Arotinolol

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Arotinolol
Naziv lijeka Arotinolol
Grupa Blokatori β-receptora
Klasifikacija
ATC kodovi Nema
CAS registarski broj 41287-43-8
Dostupnost bez recepta: Ne
Stručne informacije
Hemijske osobine
Arotinolol.svg
Ime po IUPAC (RS)-5-(2-{[3-(tert-butilamino)-2-hidroksipropil]sulfanil}- 1,3-tiazol-4-il)tiofen-2-karboksamid
Sumarna formula C15H21N3O2S3
Molarna masa 371,54 g/mol
Farmakokinetičke osobine
Biološka raspoloživost 2 sata
Poluvrijeme eliminacije 10 sati
PubChem = 2239

Arotinolol (INN, u prometu pod trgovačkim nazivom Almarl) je lijek iz klase miješanih alfa/beta blokatora.[1] Također djeluje i kao β3 receptor agonist.[2]Jedna publikacija iz 1979 sugerira arotinolol kao prvoopisani u naučnoj literaturi, u Sumitomo Chemical kao "β-adrenergički blokirajući, antiaritmični spoj S-596.[3]

Upotreba[uredi | uredi izvor]

Arotinolol se upotrebljeva u liječenju visokog krvnog pritiska[4] i esencijalnog tremora.[5][6] Preporučeno doziranje je 10–30 mg dnevno.

Također pogledajte[uredi | uredi izvor]

Reference[uredi | uredi izvor]

  1. ^ Zhao, Jin; Golozoubova, Valeria; Cannon, Barbara; Nedergaard, Jan (July 2001). "Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes". Can J Physiol Pharmacol 79 (7): 585–593. PMID 11478592. doi:10.1139/cjpp-79-7-585. 
  2. ^ Takahashi, H; Yoshida, T; Nishimura, M; Nakanishi, T; Kondo, M; Yoshimura, M (September 1992). "Beta-3 Adrenergic Agonist, BRL-26830A, and Alpha/Beta Blocker, Arotinolol, Markedly Increase Regional Blood Flow in the Brown Adipose Tissue in Anesthetized Rats". Japanese Circulation Journal 56 (9): 936–42. PMID 1383578. doi:10.1253/jcj.56.936. 
  3. ^ Hara, Youichi; Sato, Etsuro; Miyagishi, Akira; Aono, Shunzi; Nakatani, Hiroshi (1979). "新しいβ-受容体遮断薬,dl-2-(3'-t-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)-thiazole hydrochloride (S-596) の薬理作用" [Pharmacological properties of dl-2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)thiazole hydrochloride (S-596), a new β-adrenergic blocking agent]. Folia Pharmacologica Japonica (English abstract) (jezik: Japanese): 707–720. ISSN 1347-8397. doi:10.1254/fpj.75.707. 
  4. ^ Wu, Haiying; Zhang, Yuqing; Huang, Jianfeng; Zhang, Yuhui; Liu, Guozhang; Sun, Ningling; Yu, Zhenqui; Zhou, Yanrong (September 2001). "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers" (PDF). Hypertension Research 24 (5): 605–10. ISSN 1348-4214. PMID 11675958. doi:10.1291/hypres.24.605. 
  5. ^ Lee, Kwang-Soo; Kim, Joong-Seok; Kim, Jae-Woo; Lee, Won-Yong; Jeon, Beum-Seok; Kim, Dongjae (August 2003). "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism & Related Disorders 9 (6): 341–347. PMID 12853233. doi:10.1016/S1353-8020(03)00029-4. 
  6. ^ "Almarl (アルマール) Arotinolol HCl Tablets. Full Prescribing Information". Sumitomo Dainippon Pharma Co., Ltd. Pristupljeno 6 March 2016. 

Vanjski linkovi[uredi | uredi izvor]