S Wikipedije, slobodne enciklopedije
Član 8 natporodice imunoglobulina jest protein koji je kod ljudi kodiran genom IGSF8 sa hromosoma 1 .[5] [6] [7] CD316 (klaster diferencijacije 316).
Dužina polipeptidnog lanca je 613 aminokiselina , a molekulska težina 65.034 Da .[8]
10 20 30 40 50 MGALRPTLLP PSLPLLLLLM LGMGCWAREV LVPEGPLYRV AGTAVSISCN VTGYEGPAQQ NFEWFLYRPE APDTALGIVS TKDTQFSYAV FKSRVVAGEV QVQRLQGDAV VLKIARLQAQ DAGIYECHTP STDTRYLGSY SGKVELRVLP DVLQVSAAPP GPRGRQAPTS PPRMTVHEGQ ELALGCLART STQKHTHLAV SFGRSVPEAP VGRSTLQEVV GIRSDLAVEA GAPYAERLAA GELRLGKEGT DRYRMVVGGA QAGDAGTYHC TAAEWIQDPD GSWAQIAEKR AVLAHVDVQT LSSQLAVTVG PGERRIGPGE PLELLCNVSG ALPPAGRHAA YSVGWEMAPA GAPGPGRLVA QLDTEGVGSL GPGYEGRHIA MEKVASRTYR LRLEAARPGD AGTYRCLAKA YVRGSGTRLR EAASARSRPL PVHVREEGVV LEAVAWLAGG TVYRGETASL LCNISVRGGP PGLRLAASWW VERPEDGELS SVPAQLVGGV GQDGVAELGV RPGGGPVSVE LVGPRSHRLR LHSLGPEDEG VYHCAPSAWV QHADYSWYQA GSARSGPVTV YPYMHALDTL FVPLLVGTGV ALVTGATVLG TITCCFMKRL RKR
^ a b c GRCh38: Ensembl release 89: ENSG00000162729 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038034 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily" . J Biol Chem . 276 (44): 40545–54. doi :10.1074/jbc.M107338200 PMID 11504738 . ^ Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins" . J Immunol . 167 (9): 5115–21. doi :10.4049/jimmunol.167.9.5115 PMID 11673522 . ^ "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8" .^ "UniProt, Q969P0" (jezik: en.). Pristupljeno 12. 12. 2021 .CS1 održavanje: nepoznati jezik (link )
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells" . Biochem. J . 373 (Pt 2): 409–21. doi :10.1042/BJ20030343 . PMC 1223506 PMID 12708969 . Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells". Cancer Res . 63 (10): 2665–74. PMID 12750295 . Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes" . Br. J. Dermatol . 148 (4): 654–64. doi :10.1046/j.1365-2133.2003.05244.x . PMID 12752121 . S2CID 21635573 . Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5" . J. Cell Biol . 163 (5): 1167–77. doi :10.1083/jcb.200309113 . PMC 2173626 PMID 14662754 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions" . Blood . 103 (8): 3013–9. doi :10.1182/blood-2003-07-2201 PMID 15070678 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization" . J. Biol. Chem . 281 (18): 12976–85. doi :10.1074/jbc.M510617200 PMID 16537545 . Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins" . J. Biol. Chem . 281 (28): 19665–75. doi :10.1074/jbc.M602116200 PMID 16690612 . Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells" . Mol. Cell. Biol . 27 (21): 7718–26. doi :10.1128/MCB.00180-07 . PMC 2169036 PMID 17785435 .
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