DDX47
Vjerovatno ATP-ovisna RNK-helikaza DDX47 jest enzim koji je kod ljudi kodiran genom DDX47.[5]
Ovaj gen kodira člana proteinske porodice DEAD-boks. Proteini iz kutije DEAD, okarakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD), pretpostavljene su RNK-helikaze. Uključeni su u brojne ćelijske procese, koji uključuju promjenu sekundarne strukture RNK, kao što je iniciranje translacije, jedarne i mitohondrijske prerade i sklapanja ribosoma i splajsosoma. Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice uključeni u embriogenezu, spermatogenezu i ćelijski rast i diobu. Protein kodiran ovim genom može se kretati između jedra i citoplazme, te ima aktivnost ATPaza neovisnih o RNK. Za ovaj gen su pronađene dvije alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[5]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 455 aminokiselina, a molekulska težina 50.647 Da.[6]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAAPEEHDSP | TEASQPIVEE | EETKTFKDLG | VTDVLCEACD | QLGWTKPTKI | ||||
| QIEAIPLALQ | GRDIIGLAET | GSGKTGAFAL | PILNALLETP | QRLFALVLTP | ||||
| TRELAFQISE | QFEALGSSIG | VQSAVIVGGI | DSMSQSLALA | KKPHIIIATP | ||||
| GRLIDHLENT | KGFNLRALKY | LVMDEADRIL | NMDFETEVDK | ILKVIPRDRK | ||||
| TFLFSATMTK | KVQKLQRAAL | KNPVKCAVSS | KYQTVEKLQQ | YYIFIPSKFK | ||||
| DTYLVYILNE | LAGNSFMIFC | STCNNTQRTA | LLLRNLGFTA | IPLHGQMSQS | ||||
| KRLGSLNKFK | AKARSILLAT | DVASRGLDIP | HVDVVVNFDI | PTHSKDYIHR | ||||
| VGRTARAGRS | GKAITFVTQY | DVELFQRIEH | LIGKKLPGFP | TQDDEVMMLT | ||||
| ERVAEAQRFA | RMELREHGEK | KKRSREDAGD | NDDTEGAIGV | RNKVAGGKMK | ||||
| KRKGR |
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213782 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030204 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47".
- ^ "UniProt, Q9H0S4". Pristupljeno 8. 8. 2021.
Dopunska literatura[uredi | uredi izvor]
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