CIC (gen)
Protein kapikua homologa je protein koji je kod ljudi kodiran genom CIC.[5][6][7]
Aminopkiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MYSAHRPLMP | ASSAASRGLG | MFVWTNVEPR | SVAVFPWHSL | VPFLAPSQPD | ||||
| PSVQPSEAQQ | PASHPVASNQ | SKEPAESAAV | AHERPPGGTG | SADPERPPGA | ||||
| TCPESPGPGP | PHPLGVVESG | KGPPPTTEEE | ASGPPGEPRL | DSETESDHDD | ||||
| AFLSIMSPEI | QLPLPPGKRR | TQSLSALPKE | RDSSSEKDGR | SPNKREKDHI | ||||
| RRPMNAFMIF | SKRHRALVHQ | RHPNQDNRTV | SKILGEWWYA | LGPKEKQKYH | ||||
| DLAFQVKEAH | FKAHPDWKWC | NKDRKKSSSE | AKPTSLGLAG | GHKETRERSM | ||||
| SETGTAAAPG | VSSELLSVAA | QTLLSSDTKA | PGSSSCGAER | LHTVGGPGSA | ||||
| RPRAFSHSGV | HSLDGGEVDS | QALQELTQMV | SGPASYSGPK | PSTQYGAPGP | ||||
| FAAPGEGGAL | AATGRPPLLP | TRASRSQRAA | SEDMTSDEER | MVICEEEGDD | ||||
| DVIADDGFGT | TDIDLKCKER | VTDSESGDSS | GEDPEGNKGF | GRKVFSPVIR | ||||
| SSFTHCRPPL | DPEPPGPPDP | PVAFGKGYGS | APSSSASSPA | SSSASAATSF | ||||
| SLGSGTFKAQ | ESGQGSTAGP | LRPPPPGAGG | PATPSKATRF | LPMDPATFRR | ||||
| KRPESVGGLE | PPGPSVIAAP | PSGGGNILQT | LVLPPNKEEQ | EGGGARVPSA | ||||
| PAPSLAYGAP | AAPLSRPAAT | MVTNVVRPVS | STPVPIASKP | FPTSGRAEAS | ||||
| PNDTAGARTE | MGTGSRVPGG | SPLGVSLVYS | DKKSAAATSP | APHLVAGPLL | ||||
| GTVGKAPATV | TNLLVGTPGY | GAPAPPAVQF | IAQGAPGGGT | TAGSGAGAGS | ||||
| GPNGPVPLGI | LQPGALGKAG | GITQVQYILP | TLPQQLQVAP | APAPAPGTKA | ||||
| AAPSGPAPTT | SIRFTLPPGT | STNGKVLAAT | APTPGIPILQ | SVPSAPPPKA | ||||
| QSVSPVQAPP | PGGSAQLLPG | KVLVPLAAPS | MSVRGGGAGQ | PLPLVSPPFS | ||||
| VPVQNGAQPP | SKIIQLTPVP | VSTPSGLVPP | LSPATLPGPT | SQPQKVLLPS | ||||
| STRITYVQSA | GGHALPLGTS | PASSQAGTVT | SYGPTSSVAL | GFTSLGPSGP | ||||
| AFVQPLLSAG | QAPLLAPGQV | GVSPVPSPQL | PPACAAPGGP | VITAFYSGSP | ||||
| APTSSAPLAQ | PSQAPPSLVY | TVATSTTPPA | ATILPKGPPA | PATATPAPTS | ||||
| PFPSATAGSM | TYSLVAPKAQ | RPSPKAPQKV | KAAIASIPVG | SFEAGASGRP | ||||
| GPAPRQPLEP | GPVREPTAPE | SELEGQPTPP | APPPLPETWT | PTARSSPPLP | ||||
| PPAEERTSAK | GPETMASKFP | SSSSDWRVPG | QGLENRGEPP | TPPSPAPAPA | ||||
| VAPGGSSESS | SGRAAGDTPE | RKEAAGTGKK | VKVRPPPLKK | TFDSVDNRVL | ||||
| SEVDFEERFA | ELPEFRPEEV | LPSPTLQSLA | TSPRAILGSY | RKKRKNSTDL | ||||
| DSAPEDPTSP | KRKMRRRSSC | SSEPNTPKSA | KCEGDIFTFD | RTGTEAEDVL | ||||
| GELEYDKVPY | SSLRRTLDQR | RALVMQLFQD | HGFFPSAQAT | AAFQARYADI | ||||
| FPSKVCLQLK | IREVRQKIMQ | AATPTEQPPG | AEAPLPVPPP | TGTAAAPAPT | ||||
| PSPAGGPDPT | SPSSDSGTAQ | AAPPLPPPPE | SGPGQPGWEG | APQPSPPPPG | ||||
| PSTAATGR |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000079432 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005442 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lee CJ, Chan WI, Cheung M, Cheng YC, Appleby VJ, Orme AT, Scotting PJ (Oct 2002). "CIC, a member of a novel subfamily of the HMG-box superfamily, is transiently expressed in developing granule neurons". Brain Res Mol Brain Res. 106 (1–2): 151–6. doi:10.1016/S0169-328X(02)00439-4. PMID 12393275.
- ^ Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas". J Neurooncol. 73 (2): 101–8. doi:10.1007/s11060-004-4598-2. PMID 15981098. S2CID 24938086.
- ^ "Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]".
Vanjski linkovi[uredi | uredi izvor]
- Lokacija ljudskog genoma CIC i stranica sa detaljima o genu CIC u UCSC Genome Browseru.
Dopunska literatura[uredi | uredi izvor]
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.