C1QTNF3

C1QTNF3
Identifikatori
Aliasi	C1QTNF3
Vanjski ID-jevi	OMIM: 612045 MGI: 1932136 HomoloGene: 12788 GeneCards: C1QTNF3
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	34,043,213 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	10,980,236 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • molekularna funkcija;
Ćelijska komponenta	• extracellular region; • collagen; • Egzosom; • membrana; • Vanćelijsko;
Biološki proces	• cellular triglyceride homeostasis; • negative regulation of monocyte chemotactic protein-1 production; • negative regulation of gluconeogenesis; • protein trimerization; • fat cell differentiation; • negative regulation of inflammatory response; • negative regulation of gene expression; • positive regulation of adiponectin secretion; • negative regulation of NIK/NF-kappaB signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	114899
	81799
	ENSG00000082196
	ENSMUSG00000058914
	Q9BXJ4
	Q9ES30
	NM_181435; NM_030945
	NM_001204134; NM_030888
	NP_112207; NP_852100
	NP_001191063; NP_112150
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Srodni faktor proteina 3 komponente C1q tumorske nekroze jest protein koji je kod ljudi kodiran genom C1QTNF3.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 246 aminokiselina, а molekulska težina 26.994 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MLWRQLIYWQ	LLALFFLPFC	LCQDEYMESP	QTGGLPPDCS	KCCHGDYSFR
GYQGPPGPPG	PPGIPGNHGN	NGNNGATGHE	GAKGEKGDKG	DLGPRGERGQ
HGPKGEKGYP	GIPPELQIAF	MASLATHFSN	QNSGIIFSSV	ETNIGNFFDV
MTGRFGAPVS	GVYFFTFSMM	KHEDVEEVYV	YLMHNGNTVF	SMYSYEMKGK
SDTSSNHAVL	KLAKGDEVWL	RMGNGALHGD	HQRFSTFAGF	LLFETK

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000082196 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058914 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wölfing B, Buechler C, Weigert J, Neumeier M, Aslanidis C, Schöelmerich J, Schäffler A (Jul 2008). "Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines". Obesity. 16 (7): 1481–1486. doi:10.1038/oby.2008.206. PMID 18421280. S2CID 40979522.
^ "Entrez Gene: C1QTNF3 C1q and tumor necrosis factor related protein 3".
^ "UniProt, Q9BXJ4" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Akiyama H, Furukawa S, Wakisaka S, Maeda T (Oct 2007). "CTRP3/cartducin promotes proliferation and migration of endothelial cells". Molecular and Cellular Biochemistry. 304 (1–2): 243–248. doi:10.1007/s11010-007-9506-6. PMID 17534697. S2CID 25647563.
Wurm S, Neumeier M, Weigert J, Schäffler A, Buechler C (2007). "Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults". Cardiovascular Diabetology. 6: 7. doi:10.1186/1475-2840-6-7. PMC 1804262. PMID 17311679.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
Schäffler A, Ehling A, Neumann E, Herfarth H, Paul G, Tarner I, Gay S, Schölmerich J, Müller-Ladner U (Nov 2003). "Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1630 (2–3): 123–9. doi:10.1016/j.bbaexp.2003.08.013. PMID 14654242.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S (Feb 2001). "Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development". The Journal of Biological Chemistry. 276 (5): 3628–3634. doi:10.1074/jbc.M007898200. PMID 11071891.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma C1QTNF3 i stranica sa detaljima o genu C1QTNF3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000082196 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058914 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18421280-5] Wölfing B, Buechler C, Weigert J, Neumeier M, Aslanidis C, Schöelmerich J, Schäffler A (Jul 2008). "Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines". Obesity. 16 (7): 1481–1486. doi:10.1038/oby.2008.206. PMID 18421280. S2CID 40979522.

[entrez-6] "Entrez Gene: C1QTNF3 C1q and tumor necrosis factor related protein 3".

[UniProt-7] "UniProt, Q9BXJ4" (jezik: engleski). Pristupljeno 13. 10. 2021.

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