CHMP1B

CHMP1B
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 3EAB, 4TXQ, 4TXR, 3JC1
Identifikatori
Aliasi	CHMP1B
Vanjski ID-jevi	OMIM: 606486 MGI: 1914314 HomoloGene: 41374 GeneCards: CHMP1B
Lokacija gena (čovjek) Hrom. Hromosom 18 (čovjek) Bend 18p11.21 Početak 11,851,413 bp Kraj 11,854,444 bp
Lokacija gena (miš) Hrom. Hromosom 18 (miš) Bend 18|18 E1 Početak 67,338,437 bp Kraj 67,340,960 bp
Ontologija gena Molekularna funkcija • protein domain specific binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina Ćelijska komponenta • citoplazma • ESCRT III complex • citosol • endozom • late endosome membrane • membrana • membrane coat • endosome membrane • Egzosom • jedro • midbody • multivesicular body Biološki proces • regulation of centrosome duplication • nucleus organization • establishment of protein localization • multivesicular body assembly • regulation of mitotic spindle assembly • Ćelijska dioba • protein transport • ćelijski ciklus • septum digestion after cytokinesis • mitotic metaphase plate congression • vacuolar transport • ESCRT III complex disassembly • GO:0015915 transport • viral budding via host ESCRT complex • endosome transport via multivesicular body sorting pathway • late endosome to vacuole transport • midbody abscission Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	57132	67064
Ensembl	ENSG00000255112	ENSMUSG00000109901
UniProt	Q7LBR1	Q99LU0
RefSeq (mRNK)	NM_020412	NM_024190
RefSeq (bjelančevina)	NP_065145	NP_077152
Lokacija (UCSC)	Chr 18: 11.85 – 11.85 Mb	Chr 18: 67.34 – 67.34 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Napunjeni viševezikulski tjelesni protein 1b je protein koji je kod ljudi kodiran genom CHMP1B.

Dužina polipeptidnog lanca je 199 aminokiselina, a molekulska težina — 22.109.

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10		20		30		40		50
MSNMEKHLFN		LKFAAKELSR		SAKKCDKEEK		AEKAKIKKAI		QKGNMEVARI
HAENAIRQKN		QAVNFLRMSA		RVDAVAARVQ		TAVTMGKVTK		SMAGVVKSMD
ATLKTMNLEK		ISALMDKFEH		QFETLDVQTQ		QMEDTMSSTT		TLTTPQNQVD
MLLQEMADEA		GLDLNMELPQ		GQTGSVGTSV		ASAEQDELSQ		RLARLRDQV

Reference

Vanjski linkovi

• Lokacija ljudskog genoma C10orf2 i stranica sa detaljima o genu C10orf2 u UCSC Genome Browseru.
• Lokacija ljudskog genoma CHMP1B i stranica sa detaljima o genu CHMP1B u UCSC Genome Browseru.
• Q7LBR1

Dopunska literatura

• Vuoristo JT, Berrettini WH, Ala-Kokko L (2001). "C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11". Cytogenet. Cell Genet. 93 (1–2): 19–22. doi:10.1159/000056940. PMID 11474171. S2CID 42139322.
• Stauffer DR, Howard TL, Nyun T, Hollenberg SM (2002). "CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression". J. Cell Sci. 114 (Pt 13): 2383–93. PMID 11559747.
• Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J. Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding". Cell. 114 (6): 689–99. doi:10.1016/S0092-8674(03)00653-6. PMID 14505569. S2CID 10733770.
• von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570. S2CID 16894972.
• Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Scott A, Gaspar J, Stuchell-Brereton MD, et al. (2005). "Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 13813–8. doi:10.1073/pnas.0502165102. PMC 1236530. PMID 16174732.
• Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
• Row PE, Liu H, Hayes S, et al. (2007). "The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation". J. Biol. Chem. 282 (42): 30929–37. doi:10.1074/jbc.M704009200. PMID 17711858.