BMP3

BMP3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2QCQ
Identifikatori
Aliasi	BMP3
Vanjski ID-jevi	OMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	81,057,627 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	99,032,255 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• cytokine activity; • BMP receptor binding; • transforming growth factor beta receptor binding; • growth factor activity; • signaling receptor binding;
Ćelijska komponenta	• extracellular region; • Egzosom; • Vanćelijsko;
Biološki proces	• regulation of apoptotic process; • skeletal system development; • Ćelijska diferencijacija; • regulation of MAPK cascade; • SMAD protein signal transduction; • cell development; • ossification; • cell-cell signaling; • positive regulation of pathway-restricted SMAD protein phosphorylation; • BMP signaling pathway; • multicellular organism development; • cartilage development; • osteoblast differentiation; • regulation of signaling receptor activity;
	Izvori:Amigo / QuickGO
Ortolozi
	651
	110075
	ENSG00000152785
	ENSMUSG00000029335
	P12645
	Q8BHE5
	NM_001201
	NM_173404; NM_001310677
	NP_001192
	NP_001297606; NP_775580
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Koštanomorfogenetski protein 3, znan i kao osteogenin, jest protein koji je kod ljudi kodiran genom BMP3 sa hromosoma 4.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 472 aminokiseline, a molekulska težina 53.372 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAGASRLLFL	WLGCFCVSLA	QGERPKPPFP	ELRKAVPGDR	TAGGGPDSEL
QPQDKVSEHM	LRLYDRYSTV	QAARTPGSLE	GGSQPWRPRL	LREGNTVRSF
RAAAAETLER	KGLYIFNLTS	LTKSENILSA	TLYFCIGELG	NISLSCPVSG
GCSHHAQRKH	IQIDLSAWTL	KFSRNQSQLL	GHLSVDMAKS	HRDIMSWLSK
DITQLLRKAK	ENEEFLIGFN	ITSKGRQLPK	RRLPFPEPYI	LVYANDAAIS
EPESVVSSLQ	GHRNFPTGTV	PKWDSHIRAA	LSIERRKKRS	TGVLLPLQNN
ELPGAEYQYK	KDEVWEERKP	YKTLQAQAPE	KSKNKKKQRK	GPHRKSQTLQ
FDEQTLKKAR	RKQWIEPRNC	ARRYLKVDFA	DIGWSEWIIS	PKSFDAYYCS
GACQFPMPKS	LKPSNHATIQ	SIVRAVGVVP	GIPEPCCVPE	KMSSLSILFF
DENKNVVLKV	YPNMTVESCA	CR

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom član je natporodice transformirajući faktor rasta beta. Kao i drugi koštanomorfogenetski proteini (BMP) je poznat po svojoj sposobnosti da indukuje razvoj kostiju i hrskavice. To je disulfid-vezani homodimer. Negativno regulira gustinu kostiju. BMP3 je antagonist drugim BMP u diferencijaciji osteogenih progenitora. Jako je eksprimiran u slomljenim tkivima.

Kancer[uredi | uredi izvor]

BMP3 je hipermetiliran u mnogim slučajevima kolorektimskog karcinoma (CRC) i stoga se zajedno s drugim hipermetiliranim genima može koristiti kao biomarker za otkrivanje CRC u ranoj fazi.^[6]^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152785 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".
^ Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (juni 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.
^ Kormi SM, Ardehkhani S, Kerachian MA (novembar 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.

Dopunska literatura[uredi | uredi izvor]

Dickinson ME, Kobrin MS, Silan CM, Kingsley DM, Justice MJ, Miller DA, Ceci JD, Lock LF, Lee A, Buchberg AM (mart 1990). "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci". Genomics. 6 (3): 505–20. doi:10.1016/0888-7543(90)90480-I. PMID 1970330.
Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney JM, Kaplan FS (februar 1991). "Bone morphogenetic protein: chromosomal localization of human genes for BMP1, BMP2A, and BMP3". Genomics. 9 (2): 283–9. doi:10.1016/0888-7543(91)90254-C. PMID 2004778.
Paralkar VM, Nandedkar AK, Pointer RH, Kleinman HK, Reddi AH (oktobar 1990). "Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen". The Journal of Biological Chemistry. 265 (28): 17281–4. PMID 2211625.
Rosen V, Wozney JM, Wang EA, Cordes P, Celeste A, McQuaid D, Kurtzberg L (1990). "Purification and molecular cloning of a novel group of BMPs and localization of BMP mRNA in developing bone". Connective Tissue Research. 20 (1–4): 313–9. doi:10.3109/03008208909023902. PMID 2612162.
Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA (decembar 1988). "Novel regulators of bone formation: molecular clones and activities". Science. 242 (4885): 1528–34. doi:10.1126/science.3201241. PMID 3201241.
Faucheux C, Ulysse F, Bareille R, Reddi AH, Amédée J (decembar 1997). "Opposing actions of BMP3 and TGF beta 1 in human bone marrow stromal cell growth and differentiation". Biochemical and Biophysical Research Communications. 241 (3): 787–93. doi:10.1006/bbrc.1997.7792. PMID 9434787.
Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V, Lyons KM (januar 2001). "Bone morphogenetic protein-3 is a negative regulator of bone density". Nature Genetics. 27 (1): 84–8. doi:10.1038/83810. PMID 11138004. S2CID 205097212.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (oktobar 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
Kloen P, Di Paola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ (septembar 2003). "BMP signaling components are expressed in human fracture callus". Bone. 33 (3): 362–71. doi:10.1016/S8756-3282(03)00191-1. PMID 13678778.
Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (septembar 2004). "Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery". Gene Therapy. 11 (17): 1312–20. doi:10.1038/sj.gt.3302298. PMID 15269709.
Chen AL, Fang C, Liu C, Leslie MP, Chang E, Di Cesare PE (novembar 2004). "Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage". Journal of Orthopaedic Research. 22 (6): 1188–92. doi:10.1016/j.orthres.2004.02.013. PMID 15475196. S2CID 11544281.

Vanjski linkivi[uredi | uredi izvor]

Lokacija ljudskog genoma BMP3 i stranica sa detaljima o genu BMP3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152785 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029335 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BMP3 bone morphogenetic protein 3 (osteogenic)".

[Rasmussen_2016-6] Rasmussen SL, Krarup HB, Sunesen KG, Pedersen IS, Madsen PH, Thorlacius-Ussing O (juni 2016). "Hypermethylated DNA as a biomarker for colorectal cancer: a systematic review". Colorectal Disease. 18 (6): 549–61. doi:10.1111/codi.13336. PMID 26998585. S2CID 25724654.

[7] Kormi SM, Ardehkhani S, Kerachian MA (novembar 2017). "New insights into colorectal cancer screening and early detection tests". Colorectal Cancer. 6 (2): 63–68. doi:10.2217/crc-2017-0007.

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