macaque MDC family of proteins: sequence analysis, tissue distribution and processing in the male reproductive tract". Mol. Hum. Reprod. 4 (5): 429–37. doi:10.1093/molehr/4.5.429. PMID 9665629.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi

• The MEROPS online database for peptidases and their inhibitors: M12.957
• Lokacija ljudskog genoma ADAM18 i stranica sa detaljima o genu ADAM18 u UCSC Genome Browseru.