EZH2

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EZH2
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4MI0, 4MI5, 5HYN, 5IJ8, 5IJ7

Identifikatori
AliasiEZH2
Vanjski ID-jeviOMIM: 601573 MGI: 107940 HomoloGene: 37926 GeneCards: EZH2
Lokacija gena (čovjek)
Hromosom 7 (čovjek)
Hrom.Hromosom 7 (čovjek)[1]
Hromosom 7 (čovjek)
Genomska lokacija za EZH2
Genomska lokacija za EZH2
Bend7q36.1Početak148,807,257 bp[1]
Kraj148,884,321 bp[1]
Lokacija gena (miš)
Hromosom 6 (miš)
Hrom.Hromosom 6 (miš)[2]
Hromosom 6 (miš)
Genomska lokacija za EZH2
Genomska lokacija za EZH2
Bend6 B2.3|6 22.92 cMPočetak47,530,139 bp[2]
Kraj47,595,341 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija GO:0102674, GO:0102675 methyltransferase activity
sequence-specific DNA binding
transferase activity
promoter-specific chromatin binding
chromatin binding
histone-lysine N-methyltransferase activity
protein-lysine N-methyltransferase activity
GO:0001948, GO:0016582 protein binding
RNA binding
ribonucleoprotein complex binding
chromatin DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
primary miRNA binding
DNA binding
histone methyltransferase activity
histone methyltransferase activity (H3-K27 specific)
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001106 transcription corepressor activity
Ćelijska komponenta ESC/E(Z) complex
pronucleus
Jedro
Nukleoplazma
citoplazma
Telomera
Biološki proces regulation of protein phosphorylation
regulation of gliogenesis
response to estradiol
GO:0009373 regulation of transcription, DNA-templated
positive regulation of MAP kinase activity
rhythmic process
negative regulation of retinoic acid receptor signaling pathway
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
negative regulation of striated muscle cell differentiation
G1 to G0 transition
GO:1901227 negative regulation of transcription by RNA polymerase II
positive regulation of dendrite development
positive regulation of epithelial to mesenchymal transition
negative regulation of transcription elongation from RNA polymerase II promoter
transcription, DNA-templated
negative regulation of DNA-binding transcription factor activity
positive regulation of protein serine/threonine kinase activity
negative regulation of gene expression
GO:1990376 negative regulation of G1/S transition of mitotic cell cycle
histone H3-K27 methylation
GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity
Metilacija DNK
negative regulation of epidermal cell differentiation
Metilacija
negative regulation of gene expression, epigenetic
regulation of cell population proliferation
regulation of circadian rhythm
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
cerebellar cortex development
Regulacija ekspresije gena
GO:0045996 negative regulation of transcription, DNA-templated
protein localization to chromatin
hippocampus development
regulation of neurogenesis
cellular response to hydrogen peroxide
response to tetrachloromethane
cellular response to trichostatin A
histone H3-K27 trimethylation
cardiac muscle hypertrophy in response to stress
hepatocyte homeostasis
liver regeneration
Metilacija histona
negative regulation of G0 to G1 transition
GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
positive regulation of cell population proliferation
positive regulation of cell cycle G1/S phase transition
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001203247
NM_001203248
NM_001203249
NM_004456
NM_152998

NM_001146689
NM_007971

RefSeq (bjelančevina)

NP_001190176
NP_001190177
NP_001190178
NP_004447
NP_694543

NP_001140161
NP_031997

Lokacija (UCSC)Chr 7: 148.81 – 148.88 MbChr 6: 47.53 – 47.6 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

EGFR-antisens RNK 1 je protein koji je kod ljudi kodiran genom EGFR-AS1.[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 746 aminokiselina, а molekulska težina 85.363 Da.[6]

1020304050
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKIL
ERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKT
LNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELI
KNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPEEREEKQ
KDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEELKEKYKELTEQ
QLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRP
GGRRRGRLPNNSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEK
KDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDN
FCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWA
AHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCS
SECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDE
ADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVM
MVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP

Funkcija[uredi | uredi izvor]

U jednoj od nedavnih studuja, konstatira se da dugolančane nekodirajuće RNK imaju bitnu ulogu u progresiji raka mokraćnog mjehura i ukazuje da je potrebno je dodatno proučiti ulogu duge nekodirajuće RNK EGFR-AS1 u karcinomu mjehura. Koristili su kliničke uzorke za analizu odnosa između EGFR-AS1 i karakteristika pacijenata s rakom mjehura. Funkcionalni eksperimenti i studije mehanizama izvedeni su pomoću qRT-PCR, transwell testa, analize preživljavanja i korelacijske analize. Otkrili su da je visoka ekspresija EGFR-AS1 gotovo povezana s agresivnim karcinomom mjehura i ukazuje na lošu prognozu za pacijente. Funkcionalni eksperimenti in vivo i in vitro sugerirali su da EGFR-AS1 podstiče proliferaciju i invaziju ćelija raka mjehura. Mehanički, EGFR-AS1 je promovirao ekspresiju EGFR-a inhibiranjem razgradnje EGFR-ove iRNK, čime se podstiče metastaziranje raka mjehura. Osim toga, EGFR-AS1/EGFR može biti uključen u imunološke puteve raka mjehura. Ove studije ukazuju da put EGFR-AS1/EGFR može biti potencijalni dijagnostički marker i terapeutska meta za rak mokraćnog mjehura.[7]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106462 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029687 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EGFR antisense RNA 1". Pristupljeno 6. 9. 2016.
  6. ^ "UniProt, Q15910" (jezik: engleski). Pristupljeno 23. 9. 2021.
  7. ^ Anbang Wang , Aimin Jiang , Xinxin Gan, Zheng Wang , Jinming Huang, Kai Dong, Bing Liu, Linhui Wang, Ming Chen (2020): Affiliations expand EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR. Biomed Res Int 6665974; pmid: 33426060; pmcid: pmc7781701; doi: 10.1155/2020/6665974