CSTL1

CSTL1
Identifikatori
Aliasi	CSTL1
Vanjski ID-jevi	MGI: 2652834 HomoloGene: 16283 GeneCards: CSTL1
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek) Bend 20p11.21 Početak 23,439,685 bp Kraj 23,444,930 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2|2 G3 Početak 148,592,278 bp Kraj 148,597,353 bp
Ontologija gena Molekularna funkcija • peptidase inhibitor activity • protease binding • cysteine-type endopeptidase inhibitor activity Ćelijska komponenta • extracellular region • Vanćelijsko Biološki proces • negative regulation of peptidase activity • negative regulation of cysteine-type endopeptidase activity • negative regulation of endopeptidase activity Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	128817	228756
Ensembl	ENSG00000125823	ENSMUSG00000055177
UniProt	Q9H114	Q80Y72
RefSeq (mRNK)	NM_138283	NM_177655 NM_001362207
RefSeq (bjelančevina)	NP_612140	NP_808323 NP_001349136
Lokacija (UCSC)	Chr 20: 23.44 – 23.44 Mb	Chr 2: 148.59 – 148.6 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Cistatinoliki protein 1 je protein koji je kod ljudi kodiran genom CSTL1. .

Superporodica cistatina obuhvata proteine koji sadrže višestruke sekvence slične cistatinu. Neki od članova su aktivni inhibitori cistein proteaza, dok su drugi izgubili ili možda nikada nisu stekli ovu inhibitornu aktivnost. U natporodici postoje tri porodice inhibitora, uključujući tip 1 cistatina (stefini), cistatini tipa 2 i kininogeni. Proteini cistatina tipa 2 su klasa inhibitora cistein-proteinaze koji se nalaze u raznim ljudskim tečnostima i sekretu. Lokus cistatina na hromosomu 20 sadrži većinu gena za cistatin tipa 2 i pseudogene. Ovaj gen nalazi se na telomernom kraju cistatinskog lokusa i kodira protein sličan cistatinu tipa 2. Specifična funkcija ovog proteina nije utvrđena.

Vanjski linkovi

• Lokacija ljudskog genoma CSTL1 i stranica sa detaljima o genu CSTL1 u UCSC Genome Browseru.

Dopunska literatura

• Brown WM, Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. 6 (1): 5–12. doi:10.1002/pro.5560060102. PMC 2143511. PMID 9007972.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Thiesse M, Millar SJ, Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. 13 (2): 97–116. doi:10.1089/dna.1994.13.97. PMID 8179826.
• Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. 24 (1): 172–5. doi:10.1006/geno.1994.1595. PMID 7896273.
• Dickinson DP, Thiesse M, Dempsey LD, Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. 4 (3–4): 573–80. doi:10.1177/10454411930040034401. PMID 7690606.
• Saitoh E, Isemura S, Sanada K, et al. (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID 3202964.