CCDC88A

CCDC88A
Identifikatori
Aliasi	CCDC88A
Vanjski ID-jevi	OMIM: 609736 MGI: 1925177 HomoloGene: 41180 GeneCards: CCDC88A
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	55,419,895 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	29,460,808 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • phosphatidylinositol binding; • actin binding; • microtubule binding; • protein kinase B binding; • dynein light intermediate chain binding; • G-protein gamma-subunit binding;
Ćelijska komponenta	• citoplazma; • Golđijev aparat; • projekcija ćelije; • Endoplazmatski retikulum; • lamellipodium; • membrana; • GO:0016023 citoplazmatska vezikula; • citosol; • ćelijska membrana; • cell leading edge; • centrosom; • Centriole; • citoskelet; • ciliary basal body; • COPI-coated Golgi to ER transport vesicle;
Biološki proces	• regulation of actin cytoskeleton organization; • nervous system development; • Replikacija DNK; • membrane organization; • Ćelijska migracija; • lamellipodium assembly; • activation of protein kinase B activity; • regulation of DNA replication; • TOR signaling; • regulation of protein phosphorylation; • regulation of cell population proliferation; • regulation of neuron projection development; • cell projection organization; • cytoskeleton-dependent intracellular transport; • cytoplasmic microtubule organization; • positive regulation of cilium assembly; • positive regulation of protein localization to cilium;
	Izvori:Amigo / QuickGO
Ortolozi
	55704
	108686
	ENSG00000115355
	ENSMUSG00000032740
	Q3V6T2
	Q5SNZ0
	NM_001135597; NM_001254943; NM_018084; NM_001365480
	NM_176841; NM_001363368; NM_001363369
	NP_001129069; NP_001241872; NP_060554; NP_001352409
	NP_789811; NP_001350297; NP_001350298
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Girdin jest protein domena upredene zavojnice, koji je kod ljudi kodiran genom CCDC88A' sa hromosoma 2.^[5]^[6]^[7]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.871 aminokiselina, a molekulska težina 216.042 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MENEIFTPLL	EQFMTSPLVT	WVKTFGPLAA	GNGTNLDEYV	ALVDGVFLNQ
VMLQINPKLE	SQRVNKKVNN	DASLRMHNLS	ILVRQIKFYY	QETLQQLIMM
SLPNVLIIGK	NPFSEQGTEE	VKKLLLLLLG	CAVQCQKKEE	FIERIQGLDF
DTKAAVAAHI	QEVTHNQENV	FDLQWMEVTD	MSQEDIEPLL	KNMALHLKRL
IDERDEHSET	IIELSEERDG	LHFLPHASSS	AQSPCGSPGM	KRTESRQHLS
VELADAKAKI	RRLRQELEEK	TEQLLDCKQE	LEQMEIELKR	LQQENMNLLS
DARSARMYRD	ELDALREKAV	RVDKLESEVS	RYKERLHDIE	FYKARVEELK
EDNQVLLETK	TMLEDQLEGT	RARSDKLHEL	EKENLQLKAK	LHDMEMERDM
DRKKIEELME	ENMTLEMAQK	QSMDESLHLG	WELEQISRTS	ELSEAPQKSL
GHEVNELTSS	RLLKLEMENQ	SLTKTVEELR	TTVDSVEGNA	SKILKMEKEN
QRLSKKVEIL	ENEIVQEKQS	LQNCQNLSKD	LMKEKAQLEK	TIETLRENSE
RQIKILEQEN	EHLNQTVSSL	RQRSQISAEA	RVKDIEKENK	ILHESIKETS
SKLSKIEFEK	RQIKKELEHY	KEKGERAEEL	ENELHHLEKE	NELLQKKITN
LKITCEKIEA	LEQENSELER	ENRKLKKTLD	SFKNLTFQLE	SLEKENSQLD
EENLELRRNV	ESLKCASMKM	AQLQLENKEL	ESEKEQLKKG	LELLKASFKK
TERLEVSYQG	LDIENQRLQK	TLENSNKKIQ	QLESELQDLE	MENQTLQKNL
EELKISSKRL	EQLEKENKSL	EQETSQLEKD	KKQLEKENKR	LRQQAEIKDT
TLEENNVKIG	NLEKENKTLS	KEIGIYKESC	VRLKELEKEN	KELVKRATID
IKTLVTLRED	LVSEKLKTQQ	MNNDLEKLTH	ELEKIGLNKE	RLLHDEQSTD
DSRYKLLESK	LESTLKKSLE	IKEEKIAALE	ARLEESTNYN	QQLRQELKTV
KKNYEALKQR	QDEERMVQSS	PPISGEDNKW	ERESQETTRE	LLKVKDRLIE
VERNNATLQA	EKQALKTQLK	QLETQNNNLQ	AQILALQRQT	VSLQEQNTTL
QTQNAKLQVE	NSTLNSQSTS	LMNQNAQLLI	QQSSLENENE	SVIKEREDLK
SLYDSLIKDH	EKLELLHERQ	ASEYESLISK	HGTLKSAHKN	LEVEHRDLED
RYNQLLKQKG	QLEDLEKMLK	VEQEKMLLEN	KNHETVAAEY	KKLCGENDRL
NHTYSQLLKE	TEVLQTDHKN	LKSLLNNSKL	EQTRLEAEFS	KLKEQYQQLD
ITSTKLNNQC	ELLSQLKGNL	EEENRHLLDQ	IQTLMLQNRT	LLEQNMESKD
LFHVEQRQYI	DKLNELRRQK	EKLEEKIMDQ	YKFYDPSPPR	RRGNWITLKM
RKLIKSKKDI	NRERQKSLTL	TPTRSDSSEG	FLQLPHQDSQ	DSSSVGSNSL
EDGQTLGTKK	SSMVALKRLP	FLRNRPKDKD	KMKACYRRSM	SMNDLVQSMV
LAGQWTGSTE	NLEVPDDIST	GKRRKELGAM	AFSTTAINFS	TVNSSAGFRS
KQLVNNKDTT	SFEDISPQGV	SDDSSTGSRV	HASRPASLDS	GRTSTSNSNN
NASLHEVKAG	AVNNQSRPQS	HSSGEFSLLH	DHEAWSSSGS	SPIQYLKRQT
RSSPVLQHKI	SETLESRHHK	IKTGSPGSEV	VTLQQFLEES	NKLTSVQIKS
SSQENLLDEV	MKSLSVSSDF	LGKDKPVSCG	LARSVSGKTP	GDFYDRRTTK
PEFLRPGPRK	TEDTYFISSA	GKPTPGTQGK	IKLVKESSLS	RQSKDSNPYA
TLPRASSVIS	TAEGTTRRTS	IHDFLTKDSR	LPISVDSPPA	AADSNTTAAS
NVDKVQESRN	SKSRSREQQS	S

