CCT5

CCT5
Identifikatori
Aliasi	CCT5
Vanjski ID-jevi	OMIM: 610150 MGI: 107185 HomoloGene: 6287 GeneCards: CCT5
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	10,266,389 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	31,601,950 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • G-protein beta-subunit binding; • GO:0001948, GO:0016582 vezivanje za proteine; • beta-tubulin binding; • ATP binding; • protein folding chaperone activity; • unfolded protein binding; • mRNA 3'-UTR binding; • mRNA 5'-UTR binding;
Ćelijska komponenta	• cell body; • centrosom; • myelin sheath; • centar organizacije mikrotubula; • zona pellucida receptor complex; • Jedarce; • TRiC; • Mikrotubula; • Egzosom; • citoskelet; • citoplazma; • citosol;
Biološki proces	• positive regulation of protein localization to Cajal body; • positive regulation of establishment of protein localization to telomere; • response to virus; • protein stabilization; • positive regulation of telomere maintenance via telomerase; • toxin transport; • Savijanje proteina; • positive regulation of telomerase RNA localization to Cajal body; • binding of sperm to zona pellucida; • 'de novo' protein folding; • chaperone-mediated protein folding;
	Izvori:Amigo / QuickGO
Ortolozi
	22948
	12465
	ENSG00000150753
	ENSMUSG00000022234
	P48643
	P80316
	NM_001306153; NM_001306154; NM_001306155; NM_001306156; NM_012073
	NM_007637; NM_001348035
	NP_001293082; NP_001293083; NP_001293084; NP_001293085; NP_036205
	NP_001334964; NP_031663
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica epsilon T-kompleksnog proteina 1 je protein koji je kod ljudi kodiran genom CCT5 gen.^[5]

Funkcija[uredi | uredi izvor]

Ovaj gen kodira molekulski šaperon, koji je član kompleksa TRiC. Ovaj kompleks sastoji se od dva identična složena prstena, od kojih svaki sadrži po osam različitih proteina. Nerazvijeni polipeptidi ulaze u središnju šupljinu kompleksa i savijaju se na način ovisan o ATP-u. Kompleks savija različite proteine, uključujući aktin i tubulin. Uočene su alternativne transkripcijske spojne varijante ovog gena, ali nisu detaljno okarakterizirane.^[5]

Interakcije[uredi | uredi izvor]

Pokazano je da CCT5 (gen) stupa u interakcije sa PPP4C.^[6]^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150753 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022234 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)".
^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. Arhivirano s originala (PDF), 2. 3. 2021. Pristupljeno 28. 2. 2021.

Dopunska literatura[uredi | uredi izvor]

Roobol A, Holmes FE, Hayes NV, Baines AJ, Carden MJ (Apr 1995). "Cytoplasmic chaperonin complexes enter neurites developing in vitro and differ in subunit composition within single cells". Journal of Cell Science. 108 (4): 1477–88. PMID 7615668.
Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
Liou AK, Willison KR (Jul 1997). "Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes". The EMBO Journal. 16 (14): 4311–6. doi:10.1093/emboj/16.14.4311. PMC 1170057. PMID 9250675.
Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A (Jul 1999). "SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1)". Proceedings of the National Academy of Sciences of the United States of America. 96 (14): 8070–3. doi:10.1073/pnas.96.14.8070. PMC 22189. PMID 10393949.
Yanaka N, Kobayashi K, Wakimoto K, Yamada E, Imahie H, Imai Y, Mori C (maj 2000). "Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis". The Journal of Biological Chemistry. 275 (20): 14791–4. doi:10.1074/jbc.C901047199. PMID 10747865.
Yoo BC, Kim SH, Cairns N, Fountoulakis M, Lubec G (Jan 2001). "Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease". Biochemical and Biophysical Research Communications. 280 (1): 249–58. doi:10.1006/bbrc.2000.4109. PMID 11162507.
Yoo BC, Vlkolinsky R, Engidawork E, Cairns N, Fountoulakis M, Lubec G (Apr 2001). "Differential expression of molecular chaperones in brain of patients with Down syndrome". Electrophoresis. 22 (6): 1233–41. doi:10.1002/1522-2683()22:6<1233::AID-ELPS1233>3.0.CO;2-M. PMID 11358150.
Yokota S, Yanagi H, Yura T, Kubota H (Sep 2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". European Journal of Biochemistry / FEBS. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
Ludwig A, Dietel M, Lage H (2003). "Identification of differentially expressed genes in classical and atypical multidrug-resistant gastric carcinoma cells". Anticancer Research. 22 (6A): 3213–21. PMID 12530067.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Lukov GL, Hu T, McLaughlin JN, Hamm HE, Willardson BM (Jun 2005). "Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly". The EMBO Journal. 24 (11): 1965–75. doi:10.1038/sj.emboj.7600673. PMC 1142607. PMID 15889144.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CCT5 i stranica sa detaljima o genu CCT5 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150753 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022234 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CCT5 chaperonin containing TCP1, subunit 5 (epsilon)".

[pmid18715871-6] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid16085932-7] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity" (PDF). Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932. Arhivirano s originala (PDF), 2. 3. 2021. Pristupljeno 28. 2. 2021.

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