CRELD2

CRELD2
Identifikatori
Aliasi	CRELD2
Vanjski ID-jevi	OMIM: 607171 MGI: 1923987 HomoloGene: 11526 GeneCards: CRELD2
Lokacija gena (čovjek)
Hrom.	Hromosom 22 (čovjek)
Kraj	49,927,540 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	88,710,886 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	79174
	76737
	ENSG00000184164
	ENSMUSG00000023272
	Q6UXH1
	Q9CYA0
	NM_001135101; NM_001284317; NM_001284318; NM_024324
	NM_029720
	NP_001128573; NP_001271246; NP_001271247; NP_077300
	NP_083996
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cisteinom-bogati protein 2 sa EGF-likim domenom jest protein koji je kod ljudi kodiran genom CRELD2 sa hromosoma 22.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 353 aminokiseline, a molekulska težina 38.192 Da.

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MRLPRRAALG	LLPLLLLLPP	APEAAKKPTP	CHRCRGLVDK	FNQGMVDTAK
KNFGGGNTAW	EEKTLSKYES	SEIRLLEILE	GLCESSDFEC	NQMLEAQEEH
LEAWWLQLKS	EYPDLFEWFC	VKTLKVCCSP	GTYGPDCLAC	QGGSQRPCSG
NGHCSGDGSR	QGDGSCRCHM	GYQGPLCTDC	MDGYFSSLRN	ETHSICTACD
ESCKTCSGLT	NRDCGECEVG	WVLDEGACVD	VDECAAEPPP	CSAAQFCKNA
NGSYTCEECD	SSCVGCTGEG	PGNCKECISG	YAREHGQCAD	VDECSLAEKT
CVRKNENCYN	TPGSYVCVCP	DGFEETEDAC	VPPAEAEATE	GESPTQLPSR
EDL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184164 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023272 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL (Jul 2002). "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins". Gene. 293 (1–2): 47–57. doi:10.1016/S0378-1119(02)00696-0. PMID 12137942.
^ "Entrez Gene: CRELD2 cysteine-rich with EGF-like domains 2".

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ortiz JA, Castillo M, del Toro ED, et al. (2006). "The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits". J. Neurochem. 95 (6): 1585–96. doi:10.1111/j.1471-4159.2005.03473.x. PMID 16238698.
Maslen CL, Babcock D, Redig JK, et al. (2007). "CRELD2: gene mapping, alternate splicing, and comparative genomic identification of the promoter region". Gene. 382: 111–20. doi:10.1016/j.gene.2006.06.016. PMID 16919896.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CRELD2 i stranica sa detaljima o genu CRELD2 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184164 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023272 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12137942-5] Rupp PA, Fouad GT, Egelston CA, Reifsteck CA, Olson SB, Knosp WM, Glanville RW, Thornburg KL, Robinson SW, Maslen CL (Jul 2002). "Identification, genomic organization and mRNA expression of CRELD1, the founding member of a unique family of matricellular proteins". Gene. 293 (1–2): 47–57. doi:10.1016/S0378-1119(02)00696-0. PMID 12137942.

[entrez-6] "Entrez Gene: CRELD2 cysteine-rich with EGF-like domains 2".

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