ADAM22

ADAM22
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3G5C
Identifikatori
Aliasi	ADAM22
Vanjski ID-jevi	OMIM: 603709 MGI: 1340046 HomoloGene: 37898 GeneCards: ADAM22
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	88,202,889 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	8,418,160 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• integrin binding; • metalloendopeptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • metallopeptidase activity;
Ćelijska komponenta	• integral component of membrane; • Akson; • ćelijska membrana; • projekcija ćelije; • membrana; • glutamatergic synapse; • integral component of postsynaptic density membrane;
Biološki proces	• Schwann cell differentiation; • adult locomotory behavior; • negative regulation of cell adhesion; • central nervous system development; • Ćelijska adhezija; • myelination in peripheral nervous system; • Proteoliza; • gliogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	53616
	11496
	ENSG00000008277
	ENSMUSG00000040537
	Q9P0K1
	Q9R1V6
NM_004194; NM_016351; NM_021721; NM_021722; NM_021723;
	NM_001324417; NM_001324418; NM_001324419; NM_001324420; NM_001324421; NM_001391975; NM_001391976; NM_001391977; NM_001391978; NM_001391979; NM_001391980; NM_001391981; NM_001391982
	NM_001007220; NM_001007221; NM_001098225; NM_001310439; NM_001310440
NP_001311346; NP_001311347; NP_001311348; NP_001311349; NP_001311350;
	NP_004185; NP_057435; NP_068367; NP_068368; NP_068369
	NP_001007221; NP_001007222; NP_001091695; NP_001297368; NP_001297369
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 22 koji sadrži domen dezintegrina i metaloproteinaze, također poznat kao ADAM22, je enzim koji je kod ljudi kodiran genom ADAM22.^[5]^[6]^[7]

Aminokiselinska sekvenca

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

style="font-family:monospace;"

10	20	30	40	50
MQAAVAVSVP	FLLLCVLGTC	PPARCGQAGD	ASLMELEKRK	ENRFVERQSI
VPLRLIYRSG	GEDESRHDAL	DTRVRGDLGG	PQLTHVDQAS	FQVDAFGTSF
ILDVVLNHDL	LSSEYIERHI	EHGGKTVEVK	GGEHCYYQGH	IRGNPDSFVA
LSTCHGLHGM	FYDGNHTYLI	EPEENDTTQE	DFHFHSVYKS	RLFEFSLDDL
PSEFQQVNIT	PSKFILKPRP	KRSKRQLRRY	PRNVEEETKY	IELMIVNDHL
MFKKHRLSVV	HTNTYAKSVV	NMADLIYKDQ	LKTRIVLVAM	ETWATDNKFA
ISENPLITLR	EFMKYRRDFI	KEKSDAVHLF	SGSQFESSRS	GAAYIGGICS
LLKGGGVNEF	GKTDLMAVTL	AQSLAHNIGI	ISDKRKLASG	ECKCEDTWSG
CIMGDTGYYL	PKKFTQCNIE	EYHDFLNSGG	GACLFNKPSK	LLDPPECGNG
FIETGEECDC	GTPAECVLEG	AECCKKCTLT	QDSQCSDGLC	CKKCKFQPMG
TVCREAVNDC	DIRETCSGNS	SQCAPNIHKM	DGYSCDGVQG	ICFGGRCKTR
DRQCKYIWGQ	KVTASDKYCY	EKLNIEGTEK	GNCGKDKDTW	IQCNKRDVLC
GYLLCTNIGN	IPRLGELDGE	ITSTLVVQQG	RTLNCSGGHV	KLEEDVDLGY
VEDGTPCGPQ	MMCLEHRCLP	VASFNFSTCL	SSKEGTICSG	NGVCSNELKC
VCNRHWIGSD	CNTYFPHNDD	AKTGITLSGN	GVAGTNIIIG	IIAGTILVLA
LILGITAWGY	KNYREQRQLP	QGDYVKKPGD	GDSFYSDIPP	GVSTNSASSS
KKRSNGLSHS	WSERIPDTKH	ISDICENGRP	RSNSWQGNLG	GNKKKIRGKR
FRPRSNSTET	LSPAKSPSSS	TGSIASSRKY	PYPMPPLPDE	DKKVNRQSAR
LWETSI

