DDX39

DDX39
Identifikatori
Aliasi	DDX39A
Vanjski ID-jevi	MGI: 1915528 HomoloGene: 68487 GeneCards: DDX39A
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	14,419,383 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	84,453,521 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0008026 helicase activity; • nucleotide binding; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • hydrolase activity; • ATP binding; • ATPase activity; • vezivanje identičnih proteina; • vezivanje sa RNK;
Ćelijska komponenta	• membrana; • spliceosomal complex; • citoplazma; • jedro; • nukleoplazma; • nuclear speck; • Jedarce;
Biološki proces	• Prerada RNK; • mRNA splicing, via spliceosome; • mRNA processing; • mRNA export from nucleus; • cellular response to DNA damage stimulus; • RNA secondary structure unwinding; • Regulacija ekspresije gena; • RNA export from nucleus; • termination of RNA polymerase II transcription; • mRNA 3'-end processing;
	Izvori:Amigo / QuickGO
Ortolozi
	10212
	68278
	ENSG00000123136
	ENSMUSG00000005481
	O00148
	Q8VDW0
	NM_001204057; NM_005804; NM_138998
	NM_197982; NM_001363116; NM_001363117
	NP_005795
	NP_932099; NP_001350045; NP_001350046
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

ATP-ovisna RNK helikaza DDX39 je enzim koji je kod ljudi kodiran genom DDX39.^[5]^[6]

Ovaj gen kodira člana porodice DEAD boksa proteina. Ovi proteini su karakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD) i predstavljaju pretpostavljenu RNK helikazu. Uključeni u brojne ćelijske procese koji obuhvataju izmjenu sekundarne strukture RNK, kao što su inicijacija translacije, prerada jedarnog i mitohondrijskog transkripta i ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi porodice proteinskih boksova DEAD uključeni u embriogenezu, spermatogenezu, rast i diobu ćelija.^[6]

Aminokiselinsla sekvenca

10	20	30	40	50
MAEQDVENDL	LDYDEEEEPQ	APQESTPAPP	KKDIKGSYVS	IHSSGFRDFL
LKPELLRAIV	DCGFEHPSEV	QHECIPQAIL	GMDVLCQAKS	GMGKTAVFVL
ATLQQIEPVN	GQVTVLVMCH	TRELAFQISK	EYERFSKYMP	SVKVSVFFGG
LSIKKDEEVL	KKNCPHVVVG	TPGRILALVR	NRSFSLKNVK	HFVLDECDKM
LEQLDMRRDV	QEIFRLTPHE	KQCMMFSATL	SKDIRPVCRK	FMQDPMEVFV
DDETKLTLHG	LQQYYVKLKD	SEKNRKLFDL	LDVLEFNQVI	IFVKSVQRCM
ALAQLLVEQN	FPAIAIHRGM	AQEERLSRYQ	QFKDFQRRIL	VATNLFGRGM
DIERVNIVFN	YDMPEDSDTY	LHRVARAGRF	GTKGLAITFV	SDENDAKILN
DVQDRFEVNV	AELPEEIDIS	TYIEQSR

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123136 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005481 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics. 26 (2): 210–8. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.
^ ^a ^b "Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39".

Dopunska literatura[uredi | uredi izvor]

Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Strässer K, Masuda S, Mason P, et al. (2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Pryor A, Tung L, Yang Z, et al. (2004). "Growth-regulated expression and G0-specific turnover of the mRNA that encodes URH49, a mammalian DExH/D box protein that is highly related to the mRNA export protein UAP56". Nucleic Acids Res. 32 (6): 1857–65. doi:10.1093/nar/gkh347. PMC 390356. PMID 15047853.
Leaw CL, Ren EC, Choong ML (2004). "Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function". Cell. Mol. Life Sci. 61 (17): 2264–73. doi:10.1007/s00018-004-4205-x. PMID 15338056. S2CID 19729441.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kapadia F, Pryor A, Chang TH, Johnson LF (2007). "Nuclear localization of poly(A)+ mRNA following siRNA reduction of expression of the mammalian RNA helicases UAP56 and URH49". Gene. 384: 37–44. doi:10.1016/j.gene.2006.07.010. PMID 16949217.
Sugiura T, Sakurai K, Nagano Y (2007). "Intracellular characterization of DDX39, a novel growth-associated RNA helicase". Exp. Cell Res. 313 (4): 782–90. doi:10.1016/j.yexcr.2006.11.014. PMID 17196963.
Quaresma AJ, Sievert R, Nickerson JA (2013). "Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway". Mol. Biol. Cell. 24 (8): 1208–21. doi:10.1091/mbc.E12-06-0450. PMC 3623641. PMID 23427269.

Vanjski linkovi[uredi | uredi izvor]

DDX39A lokacija ljudskog genoma UCSC Genome Browser.

DDX39A detalji ljudskog genoma u UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123136 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005481 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601445-5] Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics. 26 (2): 210–8. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.

[entrez-6] "Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39".

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