FAM129A
Protein niban jest protein koji je kod ljudi kodiran genom FAM129A sa hromosoma 1.[5][6][7] Paralozi ovog proteina uključuju FAM129B i FAM129C.[8]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 928 aminokiselina, a molekulska težina 103.135 Da.[9]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MGGSASSQLD | EGKCAYIRGK | TEAAIKNFSP | YYSRQYSVAF | CNHVRTEVEQ | ||||
| QRDLTSQFLK | TKPPLAPGTI | LYEAELSQFS | EDIKKWKERY | VVVKNDYAVE | ||||
| SYENKEAYQR | GAAPKCRILP | AGGKVLTSED | EYNLLSDRHF | PDPLASSEKE | ||||
| NTQPFVVLPK | EFPVYLWQPF | FRHGYFCFHE | AADQKRFSAL | LSDCVRHLNH | ||||
| DYMKQMTFEA | QAFLEAVQFF | RQEKGHYGSW | EMITGDEIQI | LSNLVMEELL | ||||
| PTLQTDLLPK | MKGKKNDRKR | TWLGLLEEAY | TLVQHQVSEG | LSALKEECRA | ||||
| LTKGLEGTIR | SDMDQIVNSK | NYLIGKIKAM | VAQPAEKSCL | ESVQPFLASI | ||||
| LEELMGPVSS | GFSEVRVLFE | KEVNEVSQNF | QTTKDSVQLK | EHLDRLMNLP | ||||
| LHSVKMEPCY | TKVNLLHERL | QDLKSRFRFP | HIDLVVQRTQ | NYMQELMENA | ||||
| VFTFEQLLSP | HLQGEASKTA | VAIEKVKLRV | LKQYDYDSST | IRKKIFQEAL | ||||
| VQITLPTVQK | ALASTCKPEL | QKYEQFIFAD | HTNMIHVENV | YEEILHQILL | ||||
| DETLKVIKEA | AILKKHNLFE | DNMALPSESV | SSLTDLKPPT | GSNQASPARR | ||||
| ASAILPGVLG | SETLSNEVFQ | ESEEEKQPEV | PSSLAKGESL | SLPGPSPPPD | ||||
| GTEQVIISRV | DDPVVNPVAT | EDTAGLPGTC | SSELEFGGTL | EDEEPAQEEP | ||||
| EPITASGSLK | ALRKLLTASV | EVPVDSAPVM | EEDTNGESHV | PQENEEEEEK | ||||
| EPSQAAAIHP | DNCEESEVSE | REAQPPCPEA | HGEELGGFPE | VGSPASPPAS | ||||
| GGLTEEPLGP | MEGELPGEAC | TLTAHEGRGG | KCTEEGDASQ | QEGCTLGSDP | ||||
| ICLSESQVSE | EQEEMGGQSS | AAQATASVNA | EEIKVARIHE | CQWVVEDAPN | ||||
| PDVLLSHKDD | VKEGEGGQES | FPELPSEE |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000135842 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026483 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cerutti JM, Delcelo R, Amadei MJ, Nakabashi C, Maciel RM, Peterson B, Shoemaker J, Riggins GJ (Apr 2004). "A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression". J Clin Invest. 113 (8): 1234–42. doi:10.1172/JCI19617. PMC 385398. PMID 15085203.
- ^ Maciel RM, Kimura ET, Cerutti JM (Jan 2006). "[Pathogenesis of differentiated thyroid cancer (papillary and follicular)]". Arq Bras Endocrinol Metabol. 49 (5): 691–700. doi:10.1590/S0004-27302005000500009. PMID 16444351.
- ^ "Entrez Gene: FAM129A family with sequence similarity 129, member A".
- ^ https://www.genecards.org/cgi-bin/carddisp.pl?gene=FAM129A&search=0dc06d32f4b1591dfb90a182c78a6d99
- ^ "UniProt, Q9BZQ8" (jezik: en.). Pristupljeno 10. 12. 2021.CS1 održavanje: nepoznati jezik (link)
Dopunska literatura[uredi | uredi izvor]
- Majima S, Kajino K, Fukuda T, et al. (2000). "A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach". Jpn. J. Cancer Res. 91 (9): 869–74. doi:10.1111/j.1349-7006.2000.tb01027.x. PMC 5926447. PMID 11011112.
- Sood R, Bonner TI, Makalowska I, et al. (2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Matsumoto F, Fujii H, Abe M, et al. (2007). "A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis". Hum. Pathol. 37 (12): 1592–600. doi:10.1016/j.humpath.2006.06.022. PMID 16949643.