CMTM7

CMTM7
Identifikatori
Aliasi	CMTM7
Vanjski ID-jevi	OMIM: 607890 MGI: 2447166 HomoloGene: 15882 GeneCards: CMTM7
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	32,483,067 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	114,610,924 bp
Ontologija gena
Molekularna funkcija	• cytokine activity;
Ćelijska komponenta	• membrana; • Vanćelijsko; • integral component of membrane;
Biološki proces	• Hemotaksija; • B-1a B cell differentiation; • regulation of signaling receptor activity; • GO:0072468 Transdukcija signala;
	Izvori:Amigo / QuickGO
Ortolozi
	112616
	102545
	ENSG00000153551
	ENSMUSG00000032436
	Q96FZ5
	Q9ESD6
	NM_138410; NM_181472
	NM_001252479; NM_133978
	NP_612419; NP_852137
	NP_001239408; NP_598739
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

CKLF-liki protein sa MARVEL transmembranskim domenom 7 jest protein koji je kod ljudi kodiran genom CMTM7 sa hromosoma 3.^[5]

Program Nacionalnog instituta za zdravlje sisara (MGC) predstavlja multiinstitucionalni napor da se identifikuje i sekvencira klon cDNK koji sadrži kompletan otvoreni okvir čitanja za svaki ljudske i mišje gene. EST-ovi su generirani iz biblioteka obogaćenih za cDNK pune dužine i analizirani da bi se identificirali kandidati za klonove punog ORF-a, koji su potom sekvencionirani do visoke preciznosti. MGC je do sada sekvencirao i verificirao puni ORF za neredundantni skup od >9.000 ljudskih i >6.000 mišjih gena. Identifikovani su i kandidati za klonove sa punim ORF za dodatnih 7.800 ljudskih i 3.500 mišjih gena. Sve MGC sekvence i klonovi dostupni su bez ograničenja kroz javne baze podataka i mreže za distribuciju klonova.^[6]

Funkcija[uredi | uredi izvor]

Ovaj gen pripada natporodici genskih faktora sličnih hemokinu, novoj porodici koja je slična hemokinima i porodici 4 transmembranih proteina. Ovaj gen je jedan od nekoliko gena faktora sličnih hemokinima koji se nalaze u klasteru na hromosomu 3. Djeluje kao supresor tumora koji regulira G/S tranziciju u ćelijskom ciklusu i signalizaciju receptora/proteina kinaza B epidermnog faktora rasta tokom patogeneze tumora. Alternativna prerada rezultira višestrukim varijantama transkripta koje kodiraju različite izoforme.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153551 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032436 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CKLF like MARVEL transmembrane domain containing 7". Pristupljeno 9. 3. 2016.
^ Robert L Strausberg , Elise A Feingold, Lynette H Grouse, Jeffery G Derge, Richard D Klausner, Francis S Collins, Lukas Wagner, Carolyn M Shenmen, Gregory D Schuler, Stephen F Altschul, Barry Zeeberg, Kenneth H Buetow, Carl F Schaefer, Narayan K Bhat, Ralph F Hopkins, Heather Jordan, Troy Moore, Steve I Max, Jun Wang, Florence Hsieh, Luda Diatchenko, Kate Marusina, Andrew A Farmer, Gerald M Rubin, Ling Hong, Mark Stapleton, M Bento Soares, Maria F Bonaldo, Tom L Casavant, Todd E Scheetz, Michael J Brownstein, Ted B Usdin, Shiraki Toshiyuki, Piero Carninci, Christa Prange, Sam S Raha, Naomi A Loquellano, Garrick J Peters, Rick D Abramson, Sara J Mullahy, Stephanie A Bosak, Paul J McEwan, Kevin J McKernan, Joel A Malek, Preethi H Gunaratne, Stephen Richards, Kim C Worley, Sarah Hale, Angela M Garcia, Laura J Gay, Stephen W Hulyk, Debbie K Villalon, Donna M Muzny, Erica J Sodergren, Xiuhua Lu, Richard A Gibbs, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez, Michelle Whiting, Anup Madan, Alice C Young, Yuriy Shevchenko, Gerard G Bouffard, Robert W Blakesley, Jeffrey W Touchman, Eric D Green, Mark C Dickson, Alex C Rodriguez, Jane Grimwood, Jeremy Schmutz, Richard M Myers, Yaron S N Butterfield, Martin I Krzywinski, Ursula Skalska, Duane E Smailus, Angelique Schnerch, Jacqueline E Schein, Steven J M Jones, Marco A Marra (2002): Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A 99(26):16899-903.

Dopunska literatura[uredi | uredi izvor]

Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153551 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032436 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CKLF like MARVEL transmembrane domain containing 7". Pristupljeno 9. 3. 2016.

[6] Robert L Strausberg , Elise A Feingold, Lynette H Grouse, Jeffery G Derge, Richard D Klausner, Francis S Collins, Lukas Wagner, Carolyn M Shenmen, Gregory D Schuler, Stephen F Altschul, Barry Zeeberg, Kenneth H Buetow, Carl F Schaefer, Narayan K Bhat, Ralph F Hopkins, Heather Jordan, Troy Moore, Steve I Max, Jun Wang, Florence Hsieh, Luda Diatchenko, Kate Marusina, Andrew A Farmer, Gerald M Rubin, Ling Hong, Mark Stapleton, M Bento Soares, Maria F Bonaldo, Tom L Casavant, Todd E Scheetz, Michael J Brownstein, Ted B Usdin, Shiraki Toshiyuki, Piero Carninci, Christa Prange, Sam S Raha, Naomi A Loquellano, Garrick J Peters, Rick D Abramson, Sara J Mullahy, Stephanie A Bosak, Paul J McEwan, Kevin J McKernan, Joel A Malek, Preethi H Gunaratne, Stephen Richards, Kim C Worley, Sarah Hale, Angela M Garcia, Laura J Gay, Stephen W Hulyk, Debbie K Villalon, Donna M Muzny, Erica J Sodergren, Xiuhua Lu, Richard A Gibbs, Jessica Fahey, Erin Helton, Mark Ketteman, Anuradha Madan, Stephanie Rodrigues, Amy Sanchez, Michelle Whiting, Anup Madan, Alice C Young, Yuriy Shevchenko, Gerard G Bouffard, Robert W Blakesley, Jeffrey W Touchman, Eric D Green, Mark C Dickson, Alex C Rodriguez, Jane Grimwood, Jeremy Schmutz, Richard M Myers, Yaron S N Butterfield, Martin I Krzywinski, Ursula Skalska, Duane E Smailus, Angelique Schnerch, Jacqueline E Schein, Steven J M Jones, Marco A Marra (2002): Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A 99(26):16899-903.

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