CTCFL

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CTCFL
Identifikatori
AliasiCTCFL
Vanjski ID-jeviOMIM: 607022 MGI: 3652571 HomoloGene: 46476 GeneCards: CTCFL
Lokacija gena (čovjek)
Hromosom 20 (čovjek)
Hrom.Hromosom 20 (čovjek)[1]
Hromosom 20 (čovjek)
Genomska lokacija za CTCFL
Genomska lokacija za CTCFL
Bend20q13.31Početak57,495,966 bp[1]
Kraj57,525,652 bp[1]
Lokacija gena (miš)
Hromosom 2 (miš)
Hrom.Hromosom 2 (miš)[2]
Hromosom 2 (miš)
Genomska lokacija za CTCFL
Genomska lokacija za CTCFL
Bend2|2 H3Početak173,093,609 bp[2]
Kraj173,119,525 bp[2]
Ontologija gena
Molekularna funkcija DNA binding
sequence-specific DNA binding
histone binding
GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
metal ion binding
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001948 protein binding
nucleic acid binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Ćelijska komponenta Jedro
citoplazma
Biološki proces regulation of gene expression by genetic imprinting
regulation of transcription, DNA-templated
regulation of histone H3-K4 methylation
DNA methylation involved in gamete generation
transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of gene expression
Ćelijski ciklus
histone methylation
positive regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
chromatin organization
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)
NM_001269040
NM_001269041
NM_001269042
NM_001269043
NM_001269044

NM_001269045
NM_001269046
NM_001269047
NM_001269048
NM_001269049
NM_001269050
NM_001269051
NM_001269052
NM_001269054
NM_001269055
NM_080618
NM_001386993
NM_001386994
NM_001386995
NM_001386996
NM_001386997

NM_001081387
NM_001355185

RefSeq (bjelančevina)
NP_001255969
NP_001255970
NP_001255971
NP_001255972
NP_001255973

NP_001255974
NP_001255975
NP_001255976
NP_001255977
NP_001255978
NP_001255979
NP_001255980
NP_001255981
NP_001255983
NP_001255984
NP_542185

NP_001074856
NP_001342114

Lokacija (UCSC)Chr 20: 57.5 – 57.53 MbChr 2: 173.09 – 173.12 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Transkripcijski represor CTCFL, znan i kao BORIS (brat regulatora imprintiranih mjesta) je protein koji je kod ljudi kodiran genom CTCFL.[5]

Funkcija[uredi | uredi izvor]

CCCTC-vezujući faktor (CTCF), faktor 11–cinkovog prsta uključen u regulaciju gena, koristi različite cinkove prste da veže različita ciljna mjesta DNK. CTCF formira izolatore osjetljive na metilaciju, koji reguliraju Inaktivaciju X-hromosoma. Transkripcijski potiskivač CTCFL (ovaj protein) je paralog CTCF-a i čini se da se prvenstveno eksprimira u citoplazmi spermatocit a, za razliku od CTCF-a, koji se primarno ispoljava u jedru somatskih ćelija. CTCF i CTCFL obično se izražavaju u međusobno isključivom obrascu, koji korelira sa resetiranjem oznaka metilacije tokom diferencijacije muških klicinih ćelija.[5]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124092 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070495 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: CTCFL CCCTC-binding factor (zinc finger protein)-like".

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]