CXCL6

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski ligand 6 (C-X-C motiv)
(granulocitni hemotaksijski protein 2)
Hemokinski ligand 6 (C-X-C motiv); (granulocitni hemotaksijski protein 2)
Identifikatori
Simbol	CXCL6
Alt. simboli	SCYB6, GCP-2, CKA-3
NCBI gen	6372
HGNC	10643
OMIM	138965
RefSeq	NM_002993
UniProt	P80162
Ostali podaci
Lokus	Hrom. 4 q21
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CXCL6
Identifikatori
Aliasi	CXCL6
Vanjski ID-jevi	OMIM: 138965 MGI: 1096868 HomoloGene: 88671 GeneCards: CXCL6
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	73,849,064 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	90,909,483 bp
Ontologija gena
Molekularna funkcija	• cytokine activity; • CXCR chemokine receptor binding; • heparin binding; • chemokine activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• Hemotaksija; • cell-cell signaling; • chemokine-mediated signaling pathway; • regulation of cell population proliferation; • defense response to bacterium; • GO:0072468 Transdukcija signala; • neutrophil mediated immunity; • defense response; • positive regulation of neutrophil chemotaxis; • neutrophil chemotaxis; • neutrophil activation; • antimicrobial humoral immune response mediated by antimicrobial peptide; • cellular response to lipopolysaccharide; • inflammatory response; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • leukocyte homeostasis; • leukocyte chemotaxis; • response to lipopolysaccharide; • regulation of chemokine production; • regulation of neutrophil mediated killing of gram-negative bacterium;
	Izvori:Amigo / QuickGO
Ortolozi
	6372
	20311
	ENSG00000124875
	ENSMUSG00000029371
	P80162
	P50228
	NM_002993
	NM_009141
	NP_002984
	NP_033167
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski ligand 6 (C-X-C motiv) jest mali citokin koji je kod ljudi kodiran genom CXCL6 sa hromosoma 4. Pripada porodici hemokina CXC koja je poznata i kao granulocitni hemotaksijski protein 2 (GCP-2). Kao što mu prijašnji naziv govori, CXCL6 je hemoatraktant za neutrofilne granulocite.^[5]^[6] Izaziva hemotaksijske efekte interakcijom sa CXCR1 CXCR1 i CXCR2.^[6] Na ljudskom hromosomu 4 gen za CXCL6 nalazi se u grupi sa drugim CXC hemokinskim genima.^[7]^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124875 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.
^ ^a ^b Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.
^ Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.
^ O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124875 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.

[wuyts-6] Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.

[7] Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.

[8] O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

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