HPCAL1

HPCAL1
Identifikatori
Aliasi	HPCAL1
Vanjski ID-jevi	OMIM: 600207 MGI: 1855689 HomoloGene: 37586 GeneCards: HPCAL1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	10,427,617 bp
Lokacija gena (miš)
Hrom.	Hromosom 12 (miš)
Kraj	17,791,933 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ortolozi
	3241
	53602
	ENSG00000115756
	ENSMUSG00000071379
	P37235
	P62748
	NM_001258357; NM_001258358; NM_001258359; NM_002149; NM_134421
	NM_016677; NM_001361645
	NP_001245286; NP_001245287; NP_001245288; NP_002140; NP_602293
	NP_057886; NP_001348574
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hipokalcinoliki protein 1 jest protein koji je kod ljudi kodiran genom HPCAL1 sa hromosoma 2.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 193 aminokiseline, a molekulska težina 22.313 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGKQNSKLRP	EVLQDLRENT	EFTDHELQEW	YKGFLKDCPT	GHLTVDEFKK
IYANFFPYGD	ASKFAEHVFR	TFDTNGDGTI	DFREFIIALS	VTSRGKLEQK
LKWAFSMYDL	DGNGYISRSE	MLEIVQAIYK	MVSSVMKMPE	DESTPEKRTD
KIFRQMDTNN	DGKLSLEEFI	RGAKSDPSIV	RLLQCDPSSA	SQF

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom je član neuron-specifične porodice proteina koji vezuju kalcij u mrežnjači i mozgu.^[9] Veoma je sličan ljudskom hipokalcinskom proteinu i skoro identičan hipokalcinu sličnim-1 proteinima pacova i miša. Može biti uključen u kalcij ovisnu regulaciju fosforilacije rodopsina, a može biti od značaja za neuronsku signalizaciju u centralnom nervnom sistemu. Postoje dvije alternativno prerađene varijante transkripta ovog gena, sa više mjesta poliadenilacija.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115756 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071379 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222.
^ Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275.
^ ^a ^b "Entrez Gene: HPCAL1 hippocalcin-like 1".
^ "UniProt, P37235" (jezik: engleski). Pristupljeno 13. 4. 2022.
^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Dopunska literatura[uredi | uredi izvor]

Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. doi:10.1016/0168-0102(93)90074-Z. PMID 8387172. S2CID 4210072.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Spilker C, Richter K, Smalla KH, et al. (2000). "The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association". Neuroscience. 96 (1): 121–9. doi:10.1016/S0306-4522(99)00536-9. PMID 10683417. S2CID 22063490.
Bernstein HG, Baumann B, Danos P, et al. (2000). "Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain". J. Neurocytol. 28 (8): 655–62. doi:10.1023/A:1007056731551. PMID 10851344. S2CID 7944931.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Braunewell K, Riederer P, Spilker C, et al. (2001). "Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (vilips)-1 and -3, in neocortical brain areas of Alzheimer disease patients". Dementia and Geriatric Cognitive Disorders. 12 (2): 110–6. doi:10.1159/000051244. PMID 11173883. S2CID 21446098.
Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.
Spilker C, Gundelfinger ED, Braunewell KH (2002). "Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3: from subcellular localization to cellular function". Biochim. Biophys. Acta. 1600 (1–2): 118–27. doi:10.1016/s1570-9639(02)00452-1. PMID 12445467.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pribanic S, Loffing J, Madjdpour C, et al. (2004). "Expression of visinin-like protein-3 in mouse kidney" (PDF). Nephron Physiology. 95 (4): 76–82. doi:10.1159/000074844. PMID 14694264. S2CID 4883128.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Jheng FF, Wang L, Lee L, Chang LS (2007). "Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteins". Protein J. 25 (4): 250–6. doi:10.1007/s10930-006-9008-5. PMID 16703469. S2CID 29486237.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115756 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071379 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8038222-5] Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222.

[pmid14739275-6] Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275.

[entrez-7] "Entrez Gene: HPCAL1 hippocalcin-like 1".

[UniProt-8] "UniProt, P37235" (jezik: engleski). Pristupljeno 13. 4. 2022.

[pmid17311005-9] Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

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