S Wikipedije, slobodne enciklopedije
Gastrokin-1 jest protein koji je kod ljudi kodiran genom GKN1 sa hromosoma 2 .[5] [6] [7]
Dužina polipeptidnog lanca je 199 aminokiselina , a molkekulska iežina 21.999 Da .[8]
10 20 30 40 50 MLAYSSVHCF REDKMKFTIV FAGLLGVFLA PALANYNINV NDDNNNAGSG QQSVSVNNEH NVANVDNNNG WDSWNSIWDY GNGFAATRLF QKKTCIVHKM NKEVMPSIQS LDALVKEKKL QGKGPGGPPP KGLMYSVNPN KVDDLSKFGK NIANMCRGIP TYMAEEMQEA SLFFYSGTCY TTSVLWIVDI SFCGDTVEN
Utvrđeno je da je razina proteina kodiranog ovim genom smanjene u ljudskom tkivu raka želuca , u poređenju sa normalnom želučanom sluzokožom .[7]
^ a b c GRCh38: Ensembl release 89: ENSG00000169605 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030050 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (august 2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa" (PDF) . American Journal of Physiology. Gastrointestinal and Liver Physiology . 285 (2): G332-43. doi :10.1152/ajpgi.00453.2002 . PMID 12851218 . S2CID 2860022 . Arhivirano s originala (PDF) , 2. 3. 2019. ^ Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, et al. (oktobar 2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer". International Journal of Oncology . 19 (4): 701–7. doi :10.3892/ijo.19.4.701 . PMID 11562744 . ^ a b "Entrez Gene: GKN1 gastrokine 1" .^ "UniProt, Q9NS71" (jezik: engleski). Pristupljeno 12. 11. 2021 .
Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (maj 2000). "Isolation of two novel genes, down-regulated in gastric cancer" . Japanese Journal of Cancer Research . 91 (5): 459–63. doi :10.1111/j.1349-7006.2000.tb00967.x . PMC 5926377 PMID 10835488 . Westley BR, Griffin SM, May FE (juni 2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C". Biochemistry . 44 (22): 7967–75. doi :10.1021/bi047287n . PMID 15924415 . Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG (juli 2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins" . American Journal of Physiology. Gastrointestinal and Liver Physiology . 289 (1): G163-71. doi :10.1152/ajpgi.00013.2005 . PMC 1444946 PMID 15961882 . Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, et al. (februar 2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection". Digestive and Liver Disease . 39 (2): 122–9. doi :10.1016/j.dld.2006.09.017 . PMID 17092786 . 
