COL16A1

S Wikipedije, slobodne enciklopedije
COL16A1
Identifikatori
AliasiCOL16A1
Vanjski ID-jeviOMIM: 120326 MGI: 1095396 HomoloGene: 1397 GeneCards: COL16A1
Lokacija gena (čovjek)
Hromosom 1 (čovjek)
Hrom.Hromosom 1 (čovjek)[1]
Hromosom 1 (čovjek)
Genomska lokacija za COL16A1
Genomska lokacija za COL16A1
Bend1p35.2Početak31,652,263 bp[1]
Kraj31,704,319 bp[1]
Lokacija gena (miš)
Hromosom 4 (miš)
Hrom.Hromosom 4 (miš)[2]
Hromosom 4 (miš)
Genomska lokacija za COL16A1
Genomska lokacija za COL16A1
Bend4|4 D2.2Početak129,941,633 bp[2]
Kraj129,993,076 bp[2]
Obrazac RNK ekspresije




Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija integrin binding
GO:0001948, GO:0016582 protein binding
extracellular matrix structural constituent
extracellular matrix structural constituent conferring tensile strength
Ćelijska komponenta extracellular region
collagen type XVI trimer
collagen
endoplasmic reticulum lumen
GO:0005578 Vanćelijski matriks
Vanćelijsko
collagen-containing extracellular matrix
Biološki proces cellular response to amino acid stimulus
integrin-mediated signaling pathway
female pregnancy
positive regulation of focal adhesion assembly
integrin activation
Ćelijska adhezija
extracellular matrix organization
cell adhesion mediated by integrin
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001856

NM_028266

RefSeq (bjelančevina)

NP_001847

NP_082542
NP_001391281
NP_001391282

Lokacija (UCSC)Chr 1: 31.65 – 31.7 MbChr 4: 129.94 – 129.99 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Kolagenski alfa-1(XVI) lanac jest protein koji je kod ljudi kodiran genom COL16A1 sa hromosoma 1.[5][6]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.604 aminokiseline, a molekulska težina 157.751 Da.[7]

1020304050
MWVSWAPGLWLLGLWATFGHGANTGAQCPPSQQEGLKLEHSSSLPANVTG
FNLIHRLSLMKTSAIKKIRNPKGPLILRLGAAPVTQPTRRVFPRGLPEEF
ALVLTLLLKKHTHQKTWYLFQVTDANGYPQISLEVNSQERSLELRAQGQD
GDFVSCIFPVPQLFDLRWHKLMLSVAGRVASVHVDCSSASSQPLGPRRPM
RPVGHVFLGLDAEQGKPVSFDLQQVHIYCDPELVLEEGCCEILPAGCPPE
TSKARRDTQSNELIEINPQSEGKVYTRCFCLEEPQNSEVDAQLTGRISQK
AERGAKVHQETAADECPPCVHGARDSNVTLAPSGPKGGKGERGLPGPPGS
KGEKGARGNDCVRISPDAPLQCAEGPKGEKGESGALGPSGLPGSTGEKGQ
KGEKGDGGIKGVPGKPGRDGRPGEICVIGPKGQKGDPGFVGPEGLAGEPG
PPGLPGPPGIGLPGTPGDPGGPPGPKGDKGSSGIPGKEGPGGKPGKPGVK
GEKGDPCEVCPTLPEGFQNFVGLPGKPGPKGEPGDPVPARGDPGIQGIKG
EKGEPCLSCSSVVGAQHLVSSTGASGDVGSPGFGLPGLPGRAGVPGLKGE
KGNFGEAGPAGSPGPPGPVGPAGIKGAKGEPCEPCPALSNLQDGDVRVVA
LPGPSGEKGEPGPPGFGLPGKQGKAGERGLKGQKGDAGNPGDPGTPGTTG
RPGLSGEPGVQGPAGPKGEKGDGCTACPSLQGTVTDMAGRPGQPGPKGEQ
GPEGVGRPGKPGQPGLPGVQGPPGLKGVQGEPGPPGRGVQGPQGEPGAPG
LPGIQGLPGPRGPPGPTGEKGAQGSPGVKGATGPVGPPGASVSGPPGRDG
QQGQTGLRGTPGEKGPRGEKGEPGECSCPSQGDLIFSGMPGAPGLWMGSS
WQPGPQGPPGIPGPPGPPGVPGLQGVPGNNGLPGQPGLTAELGSLPIEQH
LLKSICGDCVQGQRAHPGYLVEKGEKGDQGIPGVPGLDNCAQCFLSLERP
RAEEARGDNSEGDPGCVGSPGLPGPPGLPGQRGEEGPPGMRGSPGPPGPI
GPPGFPGAVGSPGLPGLQGERGLTGLTGDKGEPGPPGQPGYPGATGPPGL
PGIKGERGYTGSAGEKGEPGPPGSEGLPGPPGPAGPRGERGPQGNSGEKG
DQGFQGQPGFPGPPGPPGFPGKVGSPGPPGPQAEKGSEGIRGPSGLPGSP
GPPGPPGIQGPAGLDGLDGKDGKPGLRGDPGPAGPPGLMGPPGFKGKTGH
PGLPGPKGDCGKPGPPGSTGRPGAEGEPGAMGPQGRPGPPGHVGPPGPPG
QPGPAGISAVGLKGDRGATGERGLAGLPGQPGPPGHPGPPGEPGTDGAAG
KEGPPGKQGFYGPPGPKGDPGAAGQKGQAGEKGRAGMPGGPGKSGSMGPV
GPPGPAGERGHPGAPGPSGSPGLPGVPGSMGDMVNYDEIKRFIRQEIIKM
FDERMAYYTSRMQFPMEMAAAPGRPGPPGKDGAPGRPGAPGSPGLPGQIG
REGRQGLPGVRGLPGTKGEKGDIGIGIAGENGLPGPPGPQGPPGYGKMGA
TGPMGQQGIPGIPGPPGPMGQPGKAGHCNPSDCFGAMPMEQQYPPMKTMK
GPFG

Funkcija[uredi | uredi izvor]

Ovaj gen kodira alfa lanac kolagena tipa XVI, člana porodice kolagena FACIT (kolageni povezani s fibrilima sa prekinutim spiralama). Članovi ove porodice kolagena u vezi su sa kolagenima koji formiraju vlakna, kao što su tip I i II, i služe za održavanje integriteta vanćelijskog matriksa. Visoki nivoi kolagena tipa XVI pronađeni su u fibroblastima i keratinocitima, te u glatkim mišićima i amnionu.[6]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000084636 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040690 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pan TC, Zhang RZ, Mattei MG, Timpl R, Chu ML (Aug 1992). "Cloning and chromosomal location of human alpha 1(XVI) collagen". Proc Natl Acad Sci U S A. 89 (14): 6565–9. Bibcode:1992PNAS...89.6565P. doi:10.1073/pnas.89.14.6565. PMC 49542. PMID 1631157.
  6. ^ a b "Entrez Gene: COL16A1 collagen, type XVI, alpha 1".
  7. ^ "UniProt, Q07092" (jezik: engleski). Pristupljeno 23. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]