S Wikipedije, slobodne enciklopedije
CDK5 i ABL1 enzimski supstrat 1 jest protein koji je kod ljudi kodiran genom CABLES1 .[5] [6]
Dužina polipeptidnog lanca je 633 aminokiseline , a molekulska masa — 67.599[7] ciklin-ovisna kinaza (CDK)-vezujući protein koji ima ulogu u proliferaciji i/ili diferencijaciji ćelija (prema: OMIM .[6] gen za supresiju tumora koji gubljenjem (mutacijama, nokautom, nokdaunom ili inaktivacijom) može dovesti do kolorektumskog karcinoma CRC.
Simboli
10 20 30 40 50 MAAAAAAATT AACSSGSAGT DAAGASGLQQ PPPQPQPQPA AAAPAQPPPE PPRKPRMDPR RRQAALSFLT NISLDGRLPP QDAEWGGGEE GGAAKPGAGG ACGARTRFSL LAAAERGGCI ALAAPGTPAA GLAAGSGPCL PQPSSLPPLI PGGHATVSGP GVARGFASPL GAGRASGEQW QPPRPAPLAA CAQLQLLDGS GAAGQEELEE DDAFISVQVP AAAFLGSGTP GSGSGSRGRL NSFTQGILPI AFSRPTSQNY CSLEQPGQGG STSAFEQLQR SRRRLISQRS SLETLEDIEE NAPLRRCRTL SGSPRPKNFK KIHFIKNMRQ HDTRNGRIVL ISGRRSFCSI FSVLPYRDST QVGDLKLDGG RQSTGAVSLK EIIGLEGVEL GADGKTVSYT QFLLPTNAFG ARRNTIDSTS SFSQFRNLSH RSLSIGRASG TQGSLDTGSD LGDFMDYDPN LLDDPQWPCG KHKRVLIFPS YMTTVIDYVK PSDLKKDMNE TFKEKFPHIK LTLSKIRSLK REMRKLAQED CGLEEPTVAM AFVYFEKLAL KGKLNKQNRK LCAGACVLLA AKIGSDLKKH EVKHLIDKLE EKFRLNRREL IAFEFPVLVA LEFALHLPEH EVMPHYRRLV QSS
^ a b c GRCh38: Ensembl release 89: ENSG00000134508 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040957 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc Natl Acad Sci U S A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . ^ a b "Entrez Gene: CABLES1 Cdk5 and Abl enzyme substrate 1" .^ "UniProt, Q8TDN4" (jezik: англ.). Pristupljeno 12. 9. 2017 .CS1 održavanje: nepoznati jezik (link )
Matsuoka M, Matsuura Y, Semba K, Nishimoto I (2000). "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo". Biochem. Biophys. Res. Commun . 273 (2): 442–7. doi :10.1006/bbrc.2000.2965 . PMID 10873625 . Zukerberg LR, Patrick GN, Nikolic M, et al. (2000). "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth" (PDF) . Neuron . 26 (3): 633–46. doi :10.1016/S0896-6273(00)81200-3 . hdl :1721.1/83489 PMID 10896159 . S2CID 15142577 . Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun . 286 (5): 1045–50. doi :10.1006/bbrc.2001.5493 . PMID 11527406 . Wu CL, Kirley SD, Xiao H, et al. (2001). "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers". Cancer Res . 61 (19): 7325–32. PMID 11585773 . Tsuji K, Mizumoto K, Yamochi T, et al. (2002). "Differential effect of ik3-1/cables on p53- and p73-induced cell death" . J. Biol. Chem . 277 (4): 2951–7. doi :10.1074/jbc.M108535200 PMID 11706030 . Yamochi T, Semba K, Tsuji K, et al. (2002). "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem . 268 (23): 6076–82. doi :10.1046/j.0014-2956.2001.02555.x . PMID 11733001 . Sato H, Nishimoto I, Matsuoka M (2002). "ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl". Biochim. Biophys. Acta . 1574 (2): 157–63. doi :10.1016/S0167-4781(01)00367-0 . PMID 11955625 . Tan D, Kirley S, Li Q, et al. (2003). "Loss of cables protein expression in human non-small cell lung cancer: a tissue microarray study" . Hum. Pathol . 34 (2): 143–9. doi :10.1053/hupa.2003.26 . PMID 12612882 . Dong Q, Kirley S, Rueda B, et al. (2004). "Loss of cables, a novel gene on chromosome 18q, in ovarian cancer" . Mod. Pathol . 16 (9): 863–8. doi :10.1097/01.MP.0000084434.88269.0A PMID 13679449 . Matsuoka M, Sudo H, Tsuji K, et al. (2004). "ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways". Biochem. Biophys. Res. Commun . 312 (2): 520–9. doi :10.1016/j.bbrc.2003.10.142 . PMID 14637168 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Zukerberg LR, DeBernardo RL, Kirley SD, et al. (2004). "Loss of cables, a cyclin-dependent kinase regulatory protein, is associated with the development of endometrial hyperplasia and endometrial cancer" . Cancer Res . 64 (1): 202–8. doi :10.1158/0008-5472.CAN-03-2833 PMID 14729625 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zhang H, Duan HO, Kirley SD, et al. (2006). "Aberrant splicing of cables gene, a CDK regulator, in human cancers" . Cancer Biol. Ther . 4 (11): 1211–5. doi :10.4161/cbt.4.11.2085 PMID 16177568 . Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18" . Nature . 437 (7058): 551–5. doi :10.1038/nature03983 PMID 16177791 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett . 580 (27): 6464–70. doi :10.1016/j.febslet.2006.10.065 . PMID 17101133 . S2CID 20005197 . 
