ARCN1

ARCN1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifikatori
Aliasi	ARCN1
Vanjski ID-jevi	OMIM: 600820 MGI: 2387591 HomoloGene: 1250 GeneCards: ARCN1
Lokacija gena (čovjek)
Hrom.	Hromosom 11 (čovjek)
Kraj	118,603,033 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	44,679,142 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa RNK;
Ćelijska komponenta	• citosol; • membrana; • Golđijeva membrana; • COPI-coated vesicle membrane; • transport vesicle; • Endoplazmatski retikulum; • COPI vesicle coat; • GO:0016023 citoplazmatska vezikula; • COPI-coated vesicle; • endoplasmic reticulum membrane; • citoplazma; • Golđijev aparat;
Biološki proces	• retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; • cerebellar Purkinje cell layer maturation; • adult locomotory behavior; • endoplasmic reticulum to Golgi vesicle-mediated transport; • Golgi vesicle transport; • protein transport; • pigmentation; • intracellular protein transport; • vesicle-mediated transport; • GO:0015915 transport; • Golgi localization;
	Izvori:Amigo / QuickGO
Ortolozi
	372
	213827
	ENSG00000095139
	ENSMUSG00000032096
	P48444
	Q5XJY5
	NM_001142281; NM_001655
	NM_145985
	NP_001135753; NP_001646
	NP_666097
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Arhain 1 is a protein koji je kod ljudi kodiran genom ARCN1. ^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 511 aminokiselina, a molekulska težina 57.210 Da.^[6]

10	20	30	40	50
MVLLAAAVCT	KAGKAIVSRQ	FVEMTRTRIE	GLLAAFPKLM	NTGKQHTFVE
TESVRYVYQP	MEKLYMVLIT	TKNSNILEDL	ETLRLFSRVI	PEYCRALEEN
EISEHCFDLI	FAFDEIVALG	YRENVNLAQI	RTFTEMDSHE	EKVFRAVRET
QEREAKAEMR	RKAKELQQAR	RDAERQGKKA	PGFGGFGSSA	VSGGSTAAMI
TETIIETDKP	KVAPAPARPS	GPSKALKLGA	KGKEVDNFVD	KLKSEGETIM
SSSMGKRTSE	ATKMHAPPIN	MESVHMKIEE	KITLTCGRDG	GLQNMELHGM
IMLRISDDKY	GRIRLHVENE	DKKGVQLQTH	PNVDKKLFTA	ESLIGLKNPE
KSFPVNSDVG	VLKWRLQTTE	ESFIPLTINC	WPSESGNGCD	VNIEYELQED
NLELNDVVIT	IPLPSGVGAP	VIGEIDGEYR	HDSRRNTLEW	CLPVIDAKNK
SGSLEFSIAG	QPNDFFPVQV	SFVSKKNYCN	IQVTKVTQVD	GNSPVRFSTE
TTFLVDKYEI	L

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

Funkcija

Ovaj gen nalazi se u regiji koja uključuje gen za leukemiju mjješovite loze i gene integracije virusa 1 šperona virusa leukemije, gdje se javlja višestostruka bolest usljed hromosomskih translokacija. To je unutarćelijski protein. Arhainske sekvence su među eukariotima dobro konzervirane i ovaj protein može imati temeljnu ulogu u biologiji eukariotskih ćelija. Ima sličnosti sa proteinima toplotnog šoka i proteinima povezanim s klatrinom, a može biti uključen u strukturu vezikula ili vezikulski promet

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000095139 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032096 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Archain 1". Pristupljeno 22. 6. 2016.
↑ "UniProt, P48444". Pristupljeno 16. 8. 2021.

Dopunska literatura

Deng K, Gao F, Zheng P, Gong W, Sun Z (2012). "Crystallization and preliminary X-ray analysis of the C-terminal domain of δ-COP, a medium-sized subunit of the COPI complex involved in membrane trafficking". Acta Crystallographica Section F. 68 (Pt 7): 829–31. doi:10.1107/S1744309112022798. PMC 3388933. PMID 22750876.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000095139 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032096 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Archain 1". Pristupljeno 22. 6. 2016.

[UniProt-6] "UniProt, P48444". Pristupljeno 16. 8. 2021.

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