S Wikipedije, slobodne enciklopedije
Jedini protein F-kutije 28 jest protein koji je kod ljudi kodiran genom FBXO28 sa hromosoma 1 .[5] [6]
Dužina polipeptidnog lanca je 368 aminokiselina , a molekulska težina 41.149 Da .[7]
10 20 30 40 50 MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA PALAPDQLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK ATEAIDSLRK SKRLRNRK
Članovi porodice proteina F-kutije, kao što je FBXO28, karakteriziraju se približno 40-aminokiselinski motiv F-kutije. SCF kompleksi, formirani od SKP1 (MIM 601434), kulina (vidi CUL1; MIM 603134) i proteina F-kutije, djeluju kao protein-ubikvitin-ligaze . Proteini F-kutije stupaju u interakciju sa SKP1 preko F-kutije, a oni u interakciji sa ciljevima ubikvitinacije preko drugih domena interakcije proteina (Jin et al., 2004, OMIM [6]
^ a b c GRCh38: Ensembl release 89: ENSG00000143756 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047539 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain" . DNA Res . 4 (5): 345–9. doi :10.1093/dnares/4.5.345 PMID 9455484 . ^ a b "Entrez Gene: FBXO28 F-box protein 28" .^ "UniProt, Q9NVF7" (jezik: en.). Pristupljeno 10. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Jin J, Cardozo T, Lovering RC, et al. (2005). "Systematic analysis and nomenclature of mammalian F-box proteins" . Genes Dev . 18 (21): 2573–80. doi :10.1101/gad.1255304 . PMC 525538 PMID 15520277 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . 
