DOM3Z

DOM3Z
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	3FQI, 3FQJ, 4J7L, 4J7M, 4J7N
Identifikatori
Aliasi	DXO
Vanjski ID-jevi	OMIM: 605996 MGI: 1890444 HomoloGene: 38061 GeneCards: DXO
Lokacija gena (čovjek)
Hrom.	Hromosom 6 (čovjek)
Kraj	31,972,290 bp
Lokacija gena (miš)
Hrom.	Hromosom 17 (miš)
Kraj	35,058,209 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • nuclease activity; • 5'-3' exonuclease activity; • exonuclease activity; • mRNA binding; • RNA pyrophosphohydrolase activity; • hydrolase activity; • magnesium ion binding; • vezivanje iona metala; • vezivanje sa RNK;
Ćelijska komponenta	• ćelijska membrana; • jedro; • citosol;
Biološki proces	• GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance; • mRNA catabolic process; • RNA destabilization; • nucleic acid phosphodiester bond hydrolysis;
	Izvori:Amigo / QuickGO
Ortolozi
	1797
	112403
ENSG00000204348; ENSG00000236765; ENSG00000224313; ENSG00000206346; ENSG00000225682;
	ENSG00000234798
	ENSMUSG00000040482
	O77932
	O70348
	NM_005510; NM_001371205; NM_001371206
	NM_001163770; NM_033613
	NP_005501; NP_001358134; NP_001358135
	NP_001157242; NP_291091
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein Dom3Z jest protein koji je kod ljudi kodiran genom DOM3Z.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 396 aminokiselina, а molekulska težina 44.929 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MDPRGTKRGA	EKTEVAEPRN	KLPRPAPSLP	TDPALYSGPF	PFYRRPSELG
CFSLDAQRQY	HGDARALRYY	SPPPTNGPGP	NFDLRDGYPD	RYQPRDEEVQ
ERLDHLLCWL	LEHRGRLEGG	PGWLAEAIVT	WRGHLTKLLT	TPYERQEGWQ
LAASRFQGTL	YLSEVETPNA	RAQRLARPPL	LRELMYMGYK	FEQYMCADKP
GSSPDPSGEV	NTNVAFCSVL	RSRLGSHPLL	FSGEVDCTDP	QAPSTQPPTC
YVELKTSKEM	HSPGQWRSFY	RHKLLKWWAQ	SFLPGVPNVV	AGFRNPDGFV
SSLKTFPTMK	MFEYVRNDRD	GWNPSVCMNF	CAAFLSFAQS	TVVQDDPRLV
HLFSWEPGGP	VTVSVHQDAP	YAFLPIWYVE	AMTQDLPSPP	KTPSPK

Funkcija[uredi | uredi izvor]

Ovaj gen se lokalizira u glavnom kompleksu histokompatibilnosti (MHC) klase III na hromosomu 6. Funkcija njegovog proteinskog proizvoda je nepoznata, ali njegova sveprisutna ekspresija i konzeviranost i kod jednostavnih i kod složenih eukariota sugerira da bi to moglo biti domaćinski gen.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040482 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.
^ ^a ^b "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".
^ "UniProt, O77932" (jezik: engleski). Pristupljeno 1. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster". Exp. Clin. Immunogenet. 15 (4): 213–30. doi:10.1159/000019075. PMID 10072631. S2CID 25061446.
Yang Z, Yu CY (2000). "Organizations and gene duplications of the human and mouse MHC complement gene clusters". Exp. Clin. Immunogenet. 17 (1): 1–17. doi:10.1159/000019119. PMID 10686478. S2CID 45164668.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 GRCh38: Ensembl release 89: ENSG00000204348, ENSG00000236765, ENSG00000224313, ENSG00000206346, ENSG00000225682, ENSG00000234798 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040482 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9799600-5] Yang Z, Shen L, Dangel AW, Wu LC, Yu CY (Dec 1998). "Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z-RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA". Genomics. 53 (3): 338–47. doi:10.1006/geno.1998.5499. PMID 9799600.

[entrez-6] "Entrez Gene: DOM3Z dom-3 homolog Z (C. elegans)".

[UniProt-7] "UniProt, O77932" (jezik: engleski). Pristupljeno 1. 10. 2021.

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