S Wikipedije, slobodne enciklopedije
Cisteinom i glicinom -bogati protein 1protein koji je kod ljudi kodiran genom CSRP1 sa hromosoma 1 .[5] [6] [7]
Dužina polipeptidnog lanca je 193 aminokiseline , a molekulska težina 20.567 Da .[8]
10 20 30 40 50 MPNWGGGKKC GVCQKTVYFA EEVQCEGNSF HKSCFLCMVC KKNLDSTTVA VHGEEIYCKS CYGKKYGPKG YGYGQGAGTL STDKGESLGI KHEEAPGHRP TTNPNASKFA QKIGGSERCP RCSQAVYAAE KVIGAGKSWH KACFRCAKCG KGLESTTLAD KDGEIYCKGC YAKNFGPKGF GFGQGAGALV HSE
CSRP1 je član CSRP porodice gena koji kodiraju grupu LIM-domenskih proteina, koji mogu biti uključeni u regulatorne procese važne za razvoj i ćelijsku diferencijaciju . LIM/dvostruki motiv cinkovog prsta koji se nalazi u CRP1 nalazi se u grupi proteina s kritičnim funkcijama u regulaciji gena , rastu ćelija i somatskim diferencijacijama. Ostali geni u porodici uključuju CSRP2 i CSRP3 .[7]
^ a b c GRCh38: Ensembl release 89: ENSG00000159176 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026421 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif" . Nucleic Acids Res . 18 (13): 3871–9. doi :10.1093/nar/18.13.3871 . PMC 331088 PMID 2115670 . ^ Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet . 83 (1–2): 10–1. doi :10.1159/000015152 . PMID 9925910 . S2CID 28018584 . ^ a b "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1" .^ "UniProt, P21291" (jezik: en.). Pristupljeno 9. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
Weiskirchen R, Günther K (2003). "The CRP/MLP/TLP family of LIM domain proteins: acting by connecting". BioEssays . 25 (2): 152–62. doi :10.1002/bies.10226 . PMID 12539241 . S2CID 21364125 . Wang X, Lee G, Liebhaber SA, Cooke NE (1992). "Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc" . J. Biol. Chem . 267 (13): 9176–84. doi :10.1016/S0021-9258(19)50405-7 PMID 1374386 . Wang X, Ray K, Szpirer J, et al. (1992). "Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism". Genomics . 14 (2): 391–7. doi :10.1016/S0888-7543(05)80231-9 . PMID 1385304 . Feuerstein R, Wang X, Song D, et al. (1994). "The LIM/double zinc-finger motif functions as a protein dimerization domain" . Proc. Natl. Acad. Sci. U.S.A . 91 (22): 10655–9. Bibcode :1994PNAS...9110655F . doi :10.1073/pnas.91.22.10655 PMC 45080 PMID 7938009 . Dubé JY, Chapdelaine P, Trahan PL, et al. (1998). "Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate" . Arch. Androl . 40 (2): 109–15. doi :10.3109/01485019808987933 PMID 9507743 . Harper BD, Beckerle MC, Pomiès P (2001). "Fine mapping of the alpha-actinin binding site within cysteine-rich protein" . Biochem. J . 350 Pt 1 (Pt 1): 269–74. doi :10.1042/0264-6021:3500269 . PMC 1221251 PMID 10926853 . Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1–11. doi :10.1016/S0960-9822(01)00650-9 PMID 11790298 . S2CID 14132033 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization" . Nat. Biotechnol . 24 (10): 1285–92. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Hirasawa Y, Arai M, Imazeki F, et al. (2007). "Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma". Oncology . 71 (1–2): 77–85. doi :10.1159/000100475 . PMID 17341888 . S2CID 40174270 . Wang Q, Williamson M, Bott S, et al. (2007). "Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer" . Oncogene . 26 (45): 6560–5. doi :10.1038/sj.onc.1210472 PMID 17486081 .
