ADAM8

ADAM8
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4DD8
Identifikatori
Aliasi	ADAM8
Vanjski ID-jevi	OMIM: 602267 MGI: 107825 HomoloGene: 74384 GeneCards: ADAM8
Lokacija gena (čovjek)
Hrom.	Hromosom 10 (čovjek)
Kraj	133,276,868 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	139,572,475 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje iona metala; • protein self-association; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • metalloendopeptidase activity; • hydrolase activity; • cell adhesion molecule binding; • calcium ion binding; • serine-type endopeptidase activity; • metallopeptidase activity; • vezivanje iona cinka;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex; • membrana; • tertiary granule; • integral component of plasma membrane; • cell surface; • specific granule; • dense core granule membrane; • podosome; • phagolysosome; • alpha9-beta1 integrin-ADAM8 complex; • ćelijska membrana; • specific granule membrane; • tertiary granule membrane; • ficolin-1-rich granule membrane;
Biološki proces	• positive regulation of inflammatory response; • extracellular matrix disassembly; • Proteoliza; • positive regulation of cellular extravasation; • positive regulation of neutrophil extravasation; • positive regulation of protein processing; • regulation of cell-cell adhesion; • positive regulation of protein secretion; • inflammatory response; • cellular response to hypoxia; • positive regulation of T cell migration; • positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; • positive regulation of acute inflammatory response; • GO:0000767 cell morphogenesis; • positive regulation of thymocyte apoptotic process; • positive regulation of bone resorption; • GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of fibronectin-dependent thymocyte migration; • positive regulation of eosinophil migration; • positive regulation of NF-kappaB transcription factor activity; • leukocyte migration involved in inflammatory response; • positive regulation of membrane protein ectodomain proteolysis; • positive regulation of protein kinase B signaling; • positive regulation of T cell differentiation in thymus; • lymphocyte chemotaxis; • positive regulation of cell adhesion; • Angiogeneza; • neutrophil degranulation; • cell-cell adhesion; • positive regulation of MAP kinase activity; • positive regulation of innate immune response;
	Izvori:Amigo / QuickGO
Ortolozi
	101
	11501
	ENSG00000151651
	ENSMUSG00000025473
	P78325
	Q05910
	NM_001109; NM_001164489; NM_001164490
	NM_001291066; NM_007403
	NP_001100; NP_001157961; NP_001157962
	NP_001277995; NP_031429
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 8 koji sadrži domen dezintegrina i metaloproteinaze je enzim koji je kod ljudi kodiran genom ‘ADAM8’.^[5]^[6]

Funkcija

Ovaj gen kodira člana porodice ADAM (domen dezintegrina i metaloproteinaze). Članovi ove porodice su proteini usidreni u membrani, strukturno srodni dezintegrinima zmijskog otrova dezintegrinima, i uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Protein koji je kodiran ovim genom može biti uključen u adheziju ćelija tokom neurodegeneracija.^[6]

Također pogledajte

Klaster diferencijacije

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000151651 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025473 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (april 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.
1 2 "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

Dodatni izvori

Yamamoto S, Higuchi Y, Yoshiyama K, Shimizu E, Kataoka M, Hijiya N, Matsuura K (juni 1999). "ADAM family proteins in the immune system". Immunology Today. 20 (6): 278–84. doi:10.1016/S0167-5699(99)01464-4. PMID 10354553.
Schlomann U, Rathke-Hartlieb S, Yamamoto S, Jockusch H, Bartsch JW (novembar 2000). "Tumor necrosis factor alpha induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration". The Journal of Neuroscience. 20 (21): 7964–71. doi:10.1523/JNEUROSCI.20-21-07964.2000. PMC 6772711. PMID 11050116.
Amour A, Knight CG, English WR, Webster A, Slocombe PM, Knäuper V, Docherty AJ, Becherer JD, Blobel CP, Murphy G (juli 2002). "The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs". FEBS Letters. 524 (1–3): 154–8. Bibcode:2002FEBSL.524..154A. doi:10.1016/S0014-5793(02)03047-8. PMID 12135759. S2CID 37423323.
Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N, Nakamura Y (decembar 2004). "ADAM8 as a novel serological and histochemical marker for lung cancer". Clinical Cancer Research. 10 (24): 8363–70. doi:10.1158/1078-0432.CCR-04-1436. PMID 15623614.
Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Ernst P, Lemière C, Martin JG, Hamid Q (april 2007). "Increased expression of ADAM33 and ADAM8 with disease progression in asthma". The Journal of Allergy and Clinical Immunology. 119 (4): 863–71. doi:10.1016/j.jaci.2006.12.665. PMID 17339047.
Gómez-Gaviro M, Domínguez-Luis M, Canchado J, Calafat J, Janssen H, Lara-Pezzi E, Fourie A, Tugores A, Valenzuela-Fernández A, Mollinedo F, Sánchez-Madrid F, Díaz-González F (juni 2007). "Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding". Journal of Immunology. 178 (12): 8053–63. doi:10.4049/jimmunol.178.12.8053. PMID 17548643.
Valkovskaya N, Kayed H, Felix K, Hartmann D, Giese NA, Osinsky SP, Friess H, Kleeff J (2008). "ADAM8 expression is associated with increased invasiveness and reduced patient survival in pancreatic cancer". Journal of Cellular and Molecular Medicine. 11 (5): 1162–74. doi:10.1111/j.1582-4934.2007.00082.x. PMC 4401277. PMID 17979891.

Vanjski linkovi

The MEROPS online database for peptidases and their inhibitors: M12.208^{[mrtav link]}
ADAM8 lokacija ljudskog genoma UCSC Genome Browser.

ADAM8 detalji ljudskog genoma u UCSC Genome Browser.

PDBe-KB provides an overview of all the structure information available in the PDB for Human Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151651 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025473 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9126482-5] Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S (april 1997). "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location". Genomics. 41 (1): 56–62. doi:10.1006/geno.1997.4607. PMID 9126482.

[entrez-6] 1 2 "Entrez Gene: ADAM8 ADAM metallopeptidase domain 8".

[1]

[2]

[3]

[4]

[5]

[6]

p r u Proteini: Klasteri diferencijacije (također pogledati Lista ljudskih klastera diferencijacije)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

p r u Proteaze: metaloendopeptidaze (EC 3.4.24)
ADAM-proteini	Alfa sekretaza ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matriksne metaloproteinaze	Kolagenaze MMP1 MMP8 Želatinaze MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Ostali	Neprilizin Prokolagenska peptidaza Termolizin Plazmatski protein A povezan s trudnoćom Kostni morfogenetski protein 1 Lizostafin Insulin razgrađujući enzim ZMPSTE24

p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak