ESM1

ESM1
Identifikatori
Aliasi	ESM1
Vanjski ID-jevi	OMIM: 601521 MGI: 1918940 HomoloGene: 5107 GeneCards: ESM1
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	55,022,671 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	113,354,632 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• integrin binding; • insulin-like growth factor binding; • hepatocyte growth factor receptor binding;
Ćelijska komponenta	• extracellular region;
Biološki proces	• sprouting angiogenesis; • regulation of cell growth; • Angiogeneza; • positive regulation of cell population proliferation; • positive regulation of hepatocyte growth factor receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	11082
	71690
	ENSG00000164283
	ENSMUSG00000042379
	Q9NQ30
	Q9QYY7
	NM_007036; NM_001135604
	NM_023612
	NP_001129076; NP_008967
	NP_076101
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Endotelna ćelijski specifična molekula 1 jest protein koji je kod ljudi kodiran genom ESM1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 184 aminokiseline, а molekulska težina 20.095 Da.^[7].

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MKSVLLLTTL	LVPAHLVAAW	SNNYAVDCPQ	HCDSSECKSS	PRCKRTVLDD
CGCCRVCAAG	RGETCYRTVS	GMDGMKCGPG	LRCQPSNGED	PFGEEFGICK
DCPYGTFGMD	CRETCNCQSG	ICDRGTGKCL	KFPFFQYSVT	KSSNRFVSLT
EHDMASGDGN	IVREEVVKEN	AAGSPVMRKW	LNPR

Funkcija[uredi | uredi izvor]

Ovaj gen kodira izlučeni protein koji se uglavnom eksprimira u endotelnim ćelijama u ljudskim plućnim i bubrežnim tkivima. Ekspresiju ovog gena reguliraju citokini, što sugerira da on može imati ulogu u patološkim poremećajima ovisnim o endotelu. Transkript sadrži više signala nestabilnosti poliadenilacije i iRNK.^[6]

Genski proizvod ESM-1 također se naziva endokan, od 2001. godine, kada su ga Bechard et al. okarakterizirali kao dermatan-sulfat proteoglikan. Nedavno su nezavisni timovi opisali endokan/ESM-1 kao specifični biomarker vršnih ćelija tokom neoangiogeneze. Pokazalo se da je ekspresija endokana povećana u prisutnosti proangiogenih faktora rasta, kao što je faktor rasta vaskularnog endotela (VEGF) ili faktor rasta fibroblasta 2 (FGF-2). Kod hipervaskulariziranih karcinoma, imunohistohemijski otkrivena je prekomjerna ekspresija endokana, upotrebom monoklonskih antitijela protiv endokana/ESM-1.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164283 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042379 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lassalle P, Molet S, Janin A, Heyden JV, Tavernier J, Fiers W, Devos R, Tonnel AB (Oct 1996). "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines". J Biol Chem. 271 (34): 20458–64. doi:10.1074/jbc.271.34.20458. PMID 8702785.
^ ^a ^b "Entrez Gene: ESM1 endothelial cell-specific molecule 1".
^ "UniProt, Q9NQ30" (jezik: engleski). Pristupljeno 14. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Bechard D, Meignin V, Scherpereel A, et al. (2000). "Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies". J. Vasc. Res. 37 (5): 417–25. doi:10.1159/000025758. PMID 11025405. S2CID 22931177.
Béchard D, Scherpereel A, Hammad H, et al. (2001). "Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1". J. Immunol. 167 (6): 3099–106. doi:10.4049/jimmunol.167.6.3099. PMID 11544294.
Aitkenhead M, Wang SJ, Nakatsu MN, et al. (2002). "Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM". Microvascular Research. 63 (2): 159–71. doi:10.1006/mvre.2001.2380. PMID 11866539.
Tsai JC, Zhang J, Minami T, et al. (2002). "Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter". J. Vasc. Res. 39 (2): 148–59. doi:10.1159/000057763. PMID 12011586. S2CID 40049627.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wellner M, Herse F, Janke J, et al. (2004). "Endothelial cell specific molecule-1--a newly identified protein in adipocytes". Horm. Metab. Res. 35 (4): 217–21. doi:10.1055/s-2003-39477. PMID 12778364.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Cong R, Jiang X, Wilson CM, et al. (2006). "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)". Biochem. Biophys. Res. Commun. 346 (2): 535–45. doi:10.1016/j.bbrc.2006.05.153. PMID 16764824.
Grigoriu BD, Depontieu F, Scherpereel A, et al. (2007). "Endocan expression and relationship with survival in human non-small cell lung cancer". Clin. Cancer Res. 12 (15): 4575–82. doi:10.1158/1078-0432.CCR-06-0185. PMID 16899604.
Rennel E, Mellberg S, Dimberg A, et al. (2007). "Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer". Exp. Cell Res. 313 (7): 1285–94. doi:10.1016/j.yexcr.2007.01.021. PMID 17362927.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164283 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042379 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8702785-5] Lassalle P, Molet S, Janin A, Heyden JV, Tavernier J, Fiers W, Devos R, Tonnel AB (Oct 1996). "ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines". J Biol Chem. 271 (34): 20458–64. doi:10.1074/jbc.271.34.20458. PMID 8702785.

[entrez-6] "Entrez Gene: ESM1 endothelial cell-specific molecule 1".

[UniProt-7] "UniProt, Q9NQ30" (jezik: engleski). Pristupljeno 14. 10. 2021.

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