S Wikipedije, slobodne enciklopedije
Protein 2 srodan angiopoetinu , znan i kao angiopoetinoliki protein 2 je protein koji je kod ljudi kodiran genom ANGPTL2 .[5] [6]
Dužina polipeptidnog lanca je 493 aminokiseline , а molekulska težina 57 104 Da .[7]
10 20 30 40 50 MRPLCVTCWW LGLLAAMGAV AGQEDGFEGT EEGSPREFIY LNRYKRAGES QDKCTYTFIV PQQRVTGAIC VNSKEPEVLL ENRVHKQELE LLNNELLKQK RQIETLQQLV EVDGGIVSEV KLLRKESRNM NSRVTQLYMQ LLHEIIRKRD NALELSQLEN RILNQTADML QLASKYKDLE HKYQHLATLA HNQSEIIAQL EEHCQRVPSA RPVPQPPPAA PPRVYQPPTY NRIINQISTN EIQSDQNLKV LPPPLPTMPT LTSLPSSTDK PSGPWRDCLQ ALEDGHDTSS IYLVKPENTN RLMQVWCDQR HDPGGWTVIQ RRLDGSVNFF RNWETYKQGF GNIDGEYWLG LENIYWLTNQ GNYKLLVTME DWSGRKVFAE YASFRLEPES EYYKLRLGRY HGNAGDSFTW HNGKQFTTLD RDHDVYTGNC AHYQKGGWWY NACAHSNLNG VWYRGGHYRS RYQDGVYWAE FRGGSYSLKK VVMMIRPNPN TFH
Protein 2 sličan angiopoetinu održava homeostazu tkiva podstičući adaptivnu upalu i kasniju rekonstrukciju tkiva, dok višak aktivacije ANGPTL2 izazvan produženim stresom podstiče narušavanje homeostaze tkiva zbog hronične upale , podstičući razvoj metaboličkih bolesti. ANGPTL2 ima ulogu i u angiogenezi, u popravljanju tkiva, u gojaznosti , u ateroskleroznim bolestima i na kraju u karcinogenezi .[8]
Angiopoietini su članovi porodice faktor rasta vaskularnog endotela i jedini poznati faktori rasta koji su uglavnom specifični za vaskularni endotel . Angiopoietin-1 , angiopoietin-2 i angiopoietin-4 učestvuju u stvaranju krvnih sudova . ANGPTL2 protein je izlučeni glikoprotein s homologijom na angiopoetine i može djelovati na endotelne ćelije, djelovanjem autokrino ili parakrino .[6]
^ a b c GRCh38: Ensembl release 89: ENSG00000136859 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004105 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kim I, Moon SO, Koh KN, Kim H, Uhm CS, Kwak HJ, Kim NG, Koh GY (Oct 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting" . J Biol Chem . 274 (37): 26523–8. doi :10.1074/jbc.274.37.26523 PMID 10473614 . ^ a b "Entrez Gene: ANGPTL2 angiopoietin-like 2" .^ "UniProt, Q9UKU9" . Pristupljeno 5. 9. 2021 .^ Kadomatsu, Tsuyoshi; Endo, Motoyoshi; Miyata, Keishi; Oike, Yuichi (maj 2014). "Diverse roles of ANGPTL2 in physiology and pathophysiology" . Trends in Endocrinology & Metabolism . 25 (5): 245–254. doi :10.1016/j.tem.2014.03.012 PMID 24746520 .
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Zeng L, Dai J, Ying K, et al. (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart" . J. Hum. Genet . 48 (3): 159–62. doi :10.1007/s100380300025 PMID 12624729 . Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74. Bibcode :2004Natur.429..369H . doi :10.1038/nature02465 . PMC 2734081 PMID 15164053 . Sun H, Zheng JM, Chen S, et al. (2007). "Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy". Nephron Exp. Nephrol . 105 (4): e117–23. doi :10.1159/000100493 . PMID 17347581 . S2CID 30326676 .
