GLCE

GLCE
Identifikatori
Aliasi	GLCE
Vanjski ID-jevi	OMIM: 612134 MGI: 2136405 HomoloGene: 14111 GeneCards: GLCE
Lokacija gena (čovjek)
Hrom.	Hromosom 15 (čovjek)
Kraj	69,272,217 bp
Lokacija gena (miš)
Hrom.	Hromosom 9 (miš)
Kraj	62,029,937 bp
Ontologija gena
Molekularna funkcija	• racemase and epimerase activity, acting on carbohydrates and derivatives; • isomerase activity; • heparosan-N-sulfate-glucuronate 5-epimerase activity;
Ćelijska komponenta	• integral component of membrane; • Golđijeva membrana; • Golđijev aparat; • membrana;
Biološki proces	• heparan sulfate proteoglycan biosynthetic process; • heparin biosynthetic process; • glycosaminoglycan biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	26035
	93683
	ENSG00000138604
	ENSMUSG00000032252
	O94923
	Q9EPS3
	NM_015554; NM_001324091; NM_001324092; NM_001324093; NM_001324094
	NM_033320; NM_001368304
	NP_001311020; NP_001311021; NP_001311022; NP_001311023; NP_056369
	NP_201577; NP_001355233
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

D-glukuronil C5-epimeraza je enzim koji je kod ljudi kodiran genom GLCE.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 617 aminokiselina, a molekulska težina 70.101 Da.^[7]

10	20	30	40	50
MRCLAARVNY	KTLIIICALF	TLVTVLLWNK	CSSDKAIQFP	RRSSSGFRVD
GFEKRAAASE	SNNYMNHVAK	QQSEEAFPQE	QQKAPPVVGG	FNSNVGSKVL
GLKYEEIDCL	INDEHTIKGR	REGNEVFLPF	TWVEKYFDVY	GKVVQYDGYD
RFEFSHSYSK	VYAQRAPYHP	DGVFMSFEGY	NVEVRDRVKC	ISGVEGVPLS
TQWGPQGYFY	PIQIAQYGLS	HYSKNLTEKP	PHIEVYETAE	DRDKNKPNDW
TVPKGCFMAN	VADKSRFTNV	KQFIAPETSE	GVSLQLGNTK	DFIISFDLKF
LTNGSVSVVL	ETTEKNQLFT	IHYVSNAQLI	AFKERDIYYG	IGPRTSWSTV
TRDLVTDLRK	GVGLSNTKAV	KPTKIMPKKV	VRLIAKGKGF	LDNITISTTA
HMAAFFAASD	WLVRNQDEKG	GWPIMVTRKL	GEGFKSLEPG	WYSAMAQGQA
ISTLVRAYLL	TKDHIFLNSA	LRATAPYKFL	SEQHGVKAVF	MNKHDWYEEY
PTTPSSFVLN	GFMYSLIGLY	DLKETAGEKL	GKEARSLYER	GMESLKAMLP
LYDTGSGTIY	DLRHFMLGIA	PNLARWDYHT	THINQLQLLS	TIDESPVFKE
FVKRWKSYLK	GSRAKHN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.
^ "Entrez Gene: GLCE glucuronic acid epimerase".
^ "UniProt, O94923". Pristupljeno 14. 7. 2021.

Dopunska literatura[uredi | uredi izvor]

Grigorieva E, Eshchenko T, Rykova VI, et al. (2008). "Decreased expression of human D-glucuronyl C5-epimerase in breast cancer". Int. J. Cancer. 122 (5): 1172–6. doi:10.1002/ijc.23203. PMID 17985344.
Hagner-McWhirter A, Li JP, Oscarson S, Lindahl U (2004). "Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate". J. Biol. Chem. 279 (15): 14631–8. doi:10.1074/jbc.M313760200. PMID 14718527.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Crawford BE, Olson SK, Esko JD, Pinhal MA (2001). "Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase". J. Biol. Chem. 276 (24): 21538–43. doi:10.1074/jbc.M100880200. PMID 11279150.
Li JP, Gong F, El Darwish K, et al. (2001). "Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate". J. Biol. Chem. 276 (23): 20069–77. doi:10.1074/jbc.M011783200. PMID 11274177.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138604 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032252 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15853773-5] Ghiselli G, Agrawal A (Aug 2005). "The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the β-catenin–TCF4 pathway". Biochem J. 390 (Pt 2): 493–9. doi:10.1042/BJ20050152. PMC 1198929. PMID 15853773.

[entrez-6] "Entrez Gene: GLCE glucuronic acid epimerase".

[UniProt-7] "UniProt, O94923". Pristupljeno 14. 7. 2021.

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