ARPP-21

ARPP-21
Identifikatori
Aliasi	ARPP21
Vanjski ID-jevi	OMIM: 605488 MGI: 107562 HomoloGene: 32306 GeneCards: ARPP21
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	35,794,496 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	112,235,938 bp
Ontologija gena
Molekularna funkcija	• calmodulin binding; • nucleic acid binding; • molekularna funkcija;
Ćelijska komponenta	• citoplazma; • ćelijska komponenta;
Biološki proces	• cellular response to heat; • GO:0022610 biološki proces;
	Izvori:Amigo / QuickGO
Ortolozi
	10777
	74100
	ENSG00000172995
	ENSMUSG00000032503
	Q9UBL0
	Q9DCB4
NM_001025068; NM_001025069; NM_001267616; NM_001267617; NM_001267618;
	NM_001267619; NM_016300; NM_198399
NM_001177615; NM_001177616; NM_001177617; NM_001177618; NM_001177619;
	NM_001177620; NM_001177623; NM_028755; NM_033264
NP_001020239; NP_001020240; NP_001254545; NP_001254546; NP_001254547;
	NP_001254548; NP_057384; NP_938409
NP_001171086; NP_001171087; NP_001171088; NP_001171089; NP_001171090;
	NP_001171091; NP_001171094; NP_083031; NP_150289; NP_001348929; NP_001348930; NP_001348931; NP_001348932; NP_001348933; NP_001348934; NP_001348935; NP_001348936; NP_001348937; NP_001348938; NP_001348939; NP_001348940; NP_001348941; NP_001348942; NP_001348943; NP_001348944; NP_001348945; NP_001348946; NP_001348947; NP_001348948; NP_001348949; NP_001348950; NP_001348951; NP_001348952; NP_001348953; NP_001348954; NP_001348955; NP_001348956; NP_001348957; NP_001348958; NP_001348959; NP_001348960; NP_001348961; NP_001348962; NP_001348963; NP_001348964; NP_001348965; NP_001348966; NP_001348967; NP_001348968; NP_001348969; NP_001348970
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Ciklični AMP-regulirani 21 kD fosfoprotein, poznat i kao ARPP-21, jest ljudski gen na hromosomu 3.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 812 aminokiselina, а molekulska težina 89.196 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSEQGDLNQA	IAEEGGTEQE	TATPENGIVK	SESLDEEEKL	ELQRRLEAQN
QERRKSKSGA	GKGKLTRSLA	VCEESSARPG	GESLQDQESI	HLQLSSFSSL
QEEDKSRKDD	SEREKEKDKN	KDKTSEKPKI	RMLSKDCSQE	YTDSTGIDLH
EFLINTLKNN	SRDRMILLKM	EQEIIDFIAD	NNNHYKKFPQ	MSSYQRMLVH
RVAAYFGLDH	NVDQTGKSVI	INKTSSTRIP	EQRFCEHLKD	EKGEESQKRF
ILKRDNSSID	KEDNQQNRMH	PFRDDRRSKS	IEEREEEYQR	VRERIFAHDS
VCSQESLFVE	NSRLLEDSNI	CNETYKKRQL	FRGNRDGSGR	TSGSRQSSSE
NELKWSDHQR	AWSSTDSDSS	NRNLKPAMTK	TASFGGITVL	TRGDSTSSTR
STGKLSKAGS	ESSSSAGSSG	SLSRTHPPLQ	STPLVSGVAA	GSPGCVPYPE
NGIGGQVAPS	STSYILLPLE	AATGIPPGSI	LLNPHTGQPF	VNPDGTPAIY
NPPTSQQPLR	SAMVGQSQQQ	PPQQQPSPQP	QQQVQPPQPQ	MAGPLVTQRD
DVATQFGQMT	LSRQSSGETP	EPPSGPVYPS	SLMPQPAQQP	SYVIASTGQQ
LPTGGFSGSG	PPISQQVLQP	PPSPQGFVQQ	PPPAQMPVYY	YPSGQYPTST
TQQYRPMAPV	QYNAQRSQQM	PQAAQQAGYQ	PVLSGQQGFQ	GLIGVQQPPQ
SQNVINNQQG	TPVQSVMVSY	PTMSSYQVPM	TQGSQGLPQQ	SYQQPIMLPN
QAGQGSLPAT	GMPVYCNVTP	PTPQNNLRLI	GPHCPSSTVP	VMSASCRTNC
ASMSNAGWQV	KF

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172995 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032503 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ARPP-21 cyclic AMP-regulated phosphoprotein, 21 kD".
^ "UniProt, Q9UBL0" (jezik: engleski). Pristupljeno 1. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–2772. doi:10.1021/ac035352d. PMID 15144186.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P (2004). "A network of control mediated by regulator of calcium/calmodulin-dependent signaling". Science. 306 (5696): 698–701. doi:10.1126/science.1099961. PMID 15499021. S2CID 12127149. CS1 održavanje: nepreporučeni parametar (link)
Caporaso GL, Bibb JA, Snyder GL, Valle C, Rakhilin S, Fienberg AA, Hemmings HC, Nairn AC, Greengard P (2000). "Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia". Neuropharmacology. 39 (9): 1637–44. doi:10.1016/s0028-3908(99)00230-0. PMID 10854908. S2CID 11927459.
Nair AG, Bhalla US, Hellgren Kotaleski J (2016). "Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration". PLOS Comput Biol. 12 (9): e1005080. doi:10.1371/journal.pcbi.1005080. PMC 5008828. PMID 27584878.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma ARPP21 i stranica sa detaljima o genu ARPP21 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172995 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032503 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ARPP-21 cyclic AMP-regulated phosphoprotein, 21 kD".

[UniProt-6] "UniProt, Q9UBL0" (jezik: engleski). Pristupljeno 1. 10. 2021.

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