S Wikipedije, slobodne enciklopedije
FMR1 antisens RNK 1 (FMR1-AS1), znana i kao ASFMR1 ili FMR4 – u molekulskoj biologiji – je duga nekodirajuća RNK. Gen FMR1-AS1 preklapa se kao antisens CGG ponavljajuće regije gena FMR1.[3] Njegova ekspresija je pojačano regulirana u premutaciji sindroma fragilnog X, a utišana kod pacijenata s sindromom fragilnog X-a.[3][4] FMR1-AS1 ima antiapoptoznu funkciju.[4]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000268066 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, et al. (2007). "An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals". Hum Mol Genet. 16 (24): 3174–3187. doi:10.1093/hmg/ddm293. PMID 17921506.
- ^ a b Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C (2008). "A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome". PLOS ONE. 3 (1): e1486. Bibcode:2008PLoSO...3.1486K. doi:10.1371/journal.pone.0001486. PMC 2194623. PMID 18213394.
