CKM

CKM
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1I0E
Identifikatori
Aliasi	CKM
Vanjski ID-jevi	OMIM: 123310 MGI: 88413 HomoloGene: 20432 GeneCards: CKM
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	45,322,875 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	19,156,766 bp
Ontologija gena
Molekularna funkcija	• transferase activity; • creatine kinase activity; • transferase activity, transferring phosphorus-containing groups; • nucleotide binding; • catalytic activity; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • kinase activity;
Ćelijska komponenta	• citoplazma; • citosol; • Vanćelijsko;
Biološki proces	• creatine metabolic process; • phosphocreatine biosynthetic process; • Fosforilacija;
	Izvori:Amigo / QuickGO
Ortolozi
	1158
	12715
	ENSG00000104879
	ENSMUSG00000030399
	P06732
	P07310
	NM_001824
	NM_007710
	NP_001815
	NP_031736
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Mišićna kreatin-kinaza, znana i kao MCK je kreatin-kinaza koju kod čovjekakodira gen MCK.^[5]

Struktura[uredi | uredi izvor]

Na slici desno prikazana je kristalna struktura mišićnog tipa M-CK monomera. In vivo, dva takva monomera simetrično se raspoređuju kako bi stvorili aktivni enzim MM-CK.

Funkcija[uredi | uredi izvor]

Protein kojeg kodira ovaj gen je citoplazmatski enzim uključen u homeostazu ćelijske energije. Kodirani protein reverzibilno katalizuje prenos "energetski bogatog" fosfat a između ATP i kreatina i između fosfo-kreatina i ADP-a. Njegova funkcionalna cjelina je MM-CK homodimer u prugastim (sarkomera ma) skeletnim i srčanim mišićima.

Klinički značaj[uredi | uredi izvor]

U srcu je, pored MM-CK homodimera, izražen i heterodimer MB-CK, koji se sastoji od jednog mišićnog (M-CK) i jedne podjedinice moždane kreatin-kinaze (B-CK). Potonji može biti važan serumski marker za infarkt miokarda, ako se oslobodi iz oštećenih ćelija miokarda u krv, gdje ga može otkriti kliničkohemijska preteaga.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104879 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030399 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (novembar 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. doi:10.1073/pnas.79.21.6589. PMC 347173. PMID 6959139.

Dopunska literatura[uredi | uredi izvor]

