CXCL2

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski ligand 2
Hemokinski ligand 2
Identifikatori
Simbol	CXCL2
Alt. simboli	SCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a
NCBI gen	2920
HGNC	4603
OMIM	139110
RefSeq	NM_002089
UniProt	P19875
Ostali podaci
Lokus	Hrom. 4 q21
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CXCL2
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1QNK
Identifikatori
Aliasi	CXCL2
Vanjski ID-jevi	OMIM: 139110 MGI: 108068 HomoloGene: 105490 GeneCards: CXCL2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	74,099,196 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	91,040,974 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • CXCR chemokine receptor binding; • cytokine activity; • chemokine activity;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• chemokine-mediated signaling pathway; • response to molecule of bacterial origin; • response to lipopolysaccharide; • Hemotaksija; • positive regulation of neutrophil chemotaxis; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • regulation of cell population proliferation; • cell chemotaxis; • defense response; • inflammatory response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • neutrophil chemotaxis; • leukocyte chemotaxis; • cellular response to lipopolysaccharide;
	Izvori:Amigo / QuickGO
Ortolozi
	2920
	14825
	ENSG00000081041
	ENSMUSG00000029380
	P19875
	P12850
	NM_002089
	NM_008176
	NP_002080
	NP_032202
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski ligand 2 (X-C motiv) jest mali citokin koji je kod ljudi kodiran genom CXCL2 sa hromosoma 4. Pripada porodici CXC hemokina koja se također naziva makrofagni inflamatorni protein 2-alfa (MIP2-alfa), protein beta reguliran rastom (Gro-beta) i Gro onkogen- 2 (Gro-2). CXCL2 je 90% identičan u sekvenci aminokiselina kao srodni hemokin, CXCL1.

Ovaj hemokin luče monociti i makrofagi i ima hemotaksije za polimorfojedarne leukocite i hematopoetske matične ćelijee.^[5]^[6]^[7] Na hromosomu 4, gen za CXCL2 nalazi se u grupi drugih CXC hemokina.^[8] CXCL2 mobilizira ćelije, interakcijom sa ćelijskom površinom preko hemokinskog receptora koja se naziva hemokinski receptori (CXCR1 i CXCR2.^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 107 aminokiselina, а molekulska težina 11.389 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MARATLSAAP	SNPRLLRVAL	LLLLLVAASR	RAAGAPLATE	LRCQCLQTLQ
GIHLKNIQSV	KVKSPGPHCA	QTEVIATLKN	GQKACLNPAS	PMVKKIIEKM
LKNGKSN

Funkcija[uredi | uredi izvor]

CXCL2, kao i srodni hemokini, također je moćan hemoatraktant neutrofila i uključen je u mnoge imunske odgovore, uključujući zacjeljivanje rana, metastaze raka i angiogenezu.^[10] Studija je objavljena 2013. testirajući ulogu CXCL2, CXCL3 i CXCL1 u migraciji glatkih mišićnih ćelija disajnih puteva (ASMC), što ima značajnu ulogu u astmi. Rezultati ove studije pokazali su da i CXCL2 i CXCL3 pomažu u posredovanju migracije normalnnih i astmarskih ASMC-a kroz različite mehanizme.^[10]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081041 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029380 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (januar 1989). "Identification and characterization of macrophage inflammatory protein 2". Proceedings of the National Academy of Sciences of the United States of America. 86 (2): 612–6. Bibcode:1989PNAS...86..612W. doi:10.1073/pnas.86.2.612. PMC 286522. PMID 2643119.
^ Iida N, Grotendorst GR (oktobar 1990). "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue". Molecular and Cellular Biology. 10 (10): 5596–9. doi:10.1128/mcb.10.10.5596. PMC 361282. PMID 2078213.
^ ^a ^b Pelus LM, Fukuda S (august 2006). "Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties". Experimental Hematology. 34 (8): 1010–20. doi:10.1016/j.exphem.2006.04.004. PMID 16863907.
^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.
^ "UniProt, P19875" (jezik: engleski). Pristupljeno 23. 10. 2021.
^ ^a ^b Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q (septembar 2013). "Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration". Journal of Immunology. 191 (5): 2731–41. doi:10.4049/jimmunol.1203421. PMC 3748335. PMID 23904157.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000081041 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029380 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2643119-5] Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (januar 1989). "Identification and characterization of macrophage inflammatory protein 2". Proceedings of the National Academy of Sciences of the United States of America. 86 (2): 612–6. Bibcode:1989PNAS...86..612W. doi:10.1073/pnas.86.2.612. PMC 286522. PMID 2643119.

[pmid2078213-6] Iida N, Grotendorst GR (oktobar 1990). "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue". Molecular and Cellular Biology. 10 (10): 5596–9. doi:10.1128/mcb.10.10.5596. PMC 361282. PMID 2078213.

[pelus-7] Pelus LM, Fukuda S (august 2006). "Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties". Experimental Hematology. 34 (8): 1010–20. doi:10.1016/j.exphem.2006.04.004. PMID 16863907.

[pmid10343098-8] O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

[UniProt-9] "UniProt, P19875" (jezik: engleski). Pristupljeno 23. 10. 2021.

[Al-Alwan_2017-10] Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q (septembar 2013). "Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration". Journal of Immunology. 191 (5): 2731–41. doi:10.4049/jimmunol.1203421. PMC 3748335. PMID 23904157.

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