ARFGEF2

ARFGEF2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3L8N, 3SWV
Identifikatori
Aliasi	ARFGEF2
Vanjski ID-jevi	OMIM: 605371 MGI: 2139354 HomoloGene: 111880 GeneCards: ARFGEF2
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	49,036,693 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	166,739,972 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• guanyl-nucleotide exchange factor activity; • GABA receptor binding; • myosin binding; • GO:0001948, GO:0016582 vezivanje za proteine; • protein kinase A regulatory subunit binding;
Ćelijska komponenta	• citoplazma; • reciklirajući endosom; • citosol; • endozom; • Golđijev aparat; • projekcija ćelije; • membrana; • Golđijeva membrana; • dendritična kičma; • sinapsa; • centar organizacije mikrotubula; • međućelijske veze; • trans-Golđijeva mreža; • dendrit; • simetrična sinapsa; • asimetrična sinapsa; • perinuklearno područje citoplazme; • citoskelet; • GO:0016023 citoplazmatska vezikula; • aksonemalna mikrotubula;
Biološki proces	• endomembrane system organization; • GO:0007243 intracellular signal transduction; • regulation of ARF protein signal transduction; • endosome organization; • receptor recycling; • positive regulation of tumor necrosis factor production; • protein transport; • Golgi to plasma membrane transport; • Egzocitoza; • GO:0015915 transport; • regulation of molecular function; • vesicle-mediated transport;
	Izvori:Amigo / QuickGO
Ortolozi
	10564
	99371
	ENSG00000124198
	ENSMUSG00000074582
	Q9Y6D5
	A2A5R2
	NM_006420
	NM_001085495
	NP_006411
	NP_001078964
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Brefeldin A inhibirani protein razmjene guaninskog nukleotida 2 je protein koji kod ljudi kodiran genom ARFGEF2.^[5]^[6]

Funkcija[uredi | uredi izvor]

ADP-faktor ribozilacije (ARF) ima važnu ulogu u unutarćelijskom vezikulskom promrtut. Protein koji kodira ovaj gen uključen je u aktivaciju ARF-a, ubrzavanjem zamjene vezanog BDP-a GTP-om i uključen je u transport Golgijevog aparata. Sadrži domen Sec7, koji može biti odgovoran za njegovu aktivnost razmjene guanin-nukleotida, a također i za inhibiciju brefeldina A.^[6]

Interakcije[uredi | uredi izvor]

Dokazano je da ARFGEF2 ima interakcije sa ARFGEF1,^[7] PRKAR1A^[8] i PRKAR2A.^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124198 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074582 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
^ ^a ^b "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".
^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
^ ^a ^b Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma ARFGEF2 i stranica sa detaljima o genu ARFGEF2 u UCSC Genome Browseru.

Dopunska literatura[uredi | uredi izvor]

Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics. 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors". Methods in Enzymology. 345: 397–404. doi:10.1016/S0076-6879(02)45032-X. ISBN 9780121822460. PMID 11665623.
Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K (Mar 2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". The Journal of Biological Chemistry. 277 (11): 9468–73. doi:10.1074/jbc.M112427200. PMID 11777925.
Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K (Jun 2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins". Biochemical and Biophysical Research Communications. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.
Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA (Jan 2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex". Nature Genetics. 36 (1): 69–76. doi:10.1038/ng1276. PMID 14647276.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70". Proceedings of the National Academy of Sciences of the United States of America. 102 (8): 2784–9. doi:10.1073/pnas.0409871102. PMC 549493. PMID 15705715.
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V (Jan 2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia". The Journal of Comparative Neurology. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ (Mar 2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles". The Journal of Biological Chemistry. 282 (13): 9591–9. doi:10.1074/jbc.M607122200. PMID 17276987.
Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma". Proceedings of the National Academy of Sciences of the United States of America. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMC 1805514. PMID 17360629.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124198 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074582 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10212200-5] Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.

[entrez-6] "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".

[pmid10716990-7] Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.

[pmid12571360-8] Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.

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