DDX52
| DDX52 | |||||||||||||||||||||||||
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| Identifikatori | |||||||||||||||||||||||||
| Aliasi | DDX52 | ||||||||||||||||||||||||
| Vanjski ID-jevi | OMIM: 612500 MGI: 1925644 HomoloGene: 5093 GeneCards: DDX52 | ||||||||||||||||||||||||
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| Ortolozi | |||||||||||||||||||||||||
| Vrste | Čovjek | Miš | |||||||||||||||||||||||
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| RefSeq (mRNK) | |||||||||||||||||||||||||
| RefSeq (bjelančevina) | |||||||||||||||||||||||||
| Lokacija (UCSC) | Chr 17: 37.61 – 37.64 Mb | Chr 11: 83.83 – 83.85 Mb | |||||||||||||||||||||||
| PubMed pretraga | [3] | [4] | |||||||||||||||||||||||
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Vjerovatna ATP-ovisna RNK-helikaza DDX52 je enzim koji je kod ljudi kodiran genom DDX52.[5][6]
Pretragom EST baza podataka koristeći otvoreni okvir čitanja (ORF) S. cerevisiae, Stanchi et al. (2001) identificirali su DDX52, kojeg su nazvali HUSSY19. Izvedeni protein sa 420 aminokiselina dijeli 45% identiteta s kvaščevim Rok1, navodnom ATP-ovisnom RNK-helikazom iz boksne porodice DEAD. Radijacijskom hibridnom analizom, mapirali su gen DDX52 u hromosomskoj regijiom 17q21.1.[7]
Dužina polipeptidnog lanca je 599 aminokiselina, a molekulska težina 67.498 Da.[8]
Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MDVHDLFRRL | GAGAKFDTRR | FSADAARFQI | GKRKYDFDSS | EVLQGLDFFG | ||||
| NKKSVPGVCG | ASQTHQKPQN | GEKKEESLTE | RKREQSKKKR | KTMTSEIASQ | ||||
| EEGATIQWMS | SVEAKIEDKK | VQRESKLTSG | KLENLRKEKI | NFLRNKHKIH | ||||
| VQGTDLPDPI | ATFQQLDQEY | KINSRLLQNI | LDAGFQMPTP | IQMQAIPVML | ||||
| HGRELLASAP | TGSGKTLAFS | IPILMQLKQP | ANKGFRALII | SPTRELASQI | ||||
| HRELIKISEG | TGFRIHMIHK | AAVAAKKFGP | KSSKKFDILV | TTPNRLIYLL | ||||
| KQDPPGIDLA | SVEWLVVDES | DKLFEDGKTG | FRDQLASIFL | ACTSHKVRRA | ||||
| MFSATFAYDV | EQWCKLNLDN | VISVSIGARN | SAVETVEQEL | LFVGSETGKL | ||||
| LAMRELVKKG | FNPPVLVFVQ | SIERAKELFH | ELIYEGINVD | VIHAERTQQQ | ||||
| RDNTVHSFRA | GKIWVLICTA | LLARGIDFKG | VNLVINYDFP | TSSVEYIHRI | ||||
| GRTGRAGNKG | KAITFFTEDD | KPLLRSVANV | IQQAGCPVPE | YIKGFQKLLS | ||||
| KQKKKMIKKP | LERESISTTP | KCFLEKAKDK | QKKVTGQNSK | KKVALEDKS |
Reference
[uredi | uredi izvor]- 1 2 3 ENSG00000278053 GRCh38: Ensembl release 89: ENSG00000277594, ENSG00000278053 - Ensembl, maj 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020677 - Ensembl, maj 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
- ↑ "Entrez Gene: DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52".
- ↑ Stanchi, F., Bertocco, E., Toppo, S., Dioguardi, R., Simionati, B., Cannata, N., Zimbello, R., Lanfranchi, G., Valle, G. Characterization of 16 novel human genes showing high similarity to yeast sequences. Yeast 18: 69-80, 2001. PubMed: 11124703
- ↑ "UniProt, Q9Y2R4". Pristupljeno 22. 6. 2021.
Dopunska literatura
[uredi | uredi izvor]- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.