Zhao TJ, Yan YB, Liu Y, Zhou HM (2007). "The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase". J. Biol. Chem. 282 (16): 12022–9. doi:10.1074/jbc.M610363200. PMID 17303563.
Yamin C, Amir O, Sagiv M, et al. (2007). "ACE ID genotype affects blood creatine kinase response to eccentric exercise". J. Appl. Physiol. 103 (6): 2057–61. doi:10.1152/japplphysiol.00867.2007. PMID 17885020.
Warren GL, O'farrell L, Rogers KR, et al. (2006). "CK-MM autoantibodies: prevalence, immune complexes, and effect on CK clearance". Muscle Nerve. 34 (3): 335–46. doi:10.1002/mus.20594. PMID 16810680.
Hemmer W, Wallimann T (1993). "Functional aspects of creatine kinase in brain". Dev. Neurosci. 15 (3–5): 249–60. doi:10.1159/000111342. PMID 7805577.
Vikenes K, Andersen KS, Melberg T, et al. (2009). "Long-term prognostic value of creatine kinase-myocardial band mass after cardiac surgery in low-risk patients with stable angina". Cardiology. 113 (2): 122–31. doi:10.1159/000177949. PMID 19039220.
Muniesa CA, González-Freire M, Santiago C, et al. (2008). "World-class performance in lightweight rowing: Is it genetically influenced? A comparison with cyclists, runners and non-athletes". Br J Sports Med. 44 (12): 898–901. doi:10.1136/bjsm.2008.051680. PMID 18801770.
Wyss M, Kaddurah-Daouk R (2000). "Creatine and creatinine metabolism". Physiol. Rev. 80 (3): 1107–213. doi:10.1152/physrev.2000.80.3.1107. PMID 10893433.
Finsterer J, Stöllberger C, Krugluger W (2008). "Significance of CK-elevation in noncompaction with regard to cardiac and neuromuscular disease". Int. J. Cardiol. 130 (2): 174–9. doi:10.1016/j.ijcard.2007.08.038. PMID 18055044.
Fautsch MP, Vrabel AM, Johnson DH (2006). "The identification of myocilin-associated proteins in the human trabecular meshwork". Exp. Eye Res. 82 (6): 1046–52. doi:10.1016/j.exer.2005.09.016. PMID 16289162.
Heled Y, Bloom MS, Wu TJ, et al. (2007). "CK-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise". J. Appl. Physiol. 103 (2): 504–10. doi:10.1152/japplphysiol.00081.2007. PMID 17478608.
Kelley WE, Lockwood CM, Cervelli DR, et al. (2009). "Cardiovascular disease testing on the Dimension Vista system: biomarkers of acute coronary syndromes". Clin. Biochem. 42 (13–14): 1444–51. doi:10.1016/j.clinbiochem.2009.05.020. PMID 19523464.
Wang PF, Flynn AJ, Naor MM, et al. (2006). "Exploring the role of the active site cysteine in human muscle creatine kinase". Biochemistry. 45 (38): 11464–72. doi:10.1021/bi0607002. PMC 2556515. PMID 16981706.
Eeg-Olofsson O, Kalimo H, Eeg-Olofsson KE, et al. (2008). "Duchenne muscular dystrophy and idiopathic hyperCKemia in the same family". Eur. J. Paediatr. Neurol. 12 (5): 404–7. doi:10.1016/j.ejpn.2007.10.014. PMID 18833644.
Santiago C, Ruiz JR, Muniesa CA, et al. (2009). "Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing". Scand J Med Sci Sports. 20 (1): e188–e194. doi:10.1111/j.1600-0838.2009.00943.x. PMID 19422651.
Zhou DQ, Hu Y, Liu G, et al. (2006). "Muscle-specific creatine kinase gene polymorphism and running economy responses to an 18-week 5000-m training programme". Br J Sports Med. 40 (12): 988–91. doi:10.1136/bjsm.2006.029744. PMC 2577470. PMID 17000714.
Koyama S, Hata S, Witt CC, et al. (2008). "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis". J. Mol. Biol. 376 (5): 1224–36. doi:10.1016/j.jmb.2007.11.049. PMID 18222470.
Li S, Bai JH, Park YD, Zhou HM (2006). "Capture of monomeric refolding intermediate of human muscle creatine kinase". Protein Sci. 15 (1): 171–81. doi:10.1110/ps.051738406. PMC 2242377. PMID 16373479.
Kim HJ, Lee YH, Kim CK (2009). "Changes in serum cartilage oligomeric matrix protein (COMP), plasma CPK and plasma hs-CRP in relation to running distance in a marathon (42.195 km) and an ultra-marathon (200 km) race". Eur. J. Appl. Physiol. 105 (5): 765–70. doi:10.1007/s00421-008-0961-x. PMID 19125286.
Wallimann T, Hemmer W (1994). "Creatine kinase in non-muscle tissues and cells". Mol. Cell. Biochem. 133–134: 193–220. doi:10.1007/BF01267955. PMID 7808454.

Vanjski linkovi[uredi | uredi izvor]

Creatine Kinase, MM Form na US National Library of Medicine Medical Subject Headings (MeSH)
Lokacija ljudskog genoma CKM i stranica sa detaljima o genu CKM u UCSC Genome Browseru.
P06732

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104879 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030399 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6959139-5] Rosenberg UB, Kunz G, Frischauf A, Lehrach H, Mähr R, Eppenberger HM, Perriard JC (novembar 1982). "Molecular cloning and expression during myogenesis of sequences coding for M-creatine kinase". Proc. Natl. Acad. Sci. U.S.A. 79 (21): 6589–92. doi:10.1073/pnas.79.21.6589. PMC 347173. PMID 6959139.

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