HIST1H4L

S Wikipedije, slobodne enciklopedije
HIST1H4L
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX

Identifikatori
AliasiH4C13
Vanjski ID-jeviOMIM: 602831 MGI: 4843992 HomoloGene: 136248 GeneCards: H4C13
Lokacija gena (čovjek)
Hromosom 6 (čovjek)
Hrom.Hromosom 6 (čovjek)[1]
Hromosom 6 (čovjek)
Genomska lokacija za HIST1H4L
Genomska lokacija za HIST1H4L
Bend6p22.1Početak27,873,148 bp[1]
Kraj27,873,534 bp[1]
Lokacija gena (miš)
Hromosom 13 (miš)
Hrom.Hromosom 13 (miš)[2]
Hromosom 13 (miš)
Genomska lokacija za HIST1H4L
Genomska lokacija za HIST1H4L
Bend13|13 A3.1Početak22,015,937 bp[2]
Kraj22,016,366 bp[2]
Ontologija gena
Molekularna funkcija protein domain specific binding
GO:0001948, GO:0016582 protein binding
protein heterodimerization activity
DNA binding
GO:0031493 histone binding
RNA binding
Ćelijska komponenta membrana
hromosom
Nukleoplazma
extracellular region
nuclear chromosome
Nukleosom
Egzosom
Jedro
GO:0005578 Vanćelijski matriks
GO:0009327 protein-containing complex
Biološki proces telomere organization
epigenetic maintenance of chromatin in transcription-competent conformation
protein heterotetramerization
negative regulation of megakaryocyte differentiation
GO:0061641 CENP-A containing chromatin assembly
GO:0034723 DNA replication-dependent chromatin assembly
rDNA heterochromatin assembly
negative regulation of gene expression, epigenetic
DNA-templated transcription, initiation
double-strand break repair via nonhomologous end joining
beta-catenin-TCF complex assembly
telomere capping
nucleosome assembly
GO:1905616 regulation of gene silencing by miRNA
regulation of megakaryocyte differentiation
regulation of hematopoietic stem cell differentiation
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_003546

NM_175657

RefSeq (bjelančevina)
NP_003537
NP_003486
NP_003535
NP_003539
NP_003531

NP_003536

NP_291074
NP_783587
NP_783588
NP_835499
NP_835500

NP_001182350
NP_835515
NP_783585
NP_783586
NP_835582
NP_835583
NP_783583
NP_694813

Lokacija (UCSC)Chr 6: 27.87 – 27.87 MbChr 13: 22.02 – 22.02 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Histon H4 jest protein koji je kod ljudi kodiran genom HIST1H4L sa hromosoma 6.[5][6][7][8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 103 aminokiseline, a molekulska težina Da.[8]

1020304050
MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGL
IYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYG
FGG

Funkcija[uredi | uredi izvor]

Histoni su osnovni jedarni proteini koji su odgovorni za nukleosomsku strukturu hromosomskih vlakana u eukariotima. Dvije molekule svakog od četiri jezgra histona (H2A, H2B, H3 i H4) formiraju oktamer , oko kojeg je otprilike 146 bp DNK omotano u ponavljajuće jedinice, zvane nukleosomi. Linkerski histon, H1, stupa u interakciju sa linkerom DNK između nukleosoma i funkcionira u zbijanju hromatina u strukture višeg reda. Ovaj gen je bez introna i kodira člana porodice histona H4. Transkripti ovog gena nemaju repove polyA, ali umjesto toga sadrže palindromski terminski element. Ovaj gen se nalazi u malom klasteru histonskih gena na hromosomskom segmentu 6p22-p21.3.[8]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000275126 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069305 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
  6. ^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ a b c "Entrez Gene: HIST1H4L histone cluster 1, H4l".

Dopunska literatura[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]