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115355 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032740 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.
^ Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (maj 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.
^ "Entrez Gene: KIAA1212 KIAA1212".
^ "UniProt, Q3V6T2" (jezik: engleski). Pristupljeno 16. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Kitamura T, Asai N, Enomoto A, et al. (2008). "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin". Nat. Cell Biol. 10 (3): 329–37. doi:10.1038/ncb1695. PMID 18264090. S2CID 23157573.
Enomoto A, Murakami H, Asai N, et al. (2005). "Akt/PKB regulates actin organization and cell motility via Girdin/APE". Dev. Cell. 9 (3): 389–402. doi:10.1016/j.devcel.2005.08.001. PMID 16139227.
Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.

Vanjski linkovi[uredi | uredi izvor]

DISC1 Players Gird For Adult Neurodevelopment - Schizophrenia Research Forum, 8 oct 2009
Lokacija ljudskog genoma CCDC88A i stranica sa detaljima o genu CCDC88A u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115355 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032740 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15749703-5] Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG (Jun 2005). "Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles". J Biol Chem. 280 (23): 22012–20. doi:10.1074/jbc.M501833200. PMID 15749703.

[pmid15753085-6] Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T (maj 2005). "A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis". J Biol Chem. 280 (18): 18525–35. doi:10.1074/jbc.M500586200. PMID 15753085.

[entrez-7] "Entrez Gene: KIAA1212 KIAA1212".

[UniProt-8] "UniProt, Q3V6T2" (jezik: engleski). Pristupljeno 16. 11. 2021.

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