C8orf4

C8orf4
Identifikatori
Aliasi	TCIM
Vanjski ID-jevi	OMIM: 607702 MGI: 1916318 HomoloGene: 10590 GeneCards: TCIM
Lokacija gena (čovjek)
Hrom.	Hromosom 8 (čovjek)
Kraj	40,155,310 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	24,929,000 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • Notch binding;
Ćelijska komponenta	• citoplazma; • nuclear speck; • Jedarce; • jedro; • nukleoplazma; • citosol; • ćelijska membrana; • intracellular anatomical structure;
Biološki proces	• regulation of cell cycle G1/S phase transition; • endothelial cell activation involved in immune response; • cellular response to heat; • regulation of DNA-templated transcription in response to stress; • regulation of hemopoiesis; • negative regulation of Notch signaling pathway; • GO:0097285 apoptoza; • positive regulation of protein kinase A signaling; • negative regulation of apoptotic process; • positive regulation of protein kinase C activity; • positive regulation of NIK/NF-kappaB signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	56892
	69068
	ENSG00000176907
	ENSMUSG00000056313
	Q9NR00
	Q9D915
	NM_020130
	NM_026931
	NP_064515
	NP_081207
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

TCIM je protein koji je kod ljudi kodiran genom TCIM.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 106 aminokiselina, а molekulska težina 12.337 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKAKRSHQAV	IMSTSLRVSP	SIHGYHFDTA	SRKKAVGNIF	ENTDQESLER
LFRNSGDKKA	EERAKIIFAI	DQDVEEKTRA	LMALKKRTKD	KLFQFLKLRK
YSIKVH

Funkcija[uredi | uredi izvor]

Ovaj gen kodira mali, monomerni, pretežno nestrukturirani protein (106 aminokiselina, 12,3 kDa, izoelektrična tačka 9,39).^[8] To je pozitivni regulator signalnog puta Wnt / beta-katenina. Ovaj protein stupa u interakciju s represorom beta-katenin posredovane transkripcije na jedarnim pjegama. Smatra se da konkurentno blokira interakcije represora s beta-kateninom, što rezultira povećanom regulacijom beta-kateninskih ciljnih gena.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176907 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056313 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chua EL, Young L, Wu WM, Turtle JR, Dong Q (novembar 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.
^ ^a ^b "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".
^ "UniProt, Q9NR00". Pristupljeno 14. 9. 2021.
^ Kozlowski LP (oktobar 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290. Arhivirano s originala, 29. 4. 2013. Pristupljeno 22. 9. 2021.

Dopunska literatura[uredi | uredi izvor]

Bonaldo MF, Lennon G, Soares MB (septembar 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK (april 2004). "TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer". Cancer Research. 64 (8): 2766–73. doi:10.1158/0008-5472.CAN-03-2093. PMID 15087392.
Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD (august 2004). "C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer". International Journal of Cancer. 111 (1): 72–5. doi:10.1002/ijc.20235. PMID 15185345. S2CID 19983783.
Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I (januar 2006). "TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby". Cancer Research. 66 (2): 723–8. doi:10.1158/0008-5472.CAN-05-3124. PMID 16424001.
Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I (juni 2006). "TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer". Clinical Cancer Research. 12 (11 Pt 1): 3541–8. doi:10.1158/1078-0432.CCR-05-2440. PMID 16740781.
Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP (decembar 2006). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer". Cancer Research. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP (septembar 2007). "Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways". International Journal of Cancer. 121 (6): 1265–73. doi:10.1002/ijc.22831. PMID 17520678. S2CID 25292320.
Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I (august 2007). "TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response". Biochemical and Biophysical Research Communications. 360 (2): 447–52. doi:10.1016/j.bbrc.2007.06.077. PMID 17603013.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma C8orf4 i stranica sa detaljima o genu C8orf4 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000176907 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056313 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11056052-5] Chua EL, Young L, Wu WM, Turtle JR, Dong Q (novembar 2000). "Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer". Genomics. 69 (3): 342–7. doi:10.1006/geno.2000.6348. PMID 11056052.

[entrez-6] "Entrez Gene: C8orf4 chromosome 8 open reading frame 4".

[UniProt-7] "UniProt, Q9NR00". Pristupljeno 14. 9. 2021.

[Kozlowski-8] Kozlowski LP (oktobar 2016). "IPC - Isoelectric Point Calculator". Biology Direct. 11 (1): 55. doi:10.1186/s13062-016-0159-9. PMC 5075173. PMID 27769290. Arhivirano s originala, 29. 4. 2013. Pristupljeno 22. 9. 2021.

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