FAM107A

FAM107A
Identifikatori
Aliasi	FAM107A
Vanjski ID-jevi	OMIM: 608295 MGI: 3041256 HomoloGene: 48509 GeneCards: FAM107A
Lokacija gena (čovjek)
Hrom.	Hromosom 3 (čovjek)
Kraj	58,627,610 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	14,173,499 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • molekularna funkcija; • actin binding;
Ćelijska komponenta	• neuron projection; • jedro; • nuclear speck; • stress fiber; • citoplazma; • focal adhesion; • actin cytoskeleton; • ruffle membrane; • sinapsa; • citoskelet; • ćelijska membrana; • membrana; • međućelijske veze; • projekcija ćelije;
Biološki proces	• regulation of growth; • regulation of cell growth; • actin filament polymerization; • positive regulation of cell migration; • positive regulation of protein ubiquitination; • regulation of protein stability; • cellular response to nutrient levels; • regulation of actin cytoskeleton organization; • kognitivna funkcija; • actin filament bundle assembly; • negative regulation of focal adhesion assembly; • regulation of microtubule cytoskeleton organization; • cellular response to glucocorticoid stimulus; • negative regulation of long-term synaptic potentiation; • GO:1990376 negative regulation of G1/S transition of mitotic cell cycle; • ćelijski ciklus;
	Izvori:Amigo / QuickGO
Ortolozi
	11170
	268709
	ENSG00000168309
	ENSMUSG00000021750
	O95990
	Q78TU8
	NM_001076778; NM_001282713; NM_001282714; NM_007177
	NM_183187; NM_001360337; NM_001360338; NM_001360339
	NP_001070246; NP_001269642; NP_001269643; NP_009108; NP_001269643.1
	NP_001347266; NP_001347267; NP_001347268; NP_899010
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein FAM107A jest protein koji je kod ljudi kodiran genom FAM107A sa hromosoma 3.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 144 aminokiseline, а molekulska težina 17.455 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MYSEIQRERA	DIGGLMARPE	YREWNPELIK	PKKLLNPVKA	SRSHQELHRE
LLMNHRRGLG	VDSKPELQRV	LEHRRRNQLI	KKKKEELEAK	RLQCPFEQEL
LRRQQRLNQL	EKPPEKEEDH	APEFIKVREN	LRRIATLTSE	EREL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168309 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021750 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang L, Darling J, Zhang JS, Liu W, Qian J, Bostwick D, Hartmann L, Jenkins R, Bardenhauer W, Schutte J, Opalka B, Smith DI (Feb 2000). "Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma". Genes Chromosomes Cancer. 27 (1): 1–10. doi:10.1002/(SICI)1098-2264(200001)27:1<1::AID-GCC1>3.0.CO;2-6. PMID 10564580.
^ Yamato T, Orikasa K, Fukushige S, Orikasa S, Horii A (Apr 2000). "Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3→p14.2 in renal cell carcinoma". Cytogenet Cell Genet. 87 (3–4): 291–5. doi:10.1159/000015452. PMID 10702698. S2CID 34558356.
^ "Entrez Gene: FAM107A family with sequence similarity 107, member A".
^ "UniProt, O95990" (jezik: engleski). Pristupljeno 3. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kholodnyuk ID, Kozireva S, Kost-Alimova M, et al. (2006). "Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice". Int. J. Cancer. 119 (1): 99–107. doi:10.1002/ijc.21794. PMID 16432833. S2CID 27171340.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168309 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021750 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10564580-5] Wang L, Darling J, Zhang JS, Liu W, Qian J, Bostwick D, Hartmann L, Jenkins R, Bardenhauer W, Schutte J, Opalka B, Smith DI (Feb 2000). "Loss of expression of the DRR 1 gene at chromosomal segment 3p21.1 in renal cell carcinoma". Genes Chromosomes Cancer. 27 (1): 1–10. doi:10.1002/(SICI)1098-2264(200001)27:1<1::AID-GCC1>3.0.CO;2-6. PMID 10564580.

[pmid10702698-6] Yamato T, Orikasa K, Fukushige S, Orikasa S, Horii A (Apr 2000). "Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3→p14.2 in renal cell carcinoma". Cytogenet Cell Genet. 87 (3–4): 291–5. doi:10.1159/000015452. PMID 10702698. S2CID 34558356.

[entrez-7] "Entrez Gene: FAM107A family with sequence similarity 107, member A".

[UniProt-8] "UniProt, O95990" (jezik: engleski). Pristupljeno 3. 11. 2021.

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