EDEM2
ER-degradacijskopojačavajući alfa-manozidazoliki protein jest enzim koji je kod ljudi kodiran genom EDEM2 sa hromosoma 20.[5][6][7]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 578 aminokiselina, a molekulska težina 64.753 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPFRLLIPLG | LLCALLPQHH | GAPGPDGSAP | DPAHYRERVK | AMFYHAYDSY | ||||
| LENAFPFDEL | RPLTCDGHDT | WGSFSLTLID | ALDTLLILGN | VSEFQRVVEV | ||||
| LQDSVDFDID | VNASVFETNI | RVVGGLLSAH | LLSKKAGVEV | EAGWPCSGPL | ||||
| LRMAEEAARK | LLPAFQTPTG | MPYGTVNLLH | GVNPGETPVT | CTAGIGTFIV | ||||
| EFATLSSLTG | DPVFEDVARV | ALMRLWESRS | DIGLVGNHID | VLTGKWVAQD | ||||
| AGIGAGVDSY | FEYLVKGAIL | LQDKKLMAMF | LEYNKAIRNY | TRFDDWYLWV | ||||
| QMYKGTVSMP | VFQSLEAYWP | GLQSLIGDID | NAMRTFLNYY | TVWKQFGGLP | ||||
| EFYNIPQGYT | VEKREGYPLR | PELIESAMYL | YRATGDPTLL | ELGRDAVESI | ||||
| EKISKVECGF | ATIKDLRDHK | LDNRMESFFL | AETVKYLYLL | FDPTNFIHNN | ||||
| GSTFDAVITP | YGECILGAGG | YIFNTEAHPI | DPAALHCCQR | LKEEQWEVED | ||||
| LMREFYSLKR | SRSKFQKNTV | SSGPWEPPAR | PGTLFSPENH | DQARERKPAK | ||||
| QKVPLLSCPS | QPFTSKLALL | GQVFLDSS |
References[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000088298 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038312 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW (Mar 2005). "Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins". Glycobiology. 15 (4): 421–36. doi:10.1093/glycob/cwi014. PMID 15537790.
- ^ Olivari S, Galli C, Alanen H, Ruddock L, Molinari M (Jan 2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J Biol Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
- ^ a b "Entrez Gene: EDEM2 ER degradation enhancer, mannosidase alpha-like 2".
Dopunska literatura[uredi | uredi izvor]
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.