S Wikipedije, slobodne enciklopedije
Oksidoreduktazoliki kinonski protein 1enzim koji je kod ljudi kodiran genom CRYZL1 sa hromosoma 21 .[5] [6]
Dužina polipeptidnog lanca je 349 aminokiselina , a molekulska težina 38.697 Da .[6]
10 20 30 40 50 MKGLYFQQSS TDEEITFVFQ EKEDLPVTED NFVKLQVKAC ALSQINTKLL AEMKMKKDLF PVGREIAGIV LDVGSKVSFF QPDDEVVGIL PLDSEDPGLC EVVRVHEHYL VHKPEKVTWT EAAGSIRDGV RAYTALHYLS HLSPGKSVLI MDGASAFGTI AIQLAHHRGA KVISTACSLE DKQCLERFRP PIARVIDVSN GKVHVAESCL EETGGLGVDI VLDAGVRLYS KDDEPAVKLQ LLPHKHDIIT LLGVGGHWVT TEENLQLDPP DSHCLFLKGA TLAFLNDEVW NLSNVQQGKY LCILKDVMEK LSTGVFRPQL DEPIPLYEAK VSMEAVQKNQ GRKKQVVQF
Ovaj gen kodira protein koji ima sličnu sekvencu sa zeta kristalinom , također poznatim kao kinon-oksidoreduktaza . Ovaj protein sličan zeta kristalinu takođe sadrži NAD(P)H mjesto vezivanja . Uočene su alternativno prerađene varijante transkripta , ali priroda njihove pune dužine nije u potpunosti utvrđena.[6]
^ a b c GRCh38: Ensembl release 89: ENSG00000205758 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058240 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kim MY, Lee HK, Park JS, Park SH, Kwon HB, Soh J (Jun 1999). "Identification of a zeta-crystallin (quinone reductase)-like 1 gene (CRYZL1) mapped to human chromosome 21q22.1". Genomics . 57 (1): 156–9. doi :10.1006/geno.1998.5714 . PMID 10191096 . ^ a b c "Entrez Gene: CRYZL1 crystallin, zeta (quinone reductase)-like 1" .
Mount SM (2000). "Genomic Sequence, Splicing, and Gene Annotation" . Am. J. Hum. Genet . 67 (4): 788–92. doi :10.1086/303098 . PMC 1287883 PMID 10986039 . Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9. Bibcode :2000Natur.405..311H . doi :10.1038/35012518 PMID 10830953 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins" . BMC Genomics . 7 : 155. doi :10.1186/1471-2164-7-155 . PMC 1526728 PMID 16780588 . Fernández MR, Porté S, Crosas E, et al. (2007). "Human and yeast zeta-crystallins bind AU-rich elements in RNA" . Cell. Mol. Life Sci . 64 (11): 1419–27. doi :10.1007/s00018-007-7091-1 . PMID 17497241 . S2CID 2165411 .