Funkcija

ADAM22 je član porodice ADAM (A Disintegrina Ai Metaloproteinaznog domena). Članovi ove porodice su proteini usidreni u membrani, strukturno srodni dezintegrinima zmijskog otrova dezintegrinima, i uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj gen je visoko eksprimiran u mozgu i može funkcionirati kao ligand integrina u mozgu. |Alternativno splajsovanje rezultira nekoliko transkriptnih varijanti.^[7]

Interakcije

Pokazano je da ADAM22 inter-raguje sa DLG4^[8]

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000008277 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040537 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (august 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
↑ Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (septembar 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
1 2 "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".
↑ Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (septembar 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.

Dodatni izvori

Harada T, Nishie A, Torigoe K, Ikezaki K, Shono T, Maehara Y, Kuwano M, Wada M (oktobar 2000). "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas". Japanese Journal of Cancer Research. 91 (10): 1001–6. doi:10.1111/j.1349-7006.2000.tb00877.x. PMC 5926265. PMID 11050470.
Zhu Pc, Sun Y, Xu R, Sang Y, Zhao J, Liu G, Cai L, Li C, Zhao S (februar 2003). "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading". Biochemical and Biophysical Research Communications. 301 (4): 991–9. Bibcode:2003BBRC..301..991Z. doi:10.1016/S0006-291X(03)00056-1. PMID 12589811.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2). doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Sagane K, Hayakawa K, Kai J, Hirohashi T, Takahashi E, Miyamoto N, Ino M, Oki T, Yamazaki K, Nagasu T (2006). "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice". BMC Neuroscience. 6. doi:10.1186/1471-2202-6-33. PMC 1142324. PMID 15876356.
Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S (juni 2005). "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3". Biochemical and Biophysical Research Communications. 331 (4): 938–46. Bibcode:2005BBRC..331..938Z. doi:10.1016/j.bbrc.2005.03.229. PMID 15882968.
D'Abaco GM, Ng K, Paradiso L, Godde NJ, Kaye A, Novak U (januar 2006). "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain". Neurosurgery. 58 (1): 179–86, discussion 179–86. doi:10.1227/01.NEU.0000192363.84287.8B. PMID 16385342. S2CID 24601244.
Gödde NJ, D'Abaco GM, Paradiso L, Novak U (august 2006). "Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members". Journal of Cell Science. 119 (Pt 16): 3296–305. doi:10.1242/jcs.03065. PMID 16868027.
Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (septembar 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.
Chabrol E, Gourfinkel-An I, Scheffer IE, Picard F, Couarch P, Berkovic SF, McMahon JM, Bajaj N, Mota-Vieira L, Mota R, Trouillard O, Depienne C, Baulac M, LeGuern E, Baulac S (august 2007). "Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy" (PDF). Epilepsy Research. 76 (1): 41–8. doi:10.1016/j.eplepsyres.2007.06.014. PMID 17681454. S2CID 28172409.^{[trajno mrtav link]}
Gödde NJ, D'Abaco GM, Paradiso L, Novak U (novembar 2007). "Differential coding potential of ADAM22 mRNAs". Gene. 403 (1–2): 80–8. doi:10.1016/j.gene.2007.07.033. PMID 17884303.

Vanjski linkovi

The MEROPS online database for peptidases and their inhibitors: M12.978^{[mrtav link]}
Lokacija ljudskog genoma ADAM22 i stranica sa detaljima o genu ADAM22 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000008277 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040537 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9693107-5] Sagane K, Ohya Y, Hasegawa Y, Tanaka I (august 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.

[pmid10524237-6] Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (septembar 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.

[entrez-7] 1 2 "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".

[pmid16990550-8] Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (septembar 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.

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p r u Proteaze: metaloendopeptidaze (EC 3.4.24)
ADAM-proteini	Alfa sekretaza ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matriksne metaloproteinaze	Kolagenaze MMP1 MMP8 Želatinaze MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Ostali	Neprilizin Prokolagenska peptidaza Termolizin Plazmatski protein A povezan s trudnoćom Kostni morfogenetski protein 1 Lizostafin Insulin razgrađujući enzim ZMPSTE24

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak