CPLX2

CPLX2
Identifikatori
Aliasi	CPLX2
Vanjski ID-jevi	OMIM: 605033 MGI: 104726 HomoloGene: 38212 GeneCards: CPLX2
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	175,884,021 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	54,531,730 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• syntaxin-1 binding; • syntaxin binding; • SNARE binding; • calcium-dependent protein binding;
Ćelijska komponenta	• citoplazma; • citosol; • synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; • mast cell granule; • sinapsa; • synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex; • neuronal cell body; • dendrit; • SNARE complex; • presynapse; • calyx of Held; • postsynapse; • glutamatergic synapse; • terminal bouton;
Biološki proces	• Ćelijska diferencijacija; • synaptic vesicle exocytosis; • nervous system development; • positive regulation of synaptic plasticity; • vesicle docking involved in exocytosis; • regulation of exocytosis; • mast cell degranulation; • neurotransmitter transport; • Egzocitoza; • regulation of synaptic vesicle fusion to presynaptic active zone membrane; • regulation of neurotransmitter secretion;
	Izvori:Amigo / QuickGO
Ortolozi
	10814
	12890
	ENSG00000145920
	ENSMUSG00000025867
	Q6PUV4
	P84086
	NM_001008220; NM_006650; NM_032282
	NM_009946; NM_001362218
	NP_001008221; NP_006641
	NP_034076; NP_001349147
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kompleksin-2 jest protein koji je kod ljudi kodiran genom CPLX2.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 134 aminokiseline, а molekulska težina 15.394 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDFVMKQALG	GATKDMGKML	GGEEEKDPDA	QKKEEERQEA	LRQQEEERKA
KHARMEAERE	KVRQQIRDKY	GLKKKEEKEA	EEKAALEQPC	EGSLTRPKKA
IPAGCGDEEE	EEEESILDTV	LKYLPGPLQD	MFKK

Funkcija[uredi | uredi izvor]

Proteini kodirani genimaa porodice kompleksin/sinafin su citosolni proteini koji funkcioniraju u egzocitozi sinapsnih vezikula. Ovi proteini vežu sintaksin, dio SNAP receptora. Proteinski proizvod ovog gena veže se za kompleks receptora SNAP -a i ometa ga, omogućavajući oslobađanje predajnika. Za ovaj gen pronađene su dvije varijante transkripta koje kodiraju isti protein.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145920 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025867 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
^ Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.
^ ^a ^b "Entrez Gene: CPLX2 complexin 2".
^ "UniProt, Q6PUV4" (jezik: engleski). Pristupljeno 13. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Abe T (2002). "[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis]". Tanpakushitsu Kakusan Koso. 47 (7): 794–800. PMID 12058476.
Christensen VL, Johnston NP (1978). "Effect of time of day of insemination and the position of the egg in the oviduct on the fertility of turkeys". Poult. Sci. 56 (2): 458–62. doi:10.3382/ps.0560458. PMID 605033.
Morgans CW, Brandstätter JH, Kellerman J, et al. (1996). "A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina". J. Neurosci. 16 (21): 6713–21. doi:10.1523/JNEUROSCI.16-21-06713.1996. PMC 6579260. PMID 8824312.
Harrison PJ, Eastwood SL (1998). "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia". Lancet. 352 (9141): 1669–73. doi:10.1016/S0140-6736(98)03341-8. PMID 9853440. S2CID 45239545.
Ishizuka T, Saisu H, Odani S, et al. (1999). "Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex". Neuroscience. 88 (1): 295–306. doi:10.1016/S0306-4522(98)00223-1. PMID 10051208. S2CID 46636775.
Yamada M, Saisu H, Ishizuka T, et al. (1999). "Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types". Neuroscience. 93 (1): 7–18. doi:10.1016/S0306-4522(99)00104-9. PMID 10430466. S2CID 21532356.
Pabst S, Hazzard JW, Antonin W, et al. (2000). "Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions". J. Biol. Chem. 275 (26): 19808–18. doi:10.1074/jbc.M002571200. PMID 10777504.
Eastwood SL, Cotter D, Harrison PJ (2001). "Cerebellar synaptic protein expression in schizophrenia". Neuroscience. 105 (1): 219–29. doi:10.1016/S0306-4522(01)00141-5. PMID 11483314. S2CID 34257327.
Eastwood SL, Harrison PJ (2001). "Synaptic pathology in the anterior cingulate cortex in schizophrenia and mood disorders. A review and a Western blot study of synaptophysin, GAP-43 and the complexins". Brain Res. Bull. 55 (5): 569–78. doi:10.1016/S0361-9230(01)00530-5. PMID 11576753. S2CID 23012653.
Pabst S, Margittai M, Vainius D, et al. (2002). "Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis". J. Biol. Chem. 277 (10): 7838–48. doi:10.1074/jbc.M109507200. PMID 11751907.
Sawada K, Young CE, Barr AM, et al. (2002). "Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness". Mol. Psychiatry. 7 (5): 484–92. doi:10.1038/sj.mp.4000978. PMID 12082566.
Hu K, Carroll J, Rickman C, Davletov B (2003). "Action of complexin on SNARE complex". J. Biol. Chem. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Edwardson JM, Wang CT, Gong B, et al. (2003). "Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II". J. Biol. Chem. 278 (33): 30849–53. doi:10.1074/jbc.M304615200. PMID 12807877.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophr. Res. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
DiProspero NA, Chen EY, Charles V, et al. (2005). "Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements". J. Neurocytol. 33 (5): 517–33. doi:10.1007/s11068-004-0514-8. PMID 15906159. S2CID 20082165.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CPLX2 i stranica sa detaljima o genu CPLX2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145920 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025867 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7553862-5] McMahon HT, Missler M, Li C, Sudhof TC (Nov 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.

[pmid16162394-6] Raevskaya NM, Dergunova LV, Vladychenskaya IP, Stavchansky VV, Oborina MV, Poltaraus AB, Limborska SA (Sep 2005). "Structural organization of the human complexin 2 gene (CPLX2) and aspects of its functional activity". Gene. 359: 127–37. doi:10.1016/j.gene.2005.07.005. PMID 16162394.

[entrez-7] "Entrez Gene: CPLX2 complexin 2".

[UniProt-8] "UniProt, Q6PUV4" (jezik: engleski). Pristupljeno 13. 10. 2021.

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