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Nedostajući protein melanoma 1 jest protein koji je kod ljudi kodiran genom AIM1 .[5] [6] [7]
Dužina polipeptidnog lanca je 1723 aminokiseline , а molekulska težina 188.676 Da .[8]
10 20 30 40 50 MEKRSSGRRS GRRRGSQKST DSPGADAELP ESAARDDAVF DDEVAPNAAS DNASAEKKVK SPRAALDGGV ASAASPESKP SPGTKGQLRG ESDRSKQPPP ASSPTKRKGR SRALEAVPAP PASGPRAPAK ESPPKRVPDP SPVTKGTAAE SGEEAARAIP RELPVKSSSL LPEIKPEHKR GPLPNHFNGR AEGGRSRELG RAAGAPGASD ADGLKPRNHF GVGRSTVTTK VTLPAKPKHV ELNLKTPKNL DSLGNEHNPF SQPVHKGNTA TKISLFENKR TNSSPRHTDI RGQRNTPASS KTFVGRAKLN LAKKAKEMEQ PEKKVMPNSP QNGVLVKETA IETKVTVSEE EILPATRGMN GDSSENQALG PQPNQDDKAD VQTDAGCLSE PVASALIPVK DHKLLEKEDS EAADSKSLVL ENVTDTAQDI PTTVDTKDLP PTAMPKPQHT FSDSQSPAES SPGPSLSLSA PAPGDVPKDT CVQSPISSFP CTDLKVSENH KGCVLPVSRQ NNEKMPLLEL GGETTPPLST ERSPEAVGSE CPSRVLVQVR SFVLPVESTQ DVSSQVIPES SEVREVQLPT CHSNEPEVVS VASCAPPQEE VLGNEHSHCT AELAAKSGPQ VIPPASEKTL PIQAQSQGSR TPLMAESSPT NSPSSGNHLA TPQRPDQTVT NGQDSPASLL NISAGSDDSV FDSSSDMEKF TEIIKQMDSA VCMPMKRKKA RMPNSPAPHF AMPPIHEDHL EKVFDPKVFT FGLGKKKESQ PEMSPALHLM QNLDTKSKLR PKRASAEQSV LFKSLHTNTN GNSEPLVMPE INDKENRDVT NGGIKRSRLE KSALFSSLLS SLPQDKIFSP SVTSVNTMTT AFSTSQNGSL SQSSVSQPTT EGAPPCGLNK EQSNLLPDNS LKVFNFNSSS TSHSSLKSPS HMEKYPQKEK TKEDLDSRSN LHLPETKFSE LSKLKNDDME KANHIESVIK SNLPNCANSD TDFMGLFKSS RYDPSISFSG MSLSDTMTLR GSVQNKLNPR PGKVVIYSEP DVSEKCIEVF SDIQDCSSWS LSPVILIKVV RGCWILYEQP NFEGHSIPLE EGELELSGLW GIEDILERHE EAESDKPVVI GSIRHVVQDY RVSHIDLFTE PEGLGILSSY FDDTEEMQGF GVMQKTCSMK VHWGTWLIYE EPGFQGVPFI LEPGEYPDLS FWDTEEAYIG SMRPLKMGGR KVEFPTDPKV VVYEKPFFEG KCVELETGMC SFVMEGGETE EATGDDHLPF TSVGSMKVLR GIWVAYEKPG FTGHQYLLEE GEYRDWKAWG GYNGELQSLR PILGDFSNAH MIMYSEKNFG SKGSSIDVLG IVANLKETGY GVKTQSINVL SGVWVAYENP DFTGEQYILD KGFYTSFEDW GGKNCKISSV QPICLDSFTG PRRRNQIHLF SEPQFQGHSQ SFEETTSQID DSFSTKSCRV SGGSWVVYDG ENFTGNQYVL EEGHYPCLSA MGCPPGATFK SLRFIDVEFS EPTIILFERE DFKGKKIELN AETVNLRSLG FNTQIRSVQV IGGIWVTYEY GSYRGRQFLL SPAEVPNWYE FSGCRQIGSL RPFVQKRIYF RLRNKATGLF MSTNGNLEDL KLLRIQVMED VGADDQIWIY QEGCIKCRIA EDCCLTIVGS LVTSGSKLGL ALDQNADSQF WSLKSDGRIY SKLKPNLVLD IKGGTQYDQN HIILNTVSKE KFTQVWEAMV LYT
^ a b c GRCh38: Ensembl release 89: ENSG00000112297 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019866 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J (Nov 1991). "Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma". Cancer Research . 51 (20): 5449–53. PMID 1680551 . ^ Rajini B, Graham C, Wistow G, Sharma Y (Apr 2003). "Stability, homodimerization, and calcium-binding properties of a single, variant betagamma-crystallin domain of the protein absent in melanoma 1 (AIM1)". Biochemistry . 42 (15): 4552–9. doi :10.1021/bi027384l . PMID 12693952 . ^ "Entrez Gene: AIM1 absent in melanoma 1" .^ "UniProt, Q9Y4K1" (jezik: engleski). Pristupljeno 6. 10. 2021 .
Ray ME, Su YA, Meltzer PS, Trent JM (1996). "Isolation and characterization of genes associated with chromosome-6 mediated tumor suppression in human malignant melanoma". Oncogene . 12 (12): 2527–33. PMID 8700511 . Ray ME, Wistow G, Su YA, et al. (1997). "AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma" . Proceedings of the National Academy of Sciences of the United States of America . 94 (7): 3229–34. doi :10.1073/pnas.94.7.3229 PMC 20351 PMID 9096375 . Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proceedings of the National Academy of Sciences of the United States of America . 97 (7): 3491–6. doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proceedings of the National Academy of Sciences of the United States of America . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6" . Nature . 425 (6960): 805–11. doi :10.1038/nature02055 PMID 14574404 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nature Genetics . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Aravind P, Rajini B, Sharma Y, Sankaranarayanan R (2006). "Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens" . Acta Crystallographica Section F . 62 (Pt 3): 282–4. doi :10.1107/S1744309106005380 . PMC 2197174 PMID 16511323 .
Lokacija ljudskog genoma AIM1 AIM1 UCSC Genome Browseru .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Beta/gamma crystallin domain-containing protein 1 (AIM1) 
