INTS6

INTS6
Identifikatori
Aliasi	INTS6
Vanjski ID-jevi	OMIM: 604331 MGI: 1202397 HomoloGene: 8121 GeneCards: INTS6
Lokacija gena (čovjek)
Hrom.	Hromosom 13 (čovjek)
Kraj	51,454,264 bp
Lokacija gena (miš)
Hrom.	Hromosom 14 (miš)
Kraj	62,998,618 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • transmembrane signaling receptor activity;
Ćelijska komponenta	• integrator complex; • actin cytoskeleton; • nukleoplazma; • jedro;
Biološki proces	• snRNA processing; • snRNA transcription by RNA polymerase II; • GO:0072468 Transdukcija signala; • snRNA 3'-end processing;
	Izvori:Amigo / QuickGO
Ortolozi
	26512
	18130
	ENSG00000102786
	ENSMUSG00000035161
	Q9UL03
	Q6PCM2
	NM_001039937; NM_001039938; NM_001306091; NM_012141
	NM_008715
	NP_001035026; NP_001035027; NP_001293020; NP_036273
	NP_032741
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica 6 integratorskog kompleksa je protein koji je kod ljudi kodiran genom INTS6, koji je lociran na hromosomu 13, sekvenca 13q14.3, u rasponu bazbih parova od 51,354.077 do 51,454.264 bp^[5]^[6]^[7]

Proteini DEAD-kutija, karakterizirani konzerviranim motivom Asp-Glu-Ala-Asp (DEAD), pretpostavljene su RNK-helikaze. Protein kodiran ovim genom je DEAD boksni protein, koji je dio kompleksa koji stupa u interakciju sa C-terminalom RNK-polimeraze II i uključen je u 3' završnu preradu snRNK. Osim toga, ovaj gen je kandidat kao supresorski gen tumora i nalazi se u kritičnoj regiji gubitka heterozigotnosti (LOH). Za ovaj gen su pronađene tri varijante transkripta koje kodiraju dvije različite izoforme.^[7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 887 aminokiselina, a molekulska težina 100.390 Da.^[8]

10	20	30	40	50
MPILLFLIDT	SASMNQRSHL	GTTYLDTAKG	AVETFMKLRA	RDPASRGDRY
MLVTFEEPPY	AIKAGWKENH	ATFMNELKNL	QAEGLTTLGQ	SLRTAFDLLN
LNRLVTGIDN	YGQGRNPFFL	EPAIIITITD	GSKLTTTSGV	QDELHLPLNS
PLPGSELTKE	PFRWDQRLFA	LVLRLPGTMS	VESEQLTGVP	LDDSAITPMC
EVTGGRSYSV	CSPRMLNQCL	ESLVQKVQSG	VVINFEKAGP	DPSPVEDGQP
DISRPFGSQP	WHSCHKLIYV	RPNPKTGVPI	GHWPVPESFW	PDQNSPTLPP
RTSHPVVKFS	CTDCEPMVID	KLPFDKYELE	PSPLTQFILE	RKSPQTCWQV
YVSNSAKYSE	LGHPFGYLKA	STALNCVNLF	VMPYNYPVLL	PLLDDLFKVH
KAKPTLKWRQ	SFESYLKTMP	PYYLGPLKKA	VRMMGAPNLI	ADSMEYGLSY
SVISYLKKLS	QQAKIESDRV	IGSVGKKVVQ	ETGIKVRSRS	HGLSMAYRKD
FQQLLQGISE	DVPHRLLDLN	MKEYTGFQVA	LLNKDLKPQT	FRNAYDIPRR
NLLDHLTRMR	SNLLKSTRRF	LKGQDEDQVH	SVPIAQMGNY	QEYLKQVPSP
LRELDPDQPR	RLHTFGNPFK	LDKKGMMIDE	ADEFVAGPQN	KHKRPGEPNM
QGIPKRRRCM	SPLLRGRQQN	PVVNNHIGGK	GPPAPTTQAQ	PDLIKPLPLH
KISETTNDSI	IHDVVENHVA	DQLSSDITPN	AMDTEFSASS	PASLLERPTN
HMEALGHDHL	GTNDLTVGGF	LENHEEPRDK	EQCAEENIPA	SSLNKGKKLM
HCRSHEEVNT	ELKAQIMKEI	RKPGRKYERI	FTLLKHVQGS	LQTRLIFLQN
VIKEASRFKK	RMLIEQLENF	LDEIHRRANQ	INHINSN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000102786 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035161 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.
↑ Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.
1 2 "Entrez Gene: INTS6 integrator complex subunit 6".
↑ "UniProt, Q9UL03". Pristupljeno 11. 9. 2017.

Dopunska literatura

Buchsbaum S, Morris C, Bochard V, Jalinot P (2007). "Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle". Oncogene. 26 (35): 5132–44. doi:10.1038/sj.onc.1210314. PMID 17310990.
Hernández M, Papadopoulos N, Almeida TA (2006). "Absence of mutations in DICE1/DDX26 gene in human cancer cell lines with frequent 13q14 deletions". Cancer Genet. Cytogenet. 163 (1): 91–2. doi:10.1016/j.cancergencyto.2005.04.014. PMID 16271964.
Röpke A, Buhtz P, Böhm M, et al. (2005). "Promoter CpG hypermethylation and downregulation of DICE1 expression in prostate cancer". Oncogene. 24 (44): 6667–75. doi:10.1038/sj.onc.1208824. PMID 16007164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wieland I, Sell C, Weidle UH, Wieacker P (2005). "Ectopic expression of DICE1 suppresses tumor cell growth". Oncol. Rep. 12 (2): 207–11. doi:10.3892/or.12.2.207. PMID 15254679.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li WJ, Hu N, Su H, et al. (2003). "Allelic loss on chromosome 13q14 and mutation in deleted in cancer 1 gene in esophageal squamous cell carcinoma". Oncogene. 22 (2): 314–8. doi:10.1038/sj.onc.1206098. PMID 12527901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wieland I, Röpke A, Stumm M, et al. (2002). "Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells". Oncol. Res. 12 (11–12): 491–500. PMID 11939413.
Camargo AA, Nunes DN, Samaia HB, et al. (2002). "Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12". Braz. J. Med. Biol. Res. 34 (10): 1237–45. doi:10.1590/s0100-879x2001001000002. PMID 11593297.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102786 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035161 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10467397-5] Wieland I, Arden KC, Michels D, Klein-Hitpass L, Bohm M, Viars CS, Weidle UH (Oct 1999). "Isolation of DICE1: a gene frequently affected by LOH and downregulated in lung carcinomas". Oncogene. 18 (32): 4530–7. doi:10.1038/sj.onc.1202806. PMID 10467397.

[pmid16239144-6] Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N, Shiekhattar R (Oct 2005). "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II". Cell. 123 (2): 265–76. doi:10.1016/j.cell.2005.08.019. PMID 16239144.

[entrez-7] 1 2 "Entrez Gene: INTS6 integrator complex subunit 6".

[UniProt-8] "UniProt, Q9UL03". Pristupljeno 11. 9. 2017.

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