HES3

HES3
Identifikatori
Aliasi	HES3
Vanjski ID-jevi	OMIM: 609971 MGI: 104877 HomoloGene: 7358 GeneCards: HES3
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	6,245,578 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	152,376,119 bp
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • transcription factor binding; • protein dimerization activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001106 transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
Ćelijska komponenta	• jedro;
Biološki proces	• hindbrain morphogenesis; • trochlear nerve development; • midbrain-hindbrain boundary morphogenesis; • GO:0045996 negative regulation of transcription, DNA-templated; • in utero embryonic development; • GO:1901227 negative regulation of transcription by RNA polymerase II; • GO:0009373 regulation of transcription, DNA-templated; • regulation of timing of neuron differentiation; • regulation of neurogenesis; • oculomotor nerve development; • transcription, DNA-templated; • midbrain development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • neural tube development; • somitogenesis; • Notch signaling pathway; • Ćelijska diferencijacija; • anterior/posterior pattern specification;
	Izvori:Amigo / QuickGO
Ortolozi
	390992
	15207
	ENSG00000173673
	ENSMUSG00000028946
	Q5TGS1
	Q61657
	NM_001024598
	NM_008237
	NP_001019769
	NP_032263; NP_001390720; NP_001390721; NP_001390722; NP_001390723
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transkripcijski faktor 3 Hes porodice bHLH jest protein koji je kod ljudi kodiran genom HES3 sa hromosoma 1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 186 aminokiselina, a molekulska težina 19.968 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEKKRRARIN	VSLEQLKSLL	EKHYSHQIRK	RKLEKADILE	LSVKYMRSLQ
NSLQGLWPVP	RGAEQPSGFR	SCLPGVSQLL	RRGDEVGSGL	RCPLVPESAA
GSTMDSAGLG	QEAPALFRPC	TPAVWAPAPA	AGGPRSPPPL	LLLPESLPGS
SASVPPPQPA	SSRCAESPGL	GLRVWRPWGS	PGDDLN

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173673 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028946 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Hes family bHLH transcription factor 3".
^ "UniProt, Q5TGS1" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Katoh M, Katoh M (august 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
Katoh M, Katoh M (august 2007). "Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer". International Journal of Oncology. 31 (2): 461–6. doi:10.3892/ijo.31.2.461. PMID 17611704.
Fukami M, Wada Y, Okada M, Kato F, Katsumata N, Baba T, Morohashi K, Laporte J, Kitagawa M, Ogata T (februar 2008). "Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence". The Journal of Biological Chemistry. 283 (9): 5525–32. doi:10.1074/jbc.M703289200. PMID 18162467.
Park DM, Jung J, Masjkur J, Makrogkikas S, Ebermann D, Saha S, Rogliano R, Paolillo N, Pacioni S, McKay RD, Poser S, Androutsellis-Theotokis A (2013). "Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics". Scientific Reports. 3: 1095. Bibcode:2013NatSR...3E1095P. doi:10.1038/srep01095. PMC 3566603. PMID 23393614.

Vanjski linkovi[uredi | uredi izvor]

Šablon:Transkripcijski faktori i unutarćelijski receptori

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173673 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028946 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Hes family bHLH transcription factor 3".

[UniProt-6] "UniProt, Q5TGS1" (jezik: eng.). Pristupljeno 28. 11. 2021.CS1 održavanje: nepoznati jezik (link)

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